TYRPHOSTIN B7

Product Name: TYRPHOSTIN B7
CAS No.: 134036-53-6
Chemical Name: TYRPHOSTIN B7
Synonyms: AG 370;TYRPHOSTIN B7;TYRPHOSTIN AG 370;TYROPHOSTIN AG 370;2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE;2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-;2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
CBNumber: CB2288901
Molecular Formula: C15H9N5
Formula Weight: 259.27
MOL File: 134036-53-6.mol

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TYRPHOSTIN B7 Property

Boiling point:: 714.1±60.0 °C(Predicted)
Density: 1.396±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: soluble
form: Yellow solid.
pka: 15.95±0.30(Predicted)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010568
Product name: AG-370
Purity: ≥95% (cis/trans mixture)
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10010568
Product name: AG-370
Purity: ≥95% (cis/trans mixture)
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 10010568
Product name: AG-370
Purity: ≥95% (cis/trans mixture)
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 10010568
Product name: AG-370
Purity: ≥95% (cis/trans mixture)
Packaging: 25mg
Price: $957
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: KIN0000514
Product name: AG-370
Purity: 95.00%
Packaging: 1MG
Price: $460
Updated: 2021/12/16

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TYRPHOSTIN B7 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC₅₀ value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC₅₀ = 820 μM).

Definition

ChEBI: AG-370 is a member of indoles.

in vitro

previous study found that ag-370 inhibited pdgf receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the pdgf receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. when compared with ag18, a potent egf receptor blocker, ag370 was more efficient in inhibiting pdgf-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. under the conditions in which ag370 could inhibit pdgf-induced mitogenesis and phosphorylation, ag18 did not alter [125i]pdgf internalization and enhance [125i]pdgf binding. these findings suggested that ag370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by pdgf [1].

IC 50

20 μm for pdgf receptor kinase in human bone marrow fibroblasts

References

[1] bryckaert, m. c.,eldor, a.,fontenay, m., et al. inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. experimental cell research 199, 255-261 (1992).

TYRPHOSTIN B7 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B7 Suppliers

China 21 Switzerland 2 United Kingdom 3 United States 10 Global 36

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134036-53-6, TYRPHOSTIN B7Related Search:

TYRPHOSTIN A25,TYRPHOSTIN 25 TYRPHOSTIN 46,TYRPHOSTIN A46 TYRPHOSTIN A1,TYRPHOSTIN 1 TYRPHOSTIN A9,TYRPHOSTIN 9 TYRPHOSTIN A51,TYRPHOSTIN 51 3-PENTENENITRILE 2-AMINO-1-PROPENE-1,1,3-TRICARBONITRILE 3-Butenenitrile TYRPHOSTIN 957 TYRPHOSTIN A8,TYRPHOSTIN AG 10 AG 825 (Tyrphostin AG 825),Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide AG 213 (Tyrphostin AG 213),TYRPHOSTIN 47,TYRPHOSTIN A47 BIS-TYRPHOSTIN TYRPHOSTIN A23,TYRPHOSTIN 23,AG 18 (Tyrphostin A23) TYRPHOSTIN A63,TYRPHOSTIN 63 TYRPHOSTIN AG 1007 TYRPHOSTIN A47,TYRPHOSTIN 47 TYRPHOSTIN 51,TYRPHOSTIN A51

AG 370

2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7

TYROPHOSTIN AG 370

TYRPHOSTIN B7

TYRPHOSTIN AG 370

3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE

2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE

2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE

2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-

134036-53-6

Platelet Derived Growth Factor Receptor (PDGFR)

Receptor Tyrosine Kinase Inhibitors

Kinase/Phosphatase Biology

Cell Signaling and Neuroscience

Cell Biology

BioChemical