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WIKI4

Product Name
WIKI4
CAS No.
838818-26-1
Chemical Name
WIKI4
Synonyms
WIKI;WIKI4;CS-1491;CS-2099;WIKI4 USP/EP/BP;PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4;2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso;2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione;2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-?Benz[de]?isoquinoline-?1,?3(2H)?-?dione, 2-?[3-?[[4-?(4-?methoxyphenyl)?-?5-?(4-?pyridinyl)?-?4H-?1,?2,?4-?triazol-?3-?yl]?thio]?propyl]?-
CBNumber
CB22731164
Molecular Formula
C29H23N5O3S
Formula Weight
521.59
MOL File
838818-26-1.mol
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WIKI4 Property

Boiling point:
783.1±70.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble10mg/mL, clear (warmed)
pka
1.70±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0760
Product name
WIKI4
Purity
≥98% (HPLC)
Packaging
5mg
Price
$113
Updated
2022/05/15
Cayman Chemical
Product number
14057
Product name
WIKI4
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
14057
Product name
WIKI4
Purity
≥98%
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
14057
Product name
WIKI4
Purity
≥98%
Packaging
25mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
14057
Product name
WIKI4
Purity
≥98%
Packaging
50mg
Price
$728
Updated
2024/03/01
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WIKI4 Chemical Properties,Usage,Production

Description

Tankyrases (TNKS) cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway. WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

Uses

WIKI4 is a novel Tankyrase inhibitor. It leads to inhibition of Wnt/?-catenin signaling.

storage

-20°C

WIKI4 Preparation Products And Raw materials

Raw materials

Preparation Products

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WIKI4 Suppliers

China 61 India 2 United Kingdom 2 United States 12 Global 77

838818-26-1, WIKI4Related Search:

xav-939 Selumetinib TAK-733 Neratinib GSK-3BETA INHIBITOR XII Lapatinib Ditosylate

  • WIKI4
  • 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
  • WIKI
  • 2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso
  • 1H-?Benz[de]?isoquinoline-?1,?3(2H)?-?dione, 2-?[3-?[[4-?(4-?methoxyphenyl)?-?5-?(4-?pyridinyl)?-?4H-?1,?2,?4-?triazol-?3-?yl]?thio]?propyl]?-
  • CS-2099
  • CS-1491
  • 2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • WIKI4 USP/EP/BP
  • PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4
  • 838818-26-1
  • Inhibitors