LEVOCABASTINE

Product Name: LEVOCABASTINE
CAS No.: 79516-68-0
Chemical Name: LEVOCABASTINE
Synonyms: Bilina;ALKN006000;Levocabastin;LEVOCABASTINE;Levocabastina;Levocabastinum;Unii-H68bp06S81;Levocabastinum [latin];Levocabastina [spanish];Levocabastine [inn:ban]
CBNumber: CB2307787
Molecular Formula: C26H29FN2O2
Formula Weight: 420.52
MOL File: 79516-68-0.mol

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LEVOCABASTINE Property

Boiling point:: 589.9±50.0 °C(Predicted)
Density: 1.23
pka: 3.57±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006774
Product name: LEVOCABASTINE
Purity: 95.00%
Packaging: 5MG
Price: $498.26
Updated: 2021/12/16

AHH

Product number: MT-53192
Product name: Levocabastine
Purity: 98%
Packaging: 0.5g
Price: $910
Updated: 2021/12/16

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LEVOCABASTINE Chemical Properties,Usage,Production

Originator

Livostin,Janssen-Cilag,Belgium

Uses

Anti histaminic.

Definition

ChEBI: Levocabastine is a member of piperidines.

Manufacturing Process

4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)

brand name

Livostin (Novartis).

Therapeutic Function

Antihistaminic

LEVOCABASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

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LEVOCABASTINE Suppliers

China 8 Europe 2 India 1 United Kingdom 4 United States 11 Global 26

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7819
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 7724
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569262 +86-15003564040
Fax: 029-88380327
Email: 1087@dideu.com
Country: China
ProdList: 3167
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Hu Bei Jiutian Bio-medical Technology CO.,Ltd

Tel: 027-88013699 17354350817
Email: Ryan@jiutian-bio.com
Country: China
ProdList: 6001
Advantage: 58

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

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View Lastest Price from LEVOCABASTINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Levocabastine 79516-68-0
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-08

79516-68-0, LEVOCABASTINERelated Search:

Antazoline Pirenoxine 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 1-(4-FLUOROPHENYL)CYCLOHEXANECARBONITRILE 1-Phenyl-1-cyclohexanecarbonitrile 4-Fluorophenylacetonitrile 4-Phenylcyclohexanamine LEVOCABASTINE LEVOCABASTINE IMPURITY D 4-Piperidinecarboxylicacid,1-(1-methylethyl)-(9CI) 4-Piperidinemethanol,1-(1-methylethyl)-(9CI) (αS)-α-Isopropylbenzeneacetic acid PETHIDINIC ACID 5-Piperidinovaleronitrile Cabastine 4-phenyl-1-(4-phenylbutyl)piperidine

Levocabastine & Levocabastine Hydrochloride

(3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid

(3S,4R)-1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-Methyl-4-phenylpiperidine-4-carboxylic acid

LEVOCABASTINE

(3S,4R)-3-methyl-4-phenyl-1-[(1s,4s)-4-cyano-4-(4-fluorophenyl)cyclohexyl]piperidine-4-carboxylic acid

4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, [3S-[1(cis),3a,4b]]-

4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, (3S,4R)- (9CI)

(3S)-1-[4α-Cyano-4-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4-phenylpiperidine-4α-carboxylic acid

(3S)-1-[4α-Cyano-4β-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4β-phenyl-4α-piperidinecarboxylic acid

4-Piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3alpha,4beta))-

79547-78-7 (Hydrochloride)

Levocabastina

Levocabastina [spanish]

Levocabastine [inn:ban]

Levocabastinum

Levocabastinum [latin]

Unii-H68bp06S81

Levocabastin

4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, (3S,4R)-

LEVOCABASTINE USP/EP/BP

Bilina

ALKN006000

79516-68-0

C26H29FN2O2