Verbascoside
Description Natural occurrences Mechanism of action- Product Name
- Verbascoside
- CAS No.
- 61276-17-3
- Chemical Name
- Verbascoside
- Synonyms
- ACTEOSIDE;ISOVERBASCOSIDE;Acetoside;KUSAGININ;Kusagi;TJC 160;NSC 603831;Russetinol;Verbacoside;VERBASCOSIDE
- CBNumber
- CB2306760
- Molecular Formula
- C29H36O15
- Formula Weight
- 624.59
- MOL File
- 61276-17-3.mol
Verbascoside Property
- Melting point:
- 232℃
- Boiling point:
- 908.8±65.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethyl Acetate (Very Slightly), Methanol (Slightly)
- pka
- 9.31±0.10(Predicted)
- form
- Solid
- color
- White to Pale Yellow
- Stability:
- Hygroscopic
- InChIKey
- FBSKJMQYURKNSU-ZLSOWSIRSA-N
- LogP
- 0.077 (est)
- CAS DataBase Reference
- 61276-17-3(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 2
- RTECS
- LZ5786000
- HS Code
- 29389090
- Toxicity
- LD50 oral in rat: > 5gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1711455
- Product name
- Verbascoside
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $539
- Updated
- 2024/03/01
- Product number
- 00820580
- Product name
- Verbascoside
- Purity
- primary pharmaceutical reference standard
- Packaging
- 10mg
- Price
- $570
- Updated
- 2024/03/01
- Product number
- PHL89289
- Product name
- Verbascoside
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $435
- Updated
- 2023/01/07
- Product number
- V0153
- Product name
- Verbascoside
- Purity
- >97.0%(HPLC)
- Packaging
- 10mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- V0153
- Product name
- Verbascoside
- Purity
- >97.0%(HPLC)
- Packaging
- 50mg
- Price
- $494
- Updated
- 2024/03/01
Verbascoside Chemical Properties,Usage,Production
Description
Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.
Natural occurrences
Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.
Mechanism of action
It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.
Chemical Properties
White solid
Uses
Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent.
Definition
ChEBI: Acteoside is a glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. It is a cinnamate ester, a disaccharide derivative, a member of catechols, a polyphenol and a glycoside. It is functionally related to a hydroxytyrosol and a trans-caffeic acid.
Enzyme inhibitor
This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
Verbascoside Preparation Products And Raw materials
Raw materials
Preparation Products
Verbascoside Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Verbascoside manufacturers
- Product
- Desertliving Cistanche Extract 61276-17-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- Echinacoside 80%
- Supply Ability
- 20 tons
- Release date
- 2021-07-28
- Product
- 3,4-Dihydroxyphenethyl alcohol acteoside 61276-17-3
- Price
- US $31.88/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-27
- Product
- VERBASCOSIDE WITH HPLC 61276-17-3
- Price
- US $31.87/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-27