ChemicalBook > CAS DataBase List > 6-Aminofluorescein

6-Aminofluorescein

Product Name
6-Aminofluorescein
CAS No.
51649-83-3
Chemical Name
6-Aminofluorescein
Synonyms
6-AF;6-AFM;(isoMer II);6-AMINOFLUORESCEIN;6-AMinofluorescein 6-Aminofluorescein (6-AF);AMINOFLUORESCEIN ISOMER II;FLUORESCEINAMINE, ISOMER 2;FLUORESCEINMINE, ISOMER 2,;FLUORESCEINAMINE, ISOMER II
CBNumber
CB2300526
Molecular Formula
C20H13NO5
Formula Weight
347.32
MOL File
51649-83-3.mol
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6-Aminofluorescein Property

Melting point:
285 °C (dec.)(lit.)
Boiling point:
481.89°C (rough estimate)
Density 
1.3724 (rough estimate)
refractive index 
1.5180 (estimate)
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, clear, yellow to very dark yellow-orange
pka
9.34±0.20(Predicted)
form 
Solid
color 
Yellow to Orange
BRN 
51708
Stability:
Light and Moisture Sensitive
InChI
InChI=1S/C20H13NO5/c21-10-1-4-13-16(7-10)20(26-19(13)24)14-5-2-11(22)8-17(14)25-18-9-12(23)3-6-15(18)20/h1-9,22-23H,21H2
InChIKey
YOAWSYSKQHLFPM-UHFFFAOYSA-N
SMILES
C12(C3=C(C=C(O)C=C3)OC3=C1C=CC(O)=C3)C1=C(C=CC(N)=C1)C(=O)O2
CAS DataBase Reference
51649-83-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10-23
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
07985
Product name
6-Aminofluorescein
Purity
BioReagent, suitable for fluorescence, ~95% (HPLC)
Packaging
1g
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
07985
Product name
6-Aminofluorescein
Purity
BioReagent, suitable for fluorescence, ~95% (HPLC)
Packaging
5g
Price
$676
Updated
2024/03/01
TCI Chemical
Product number
A0864
Product name
6-Aminofluorescein (isomer II)
Purity
>95.0%(T)
Packaging
1g
Price
$183
Updated
2024/03/01
TCI Chemical
Product number
A0864
Product name
6-Aminofluorescein (isomer II)
Purity
>95.0%(T)
Packaging
5g
Price
$692
Updated
2024/03/01
Sigma-Aldrich
Product number
201634
Product name
6-Aminofluorescein
Packaging
250mg
Price
$198
Updated
2024/03/01
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6-Aminofluorescein Chemical Properties,Usage,Production

Description

6-Aminofluorescein (6-AF) is a new fluorescence dye with bright colors and high fluorescence intensity. Its chemical structure history contains a nitrogen group and a fluorescent group. The presence of the fluorescent component enables 6-Aminofluorescein to emit a distinct fluorescent signal when excited, making it valuable for fluorescent labeling and imaging. It is widely used in biological science research, chemical analysis and fluorescence microscopy.

Chemical Properties

Yellow Solid

Uses

Fluorescent labeling reagent for proteins. Glycosaminoglycuronans react with 6-aminofluorescein to yield fluorescent derivatives. Used in the fluorescent antibody technique for rapid identification of pathogens.

Biological Functions

6-Aminofluorescein has been demonstrated to be useful fluorescent labeling reagent for fullerene-based liposome nanostructures termed "buckysomes". 6-aminofluorescein dissolved in 0.1 N NaOH can be quantified from a maximum absorbance at 490 nm. Decarboxylated 6-aminofluorescein dissolved 6 N HCl (prepare by constant boiling at 110° C for 24 h) can be quantified from a maximum absorbance at 454 nm. Aldehyde groups are formed by oxidateive damage to proteins, which can be detected by conjugation to decarboxylated 6-aminofluorescein. 6-Aminofluorescein has been used to determine its ability to potentiate the antiviral activity of poly r (A-U).

References

[1] BHARATE G Y, QIN H, FANG J. Poly(Styrene-Co-Maleic Acid)-Conjugated 6-Aminofluorescein and Rhodamine Micelle as Macromolecular Fluorescent Probes for Micro-Tumors Detection and Imaging[J]. Journal of Personalized Medicine, 2022, 12. DOI:10.3390/jpm12101650.
[2] Müller, Werner EG, and Heinz Christoph Schr?der, eds. Biological Response Modifiers—Interferons, Double-Stranded RNA and 2′, 5′-Oligoadenylates. Vol. 14. Springer Science & Business Media, 2012.

6-Aminofluorescein Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Aminofluorescein Suppliers

Suzhouhongxiong
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18051745768 18051745768
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Suzhouhongxiong@163.com
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China
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Adamas Reagent, Ltd.
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View Lastest Price from 6-Aminofluorescein manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
6-Aminofluorescein 51649-83-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Hebei Weibang Biotechnology Co., Ltd
Product
6-Aminofluorescein 51649-83-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Hebei Mojin Biotechnology Co., Ltd
Product
6-Aminofluorescein 51649-83-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-29

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