3-Fluoro-4-methylaniline
- Product Name
- 3-Fluoro-4-methylaniline
- CAS No.
- 452-77-7
- Chemical Name
- 3-Fluoro-4-methylaniline
- Synonyms
- 3-FLUORO-P-TOLUIDINE;3-fluoro-p-toluidin;3-Fluoro-4-methylani;4-AMINO-2-FLUOROTOLUENE;3-FLUORO-PARA-TOLUIDINE;3-FLUORO-4-METHYLANILINE;2-FLUORO-4-AMINO-TOLUENE;3-Fluoro-4-methylaniline98%;3-Fluoro-4-methylaniline>3-fluoro-4-methyl-benzenamin
- CBNumber
- CB2301992
- Molecular Formula
- C7H8FN
- Formula Weight
- 125.14
- MOL File
- 452-77-7.mol
3-Fluoro-4-methylaniline Property
- Melting point:
- 30-32 °C (lit.)
- Boiling point:
- 93°C 12mm
- Density
- 1.093 g/mL at 25 °C (lit.)
- refractive index
- 1.5385-1.5405
- Flash point:
- 88 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to lump to clear liquid
- pka
- 4.02±0.10(Predicted)
- Specific Gravity
- 1.093
- color
- Light yellow to Brown
- BRN
- 2715987
- InChI
- InChI=1S/C7H8FN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3
- InChIKey
- MGRHBBRSAFPBIN-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(C)C(F)=C1
- CAS DataBase Reference
- 452-77-7(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 36/37/38-23/24/25-20/21/22
- Safety Statements
- 45-36/37/39-26-36/37-36
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- XU6825000
- Hazard Note
- Toxic/Irritant
- HazardClass
- 6.1(b)
- PackingGroup
- I
- HS Code
- 29214300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 222666
- Product name
- 3-Fluoro-4-methylaniline
- Purity
- 99%
- Packaging
- 5g
- Price
- $23.7
- Updated
- 2023/01/07
- Product number
- 222666
- Product name
- 3-Fluoro-4-methylaniline
- Purity
- 99%
- Packaging
- 25g
- Price
- $82.2
- Updated
- 2023/01/07
- Product number
- F0440
- Product name
- 3-Fluoro-4-methylaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- F0440
- Product name
- 3-Fluoro-4-methylaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- F600098
- Product name
- 3-Fluoro-4-methylaniline
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
3-Fluoro-4-methylaniline Chemical Properties,Usage,Production
Chemical Properties
clear pale yellow to brownish liquid after melting
Characteristics
3-Fluoro-4-methylaniline is an amide and has anti-cancer properties.
Uses
3-Fluoro-4-methylaniline is a synthesized compound that is used to produce anti-cancer agents.
Synthesis
1427-07-2
452-77-7
General procedure for the synthesis of 3-fluoro-4-methylaniline from 2-fluoro-4-nitrotoluene: Freshly distilled toluene (0.6 mL), aromatic nitro compounds (0.60 mmol), indium triiodide (InI3, 14.9 mg, 0.030 mmol) and 1,1,3,3-tetramethyldi siloxane (TMDS, 318 μL, 1.80 mmol). After sealing the vial with a polytetrafluoroethylene (PTFE) septum, the mixture was stirred at 60 °C (bath temperature) and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 5 mL of aqueous sodium bicarbonate (NaHCO3) was added to the mixture, which was then extracted with ethyl acetate (EtOAc, 3 × 6 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: n-hexane-ethyl acetate, from 9:1 to 4:1) to obtain the target product 3-fluoro-4-methylaniline.
References
[1] Tetrahedron Letters, 2003, vol. 44, # 42, p. 7783 - 7787
[2] Synthesis (Germany), 2015, vol. 47, # 20, p. 3179 - 3185
[3] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[4] Monatshefte fuer Chemie, 1959, vol. 90, p. 683,687
[5] Journal of the Chemical Society, 1949, p. Spl. 113
3-Fluoro-4-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Fluoro-4-methylaniline Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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- Country
- Americas
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- Advantage
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View Lastest Price from 3-Fluoro-4-methylaniline manufacturers
- Product
- 3-Fluoro-4-methylaniline 452-77-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-01
- Product
- 3-Fluoro-4-methylaniline 452-77-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-28
- Product
- 3-Fluoro-4-methylaniline 452-77-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24