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RO2959 Hydrochloride

Product Name
RO2959 Hydrochloride
CAS No.
1219927-22-6
Chemical Name
RO2959 Hydrochloride
Synonyms
SYN5226;RO2959 HCl;RO2959 Hydrochloride;IP3,SOCE,Ca2+ release-activated Ca2+ channels,RO2959 Hydrochloride,Interleukin Related,inhibit,IL-2,Stim1,RO-2959 Hydrochloride,CRAC Channel,anti-proliferation,RO 2959,Calcium release-activated channels,T-cell,RO-2959,Orai1,heart,RO2959,Inhibitor,failure
CBNumber
CB23067576
Molecular Formula
C21H20ClF2N5OS
Formula Weight
463.93
MOL File
1219927-22-6.mol
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RO2959 Hydrochloride Property

storage temp. 
Store at -20°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0063986
Product name
RO2959hydrochloride
Packaging
5mg
Price
$350
Updated
2021/12/16
AK Scientific
Product number
SYN5226
Product name
RO2959Hydrochloride
Packaging
100mg
Price
$2635.25
Updated
2021/12/16
DC Chemicals
Product number
DC33579
Product name
RO2959Hydrochloride
Packaging
100mg
Price
$750
Updated
2021/12/16
DC Chemicals
Product number
DC33579
Product name
RO2959Hydrochloride
Packaging
1g
Price
$2600
Updated
2021/12/16
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RO2959 Hydrochloride Chemical Properties,Usage,Production

Biological Activity

RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with IC50 of 402 nM. It is a potent blocker of Orai1/Stim1 channel-mediated calcium storage entry (SOCE) with IC50 of 25 nM. It is also a potent inhibitor of human IL-2 production, effectively blocking T cell receptor-triggered gene expression and T cell functional pathways.

in vitro

RO2959 hydrochloride inhibits Orai1 and Orai3 with IC 50 values of 25 nM and 530 nM, respectively. It blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC < sub> 50 value of 265 nM.
It is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4 + T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction ).

target

CRAC channel

402 nM (IC 50 )

Orai1/Stim1 channels

25 nM (IC 50 )

IL-2

RO2959 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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RO2959 Hydrochloride Suppliers

China 28 United Kingdom 1 United States 4 Global 33
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

1219927-22-6, RO2959 HydrochlorideRelated Search:

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  • RO2959 Hydrochloride
  • RO2959 HCl
  • IP3,SOCE,Ca2+ release-activated Ca2+ channels,RO2959 Hydrochloride,Interleukin Related,inhibit,IL-2,Stim1,RO-2959 Hydrochloride,CRAC Channel,anti-proliferation,RO 2959,Calcium release-activated channels,T-cell,RO-2959,Orai1,heart,RO2959,Inhibitor,failure
  • SYN5226
  • 1219927-22-6