Description Natural occurrences Mechanism of action
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Verbascoside

Description Natural occurrences Mechanism of action
Product Name
Verbascoside
CAS No.
61276-17-3
Chemical Name
Verbascoside
Synonyms
ACTEOSIDE;ISOVERBASCOSIDE;Acetoside;KUSAGININ;Kusagi;TJC 160;NSC 603831;Russetinol;Verbacoside;VERBASCOSIDE
CBNumber
CB2306760
Molecular Formula
C29H36O15
Formula Weight
624.59
MOL File
61276-17-3.mol
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Verbascoside Property

Melting point:
232℃
Boiling point:
908.8±65.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Ethyl Acetate (Very Slightly), Methanol (Slightly)
pka
9.31±0.10(Predicted)
form 
Solid
color 
White to Pale Yellow
Stability:
Hygroscopic
InChIKey
FBSKJMQYURKNSU-ZLSOWSIRSA-N
LogP
0.077 (est)
CAS DataBase Reference
61276-17-3(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
2
RTECS 
LZ5786000
HS Code 
29389090
Toxicity
LD50 oral in rat: > 5gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1711455
Product name
Verbascoside
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$539
Updated
2024/03/01
Sigma-Aldrich
Product number
00820580
Product name
Verbascoside
Purity
primary pharmaceutical reference standard
Packaging
10mg
Price
$570
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL89289
Product name
Verbascoside
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$435
Updated
2023/01/07
TCI Chemical
Product number
V0153
Product name
Verbascoside
Purity
>97.0%(HPLC)
Packaging
10mg
Price
$141
Updated
2024/03/01
TCI Chemical
Product number
V0153
Product name
Verbascoside
Purity
>97.0%(HPLC)
Packaging
50mg
Price
$494
Updated
2024/03/01
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Verbascoside Chemical Properties,Usage,Production

Description

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Natural occurrences

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

Mechanism of action

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Chemical Properties

White solid

Uses

Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent.

Definition

ChEBI: Acteoside is a glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. It is a cinnamate ester, a disaccharide derivative, a member of catechols, a polyphenol and a glycoside. It is functionally related to a hydroxytyrosol and a trans-caffeic acid.

Enzyme inhibitor

This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.

Verbascoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Verbascoside Suppliers

China 260 France 2 Germany 5 India 3 Japan 1 United Kingdom 7 United States 29 USA 1 Global 308
TransMIT GmbH PlantMetaChem
Tel
+49-172-1024293
Fax
+49-(0)6422-938149
Email
pmc@transmit.de
Country
Germany
ProdList
142
Advantage
60
AppliChem GmbH
Tel
--
Fax
--
Email
service@applichem.de
Country
Germany
ProdList
968
Advantage
65
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
AppliChem GmbH
Tel
--
Fax
--
Email
service@applichem.de
Country
Germany
ProdList
1607
Advantage
74
cfm Oskar Tropitzsch
Tel
--
Fax
--
Country
Germany
ProdList
1136
Advantage
62
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View Lastest Price from Verbascoside manufacturers

Sinoway Industrial co., ltd.
Product
Desertliving Cistanche Extract 61276-17-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
Echinacoside 80%
Supply Ability
20 tons
Release date
2021-07-28
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
3,4-Dihydroxyphenethyl alcohol acteoside 61276-17-3
Price
US $31.88/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-27
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
VERBASCOSIDE WITH HPLC 61276-17-3
Price
US $31.87/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-27

61276-17-3, VerbascosideRelated Search:

Nicergoline CHLOROPHOSPHONAZO III Alkyl polyglucoside Cabergoline 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL STEVIA Dihydroergotoxine mesylate CALYCOSIN CALYCOSIN 7-O-GLUCOSIDE 6-O-ACETYLACTEOSIDE Forsythoside B CISTANOSIDE C ECHINACOSIDE ergotamine Angoroside C Isoacteoside CAMPNEOSIDE I MARTYNOSIDE

  • glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos
  • ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,
  • Acetoside
  • Extract from Verbena minutiflora (B864379)
  • [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • VERBASCOSIDE WITH HPLC
  • 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate]
  • 3,4-Dihydroxyphenethyl alcohol acteoside
  • Verbacoside
  • Acteoside(Verbascoside)
  • Distinctive PhytosteM Lilac
  • Verbascoside ,98%
  • NSC 603831
  • Russetinol
  • StereosperMin
  • TJC 160
  • Verbascoside(Acteoside)
  • Verbascoside, froM Cistanche deserticola Y.C.Ma
  • VERBASCOSIDE
  • ISOVERBASCOSIDE
  • KUSAGININ
  • B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-
  • 4-(3-(3,4-dihydroxyphenyl)-2-propenoate),(e)-beta-d-yl)
  • Verbascoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • ACTEOSIDE
  • β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
  • Nano Liposomal Acteoside
  • Verbascoside, 98%, from Cistanche deserticola Y.C.Ma
  • Acteoside Kusaginin 61276-17-3
  • Kusagi
  • Acteoside Standard
  • 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-Deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside
  • Verbascoside USP/EP/BP
  • Cistanche Deserticola Extract Acteoside
  • (2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
  • Verbascoside (15 mg)
  • 61276-17-3
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • Miscellaneous Natural Products