ChemicalBook > CAS DataBase List > 4,5-Dimethyl-1,3-dioxol-2-one

4,5-Dimethyl-1,3-dioxol-2-one

Product Name
4,5-Dimethyl-1,3-dioxol-2-one
CAS No.
37830-90-3
Chemical Name
4,5-Dimethyl-1,3-dioxol-2-one
Synonyms
DMDO;4,5-Dimethyl-1,3-dioxolen-2-one;DIMETHYLDIOXOLONE;AZATMint-A;3-dioxol-2-one;ORDIMETHYLDIOXOLONE;4,5-Dimethyl-1,3-dio;Olmesartan Impurity 54;Dimethylvinylene carbonate;5-Dimethyl-1,3-dioxol-2-one
CBNumber
CB2310781
Molecular Formula
C5H6O3
Formula Weight
114.1
MOL File
37830-90-3.mol
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4,5-Dimethyl-1,3-dioxol-2-one Property

Melting point:
78°C
Boiling point:
130 °C / 6mmHg
Density 
1.181±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol
form 
Solid
color 
White
InChIKey
QYIOFABFKUOIBV-UHFFFAOYSA-N
CAS DataBase Reference
37830-90-3(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Dioxol-2-one,4,5-dimethyl-(37830-90-3)
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Safety

Risk Statements 
36/37/38-37-36
Safety Statements 
26-36/37/39-36
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
TMT00459
Product name
4,5-Dimethyl-1,3-dioxol-2-one
Packaging
1G
Price
$512
Updated
2023/06/20
TCI Chemical
Product number
D1920
Product name
4,5-Dimethyl-1,3-dioxol-2-one
Purity
>99.0%(GC)
Packaging
25g
Price
$49
Updated
2024/03/01
TRC
Product number
D472660
Product name
4,5-Dimethyl-1,3-dioxol-2-one
Packaging
100g
Price
$395
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK373976
Product name
4,5-Dimethyl-1,3-dioxol-2-one
Purity
99%
Packaging
1g
Price
$16
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD38408
Product name
4,5-Dimethyl-1,3-dioxol-2-one
Packaging
25g
Price
$40
Updated
2021/12/16
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4,5-Dimethyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

4,5-Dimethyl-1,3-dioxol-2-one is a dioxolanone derivative used in the preparation of synthetic chemotherapeutic antibiotics such as Prulifloxacin (P838885).

Application

4,5-Dimethyl-1,3-dioxol-2-one is a kind of important medicine intermediate, is mainly used in the modification of many medicines, to synthesize, has optically active chiral drug, thereby improves largely drug effect, reduces drug side effect.

Synthesis

1. distillation column is being housed, air set pipe, mechanical stirrer, add 3-hydroxy-2-butanone 88g, methylcarbonate 90g, tirethylene glycol dme 264g and sodium propylate 0.88g in the three-necked flask of thermometer, at 60-65 ℃ of reacting by heating mixture, carry out transesterification reaction 6h, the methyl alcohol of generation is removed in synchronous distillation, obtains carbonic acid monomethyl 3-hydroxy-2-butanone base ester.
2. improve reaction mixture temperature to 110-115 ℃, keep this thermotonus 5h, continue to steam the by products such as methyl alcohol.
3., after reaction finishes, reaction mixture is to room temperature, add concentrated hydrochloric acid with the neutralization reaction catalyzer to reaction mixture pH value in 7 left and right. After methylcarbonate is reclaimed in fractionation, the underpressure distillation aliphatic ether is appropriate.The distillation residuum is cooled to 0-5 ℃, and crystallization, filtration, obtain product 4,5-dimethyl-1,3-dioxole-2-ketone crude product 62.34g.
4. add recrystallization solvent and 0.62g gac in crude product, be heated to 80 ℃ of return stirring 0.5-1h, filtered while hot, filtrate 60 ℃ of lower evaporation concentration to after having mass crystallization to separate out, adopt cooling bath cooling concentration liquid to 0-5 ℃, the gained solids is dried 2h at 50 ℃ of lower normal pressures.
Can obtain highly purified 4,5-Dimethyl-1,3-dioxol-2-one white crystal, these are highly purified 4 years old, 5-dimethyl-1, the quality of 3-dioxole-2-ketone is 53.88g, yield is 47.26% (calculating with the 3-hydroxy-2-butanone), purity (high performance liquid chromatography) is 99.0%, and fusing point is 77-78 ℃.

