ChemicalBook > CAS DataBase List > Phenytoin sodium

Phenytoin sodium

Product Name
Phenytoin sodium
CAS No.
630-93-3
Chemical Name
Phenytoin sodium
Synonyms
DILANTIN;di-len;ditoin;epelin;epinat;eptoin;enkefal;tacosal;alepsin;dihydan
CBNumber
CB2304645
Molecular Formula
C15H13N2NaO2
Formula Weight
276.27
MOL File
630-93-3.mol
More
Less

Phenytoin sodium Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
aqueous base: soluble
form 
Crystalline Powder
color 
White to almost white
Merck 
14,7322
BCS Class
2
Stability:
Hygroscopic
InChIKey
FJPYVLNWWICYDW-UHFFFAOYSA-M
CAS DataBase Reference
630-93-3(CAS DataBase Reference)
EPA Substance Registry System
Diphenylhydantoin sodium (630-93-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-43-62-63
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
MU1400000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29332100
Toxicity
LD50 orally in mice: 490 mg/kg (Fink, Swinyard)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4505
Product name
5,5-Diphenylhydantoin sodium salt
Purity
≥99%
Packaging
25g
Price
$63.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1535507
Product name
Phenytoin sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
D1331
Product name
5,5-Diphenylhydantoin Sodium Salt
Purity
>98.0%(T)
Packaging
25g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D1331
Product name
5,5-Diphenylhydantoin Sodium Salt
Purity
>98.0%(T)
Packaging
500g
Price
$271
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1492
Product name
Phenytoin sodium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$105
Updated
2024/03/01
More
Less

Phenytoin sodium Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder, slightly hygroscopic.

Uses

antibacterial

Uses

Antiepileptic

Uses

5,5-Diphenylhydantoin sodium salt has been used:

  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

brand name

Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].

General Description

Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.

Clinical Use

Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.

Safety Profile

Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.

Carcinogenicity

Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.

Solubility in water

1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.

Phenytoin sodium Preparation Products And Raw materials

Raw materials

Benzil

Preparation Products

More
Less

Phenytoin sodium Suppliers

Americas 1 Belgium 2 Brazil 2 Canada 4 China 252 Cyprus 1 Czech Republic 1 Europe 3 France 2 Germany 6 India 97 Indonesia 1 Italy 4 Japan 2 Malaysia 1 Mexico 1 Nigeria 1 South Korea 1 Switzerland 1 The Netherlands 3 United Arab Emirates 1 United Kingdom 10 United States 47 Venezuela 1 Global 445
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Alfa Chem
Tel
--
Fax
--
Email
alfachem@gmail.com
Country
United States
ProdList
226
Advantage
58
ZETA Pharmaceuticals, L.L.C.
Tel
--
Fax
--
Email
zeta@zetapharm.com
Country
United States
ProdList
102
Advantage
58
BADRIVISHAL CHEMICALS & PHARMACEUTICALS
Tel
--
Fax
--
Email
info@badrivishal.com
Country
United States
ProdList
12
Advantage
38
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Generichem Corporation
Tel
--
Fax
--
Email
info@generichem.com
Country
United States
ProdList
80
Advantage
60
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
J.P.Pharma-Chem Industries
Tel
--
Fax
--
Email
jpi@vsnl.com
Country
United States
ProdList
40
Advantage
52
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Aakash Chemicals and Dye-Stuffs, Inc.
Tel
--
Fax
--
Email
info@aakashchemicals.com
Country
United States
ProdList
1012
Advantage
54
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
More
Less

View Lastest Price from Phenytoin sodium manufacturers

Sinoway Industrial co., ltd.
Product
Phenytoin sodium 630-93-3
Price
US $0.00/kg
Min. Order
2kg
Purity
99%
Supply Ability
20tons
Release date
2024-03-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Phenytoin sodium 630-93-3
Price
US $1.00/Kg/Bag
Min. Order
1KG
Purity
98.0%~102.0%,USP40
Supply Ability
5ton/month
Release date
2021-06-05
Hangzhou Hyper Chemicals Limited
Product
Phenytoin sodium 630-93-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
USP, BP, EP
Supply Ability
5,000KG
Release date
2024-06-28

630-93-3, Phenytoin sodiumRelated Search:

Sodium citrate Sodium hydroxide Sodium acetate Diphenylmethane Sodium chloride Sodium bicarbonate DIPHENYLCYCLOPROPENONE Chlorodiphenylphosphine Sodium benzoate Diphenylphosphine Imidazolidinyl urea Trisodium phosphate Sodium alginate tert-Butylchlorodiphenylsilane Biphenyl Diclofenac sodium 5,5-Diphenylhydantoin 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

  • solantoin
  • solantyl
  • 5,5-DIPHENYLHYDANTOIN SODIUM
  • 5,5-DIPHENYLHYDANTOIN SODIUM SALT
  • 4-imidazolidinedione,5,5-diphenyl-monosodiumsalt
  • 5,5-diphenyl-hydantoimonosodiumsalt
  • 5,5-diphenylhydantoinsodiumsigmaultra
  • dilantinsodium
  • di-len
  • diphenin
  • diphenine
  • dipheninesodium
  • diphentoin
  • diphenylansodium
  • diphenylhydantoinsodium
  • ditoin
  • enkefal
  • epanutin
  • epelin
  • epilan-d
  • epinat
  • eptoin
  • fenitoinsodium
  • hidantalsodium
  • hydantin
  • hydantoinal
  • lepitoinsodium
  • novodiphenyl
  • sodium 5,5-diphenyl-2,4-imidazolidinedione
  • SODIUM 5,5-DIPHENYLHYDANTOIN
  • SODIUM DIPHENYLHYDANTOIN
  • PHENYTOIN SODIUM
  • PHENYTOIN SODIUM SALT
  • PHENYLTOIN SODIUM
  • DIPHENYLHYDANTOIN SODIUM SALT
  • DILANTIN
  • PHENYTOIN SODIUM (5,5-DIPHENYLIMIDAZOLIDINE-2,4-DIONE SODIUM)
  • 5,5-Diphenylhydantoin sodium salt, 98%, a potent multi-channel blocker
  • 5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE, 5,5-DIPHENYLHYDANTOIN SODIUM SALT
  • 5,5-Diphenylhydantoin sodium salt Solution, 100ppm
  • 2,4-Imidazolidinedione, 5,5-diphenyl-, sodium salt (1:1)
  • solublephenytoin
  • tacosal
  • 5,5-Diphenylhydatoin sodium salt
  • PHENYTOINUM NATRICUM
  • 2,4-Imidazolidinedione, 5,5-diphenyl-, monosodium salt
  • PHENYTOINSODIUM,USP
  • DIPHENYLHYDANTOINESODIUM
  • 5,5-Diphenyl-2,4
  • 5,5-DIPHENYLHYDANTOIN SODIUM SALT 98+%
  • 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
  • 5,5-diphenyl-2,4-imidazolidinedione monosodium salt
  • 5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE SODIUM SALT
  • 5,5-diphenyl-hydantoisodiumsalt
  • alepsin
  • aleviatinsodium
  • auranile
  • denylsodium