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Sulfamethazine sodium salt

Product Name
Sulfamethazine sodium salt
CAS No.
1981-58-4
Chemical Name
Sulfamethazine sodium salt
Synonyms
sulmet;vesadin;bovibol;Sulfoxine 33;sodiumsulfadimidine;sodiumsulfametazine;SULFADIMIDINE SODIUM;sulfamethazinesodium;sodiumsulfamethazine;sodiumsulfamezathine
CBNumber
CB2284761
Molecular Formula
C12H15N4NaO2S
Formula Weight
302.33
MOL File
1981-58-4.mol
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Sulfamethazine sodium salt Property

Melting point:
>288°C (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
form 
powder
color 
white to off-white
Water Solubility 
H2O: soluble 50mg/mL
Merck 
14,8915
Stability:
Hygroscopic
InChI
InChI=1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
InChIKey
WIVZAHIZHZEEOX-UHFFFAOYSA-N
SMILES
S(C1C=CC(N)=CC=1)(=O)(=O)NC1=NC(C)=CC(C)=N1.[NaH]
CAS DataBase Reference
1981-58-4
EPA Substance Registry System
Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt (1981-58-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
WO9300000
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5637
Product name
Sulfamethazine sodium salt
Purity
≥98%
Packaging
25g
Price
$51.3
Updated
2025/07/31
Sigma-Aldrich
Product number
S5637
Product name
Sulfamethazine sodium salt
Purity
≥98%
Packaging
100g
Price
$74.4
Updated
2025/07/31
TCI Chemical
Product number
S0583
Product name
Sulfamethazine Sodium Salt
Purity
>97.0%(HPLC)(N)
Packaging
25g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
S0583
Product name
Sulfamethazine Sodium Salt
Purity
>97.0%(HPLC)(N)
Packaging
500g
Price
$191
Updated
2025/07/31
TRC
Product number
S699080
Product name
Sulfamethazine Sodium Salt
Packaging
10g
Price
$70
Updated
2021/12/16
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Sulfamethazine sodium salt Chemical Properties,Usage,Production

Chemical Properties

White or milky white crystalline powder, odorless or almost odorless, easily soluble in water, slightly soluble in ethanol.

Uses

Antibacterial;Inhibitor of folic acid synthesis

Biological Activity

Sulfamethazine is an antimicrobial sulfur drug th at blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

in vivo

Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1].

Animal Model:19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1]
Dosage:80 mg/kg
Administration:Intravenous injection (Pharmacokinetic study)
Result:The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.

Sulfamethazine sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Sulfamethazine sodium salt Suppliers

Australia 1 Austria 1 Belgium 1 Brazil 1 Canada 2 China 265 Czech Republic 1 Europe 2 Germany 7 India 14 Japan 1 Mexico 1 Spain 1 Switzerland 2 The Netherlands 4 United Kingdom 4 United States 23 Global 331
HBCChem, Inc.
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View Lastest Price from Sulfamethazine sodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sulfamethazine sodium salt 1981-58-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-101%;BP
Supply Ability
1000KGS
Release date
2021-07-05
Sinoway Industrial co., ltd.
Product
Sulfadimidine Sodium 1981-58-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-07-15
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Sulfamethazine sodium salt 1981-58-4
Price
US $0.00/kg
Min. Order
25kg
Purity
＞99%
Supply Ability
10tons
Release date
2024-04-25

1981-58-4, Sulfamethazine sodium saltRelated Search:

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  • 1981-58-4
  • C12H14N4NaO2S
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  • C12H13N4O2SNa
  • Antibiotics
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  • Antibiotics A to Z
  • BioChemical
  • Animal medication
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  • sulfonamides
  • Pharmaceutical intermediate
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  • Biochemistry
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  • 1981-58-4