4,5-Dimethyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dimethyl-1,3-dioxol-2-one Suppliers

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View Lastest Price from 4,5-Dimethyl-1,3-dioxol-2-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99.5%min GC
Supply Ability
10000kg
Release date
2021-11-19
Hebei Dangtong Import and export Co LTD
Product
4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3
Price
US $37600.00-37500.00/tons
Min. Order
1tons
Purity
99%
Supply Ability
1000tons
Release date
2023-02-22
.GZ HONESTCHEM CO.,LTD
Product
4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
500KG
Release date
2021-07-02

37830-90-3, 4,5-Dimethyl-1,3-dioxol-2-oneRelated Search:

Acetone oxime Dimethyl sulfide Dimethyl phthalate Dimethyl fumarate Dimethyl ether Selenium dioxide 1,4-Dioxane Methyl cyclopentenolone Dimethyl sulfoxide N,N-Dimethylformamide DIMETHYLGLYOXIME DISODIUM SALT 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ETHANE Olmesartan 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

  • 4,5-DIMETHYL-1,3-DIOXOL-2-ONE
  • 1,3-DIOXOL-2-ONE, 4,5-DIMETHYL-
  • DIMETHYLDIOXOLONE
  • 4,5-DIMETHYL-1,3-DIOXOLENE-2-ONE (DMDO)
  • 5-Dimethyl-1,3-dioxol-2-one
  • 4,5-Dimethyl-1,3-dioxolen-3-one
  • 4,5-Dimethyl-1,3-dioxolen-2-one
  • 4,5-dimethyl-2-oxo-1,3-dioxolene
  • DMDO
  • DMDO (4,5-DIMETHYL-1,3-DIOXOL-2-ONE)
  • 4,5-DIMETHYL-1,3-DIOXAL-2-ONE
  • 4,5-DIMETHYL-1,3-DIOXOL-2-ONE (DMDO)
  • 4,5-DIMETHYL-1,3-DIOXOL-2-ONE(OR DIMETHYLDIOXOLONE)
  • 4,5-DIMETHYL-1,3-DIOXOL-2-ONE 99+%
  • 4,5-Dimethyl-1,3-dioxocyclopenten-2-one
  • 4,5-DIMETHYL-1,3-DIOXO-2-ONE
  • 4,5-Dimethyl-1,3-dioxolen-2-one(DDO)
  • Carbonic acid 1,2-dimethylvinylene ester
  • Carbonic acid 2-butene-2,3-diyl ester
  • Dimethyl vinylene carbonate
  • Dimethylvinylene carbonate
  • 4,5-dimethyl-1,3-dioxa-4-cyclopentene-2-one
  • 4,5-Dimethyl-1,3-dio
  • 4,5-Dimethyl-1,3-dioxol-2-one dimethyldioxolone ethyldiox
  • 3-dioxol-2-one
  • diMethyl-2H-1,3-dioxol-2-one
  • 4-5-Methyl-l,3-dioxocyclopenten-2–one
  • 4,5-Dimethyl-1,3-dioxolen-3-one(DMDO)
  • 4,5-dimethyl 1,3-2 oxygen heterocycle pentene-2-ketone
  • Olmesartan Impurity 54
  • AZATMint-A
  • Olmesartan Medoxomil Impurity 37
  • Olmesartan DMDO-CL Impurity Ⅱ
  • ORDIMETHYLDIOXOLONE
  • 4,5-Dimethyl-1,3-dioxol-2-one&gt
  • Olmesartan DMDO-Cl Impurity Ⅴ
  • Olmesartan Dimethyl Impurity
  • 4,5-Dimethyl-1,3-dioxol-2-one USP/EP/BP
  • 4,5-dimethyl-l,3-dioxolene-2-one (DMDO)
  • 4,5-Dimethyl-1,3-dioxole-2-one(DMDO)
  • 4.5 Dimethyl 1.3 dioxane 2-one
  • 4,5-Dimethy-1,3-dioxol-2-one(DMDO)
  • 37830-90-3
  • Pharmaceutical Intermediates
  • Agricultural chemicals(bactericide)
  • Oxygen cyclic compounds
  • Fluorobenzene