WIKI4

ChemicalBook > CAS DataBase List > WIKI4

Product Name: WIKI4
CAS No.: 838818-26-1
Chemical Name: WIKI4
Synonyms: WIKI;WIKI4;CS-1491;CS-2099;WIKI4 USP/EP/BP;WIKI4, Wnt/ beta catenin inhibitor;PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4;2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso;2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione;2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
CBNumber: CB22731164
Molecular Formula: C29H23N5O3S
Formula Weight: 521.59
MOL File: 838818-26-1.mol

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WIKI4 Property

Boiling point:: 783.1±70.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
pka: 1.70±0.10(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0760
Product name: WIKI4
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2022/05/15

Cayman Chemical

Product number: 14057
Product name: WIKI4
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 14057
Product name: WIKI4
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 14057
Product name: WIKI4
Purity: ≥98%
Packaging: 25mg
Price: $388
Updated: 2024/03/01

Cayman Chemical

Product number: 14057
Product name: WIKI4
Purity: ≥98%
Packaging: 50mg
Price: $728
Updated: 2024/03/01

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WIKI4 Chemical Properties,Usage,Production

Description

Tankyrases (TNKS) cleave NAD⁺ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC₅₀s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway. WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

Uses

WIKI4 is a novel Tankyrase inhibitor. It leads to inhibition of Wnt/?-catenin signaling.

storage

-20°C

WIKI4 Preparation Products And Raw materials

Raw materials

Preparation Products

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WIKI4 Suppliers

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838818-26-1, WIKI4Related Search:

xav-939 Selumetinib TAK-733 Neratinib GSK-3BETA INHIBITOR XII Lapatinib Ditosylate

WIKI4

2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

WIKI

2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso

1H-?Benz[de]?isoquinoline-?1,?3(2H)?-?dione, 2-?[3-?[[4-?(4-?methoxyphenyl)?-?5-?(4-?pyridinyl)?-?4H-?1,?2,?4-?triazol-?3-?yl]?thio]?propyl]?-

CS-2099

CS-1491

2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

WIKI4 USP/EP/BP

PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4

WIKI4, Wnt/ beta catenin inhibitor

838818-26-1

Inhibitors