(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
- Product Name
- (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
- CAS No.
- 1335316-40-9
- Chemical Name
- (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
- Synonyms
- PLV-09-40;Velpatasvir Impurity 6;Velpatasvir Intermediate 5;(2S,5S)-1-(2-Methoxycarbonylamino-;(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline;(5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline;(2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl);L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)-;(5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline;(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic
- CBNumber
- CB22750330
- Molecular Formula
- C13H22N2O5
- Formula Weight
- 286.32
- MOL File
- 1335316-40-9.mol
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Property
- Melting point:
- 134 - 136°C
- Boiling point:
- 489.9±40.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- refractive index
- 1.502
- Flash point:
- 250.1 ± 27.3 °C
- storage temp.
- -20°C, Inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.61±0.40(Predicted)
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C13H22N2O5/c1-7(2)10(14-13(19)20-4)11(16)15-8(3)5-6-9(15)12(17)18/h7-10H,5-6H2,1-4H3,(H,14,19)(H,17,18)/t8-,9-,10-/m0/s1
- InChIKey
- PNAXKGVRCAXIJK-GUBZILKMSA-N
- SMILES
- C(O)(=O)[C@@H]1CC[C@H](C)N1C(=O)[C@H](C(C)C)NC(OC)=O
N-Bromosuccinimide Price
- Product number
- M261343
- Product name
- (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CD22004812
- Product name
- (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CM101923
- Product name
- (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
- Purity
- 97%
- Packaging
- 5g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- CM101923
- Product name
- (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline
- Purity
- 97%
- Packaging
- 10g
- Price
- $370
- Updated
- 2021/12/16
- Product number
- CD22004812
- Product name
- (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production
Uses
(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline is an antiviral agent and Velpatasvir (V116000) intermediate. Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.
Synthesis
To an ice-cold stirred solution of ethyl (2S,5S)-1 -[(2S)-2- (methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidine-2- carboxylate (5.6 g, 17.8 mmol) in ethanol (18 ml) is added a solution of lithium hydroxide monohydrate (17.8 mL of 1.7 M, 30.3 mmol). The reaction mixture is stirred for 5 hours at rt. The reaction mixture is concentrated, diluted with water, washed with ether. The aqueous solution is acidified with aq. 1 N HCl, extracted with CH2CI2. The combined extracts are washed with brine, dried (Na2S04), concentrated to afford (2S,5S)-1 -[(2S)-2-(methoxycarbonylamino)-3- methyl-butanoyl]-5-methyl-pyrrolidine-2-carboxylic acid (5g, 94%) as a white solid.
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Suppliers
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View Lastest Price from (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid manufacturers
- Product
- (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-08
- Product
- (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline 1335316-40-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10