LEVOCABASTINE
- Product Name
- LEVOCABASTINE
- CAS No.
- 79516-68-0
- Chemical Name
- LEVOCABASTINE
- Synonyms
- Bilina;ALKN006000;Levocabastin;LEVOCABASTINE;Levocabastina;Levocabastinum;Unii-H68bp06S81;Levocabastinum [latin];Levocabastina [spanish];Levocabastine [inn:ban]
- CBNumber
- CB2307787
- Molecular Formula
- C26H29FN2O2
- Formula Weight
- 420.52
- MOL File
- 79516-68-0.mol
LEVOCABASTINE Property
- Boiling point:
- 589.9±50.0 °C(Predicted)
- Density
- 1.23
- pka
- 3.57±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- API0006774
- Product name
- LEVOCABASTINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.26
- Updated
- 2021/12/16
- Product number
- MT-53192
- Product name
- Levocabastine
- Purity
- 98%
- Packaging
- 0.5g
- Price
- $910
- Updated
- 2021/12/16
LEVOCABASTINE Chemical Properties,Usage,Production
Originator
Livostin,Janssen-Cilag,Belgium
Uses
Anti histaminic.
Definition
ChEBI: Levocabastine is a member of piperidines.
Manufacturing Process
4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)
brand name
Livostin (Novartis).
Therapeutic Function
Antihistaminic
LEVOCABASTINE Preparation Products And Raw materials
Raw materials
Preparation Products
LEVOCABASTINE Suppliers
View Lastest Price from LEVOCABASTINE manufacturers
- Product
- Levocabastine 79516-68-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- LEVOCABASTINE 79516-68-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-17