ChemicalBook > CAS DataBase List > 3-Fluoro-4-methylaniline

3-Fluoro-4-methylaniline

Product Name: 3-Fluoro-4-methylaniline
CAS No.: 452-77-7
Chemical Name: 3-Fluoro-4-methylaniline
Synonyms: 3-FLUORO-P-TOLUIDINE;3-fluoro-p-toluidin;3-Fluoro-4-methylani;4-AMINO-2-FLUOROTOLUENE;3-FLUORO-PARA-TOLUIDINE;3-FLUORO-4-METHYLANILINE;2-FLUORO-4-AMINO-TOLUENE;3-Fluoro-4-methylaniline98%;3-Fluoro-4-methylaniline>3-fluoro-4-methyl-benzenamin
CBNumber: CB2301992
Molecular Formula: C7H8FN
Formula Weight: 125.14
MOL File: 452-77-7.mol

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3-Fluoro-4-methylaniline Property

Melting point:: 30-32 °C (lit.)
Boiling point:: 93°C 12mm
Density: 1.093 g/mL at 25 °C (lit.)
refractive index: 1.5385-1.5405
Flash point:: 88 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to lump to clear liquid
pka: 4.02±0.10(Predicted)
Specific Gravity: 1.093
color: Light yellow to Brown
BRN: 2715987
InChI: InChI=1S/C7H8FN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3
InChIKey: MGRHBBRSAFPBIN-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(C)C(F)=C1
CAS DataBase Reference: 452-77-7(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 36/37/38-23/24/25-20/21/22
Safety Statements: 45-36/37/39-26-36/37-36
RIDADR: 2811
WGK Germany: 3
RTECS: XU6825000
Hazard Note: Toxic/Irritant
HazardClass: 6.1(b)
PackingGroup: I
HS Code: 29214300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 222666
Product name: 3-Fluoro-4-methylaniline
Purity: 99%
Packaging: 5g
Price: $23.7
Updated: 2023/01/07

Sigma-Aldrich

Product number: 222666
Product name: 3-Fluoro-4-methylaniline
Purity: 99%
Packaging: 25g
Price: $82.2
Updated: 2023/01/07

TCI Chemical

Product number: F0440
Product name: 3-Fluoro-4-methylaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: F0440
Product name: 3-Fluoro-4-methylaniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $77
Updated: 2021/12/16

TRC

Product number: F600098
Product name: 3-Fluoro-4-methylaniline
Packaging: 5g
Price: $60
Updated: 2021/12/16

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3-Fluoro-4-methylaniline Chemical Properties,Usage,Production

Chemical Properties

clear pale yellow to brownish liquid after melting

Characteristics

3-Fluoro-4-methylaniline is an amide and has anti-cancer properties.

Uses

3-Fluoro-4-methylaniline is a synthesized compound that is used to produce anti-cancer agents.

Synthesis

1427-07-2

452-77-7

General procedure for the synthesis of 3-fluoro-4-methylaniline from 2-fluoro-4-nitrotoluene: Freshly distilled toluene (0.6 mL), aromatic nitro compounds (0.60 mmol), indium triiodide (InI3, 14.9 mg, 0.030 mmol) and 1,1,3,3-tetramethyldi siloxane (TMDS, 318 μL, 1.80 mmol). After sealing the vial with a polytetrafluoroethylene (PTFE) septum, the mixture was stirred at 60 °C (bath temperature) and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 5 mL of aqueous sodium bicarbonate (NaHCO3) was added to the mixture, which was then extracted with ethyl acetate (EtOAc, 3 × 6 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: n-hexane-ethyl acetate, from 9:1 to 4:1) to obtain the target product 3-fluoro-4-methylaniline.

References

[1] Tetrahedron Letters, 2003, vol. 44, # 42, p. 7783 - 7787
[2] Synthesis (Germany), 2015, vol. 47, # 20, p. 3179 - 3185
[3] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[4] Monatshefte fuer Chemie, 1959, vol. 90, p. 683,687
[5] Journal of the Chemical Society, 1949, p. Spl. 113

3-Fluoro-4-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Fluoro-4-methylaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Fluoro-4-methylaniline 452-77-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Fluoro-4-methylaniline 452-77-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-28

Career Henan Chemical Co

Product: 3-Fluoro-4-methylaniline 452-77-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

452-77-7, 3-Fluoro-4-methylanilineRelated Search:

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452-77-7

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