4,5-Dimethyl-1,3-dioxol-2-one

Product Name: 4,5-Dimethyl-1,3-dioxol-2-one
CAS No.: 37830-90-3
Chemical Name: 4,5-Dimethyl-1,3-dioxol-2-one
Synonyms: DMDO;4,5-Dimethyl-1,3-dioxolen-2-one;DIMETHYLDIOXOLONE;AZATMint-A;3-dioxol-2-one;ORDIMETHYLDIOXOLONE;4,5-Dimethyl-1,3-dio;Olmesartan Impurity 54;Dimethylvinylene carbonate;5-Dimethyl-1,3-dioxol-2-one
CBNumber: CB2310781
Molecular Formula: C5H6O3
Formula Weight: 114.1
MOL File: 37830-90-3.mol

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4,5-Dimethyl-1,3-dioxol-2-one Property

Melting point:: 78°C
Boiling point:: 130 °C / 6mmHg
Density: 1.181±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Solid
color: White
InChIKey: QYIOFABFKUOIBV-UHFFFAOYSA-N
CAS DataBase Reference: 37830-90-3(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Dioxol-2-one,4,5-dimethyl-(37830-90-3)

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Safety

Risk Statements: 36/37/38-37-36
Safety Statements: 26-36/37/39-36
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: TMT00459
Product name: 4,5-Dimethyl-1,3-dioxol-2-one
Packaging: 1G
Price: $512
Updated: 2023/06/20

TCI Chemical

Product number: D1920
Product name: 4,5-Dimethyl-1,3-dioxol-2-one
Purity: >99.0%(GC)
Packaging: 25g
Price: $49
Updated: 2024/03/01

TRC

Product number: D472660
Product name: 4,5-Dimethyl-1,3-dioxol-2-one
Packaging: 100g
Price: $395
Updated: 2021/12/16

Matrix Scientific

Product number: 075732
Product name: 4,5-Dimethyl-1,3-dioxol-2-one
Purity: 95+%
Packaging: 100g
Price: $399
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK373976
Product name: 4,5-Dimethyl-1,3-dioxol-2-one
Purity: 99%
Packaging: 5g
Price: $64
Updated: 2021/12/16

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4,5-Dimethyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

4,5-Dimethyl-1,3-dioxol-2-one is a dioxolanone derivative used in the preparation of synthetic chemotherapeutic antibiotics such as Prulifloxacin (P838885).

Application

4,5-Dimethyl-1,3-dioxol-2-one is a kind of important medicine intermediate, is mainly used in the modification of many medicines, to synthesize, has optically active chiral drug, thereby improves largely drug effect, reduces drug side effect.

Synthesis

1. distillation column is being housed, air set pipe, mechanical stirrer, add 3-hydroxy-2-butanone 88g, methylcarbonate 90g, tirethylene glycol dme 264g and sodium propylate 0.88g in the three-necked flask of thermometer, at 60-65 ℃ of reacting by heating mixture, carry out transesterification reaction 6h, the methyl alcohol of generation is removed in synchronous distillation, obtains carbonic acid monomethyl 3-hydroxy-2-butanone base ester.
2. improve reaction mixture temperature to 110-115 ℃, keep this thermotonus 5h, continue to steam the by products such as methyl alcohol.
3., after reaction finishes, reaction mixture is to room temperature, add concentrated hydrochloric acid with the neutralization reaction catalyzer to reaction mixture pH value in 7 left and right. After methylcarbonate is reclaimed in fractionation, the underpressure distillation aliphatic ether is appropriate.The distillation residuum is cooled to 0-5 ℃, and crystallization, filtration, obtain product 4,5-dimethyl-1,3-dioxole-2-ketone crude product 62.34g.
4. add recrystallization solvent and 0.62g gac in crude product, be heated to 80 ℃ of return stirring 0.5-1h, filtered while hot, filtrate 60 ℃ of lower evaporation concentration to after having mass crystallization to separate out, adopt cooling bath cooling concentration liquid to 0-5 ℃, the gained solids is dried 2h at 50 ℃ of lower normal pressures.
Can obtain highly purified 4,5-Dimethyl-1,3-dioxol-2-one white crystal, these are highly purified 4 years old, 5-dimethyl-1, the quality of 3-dioxole-2-ketone is 53.88g, yield is 47.26% (calculating with the 3-hydroxy-2-butanone), purity (high performance liquid chromatography) is 99.0%, and fusing point is 77-78 ℃.

4,5-Dimethyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dimethyl-1,3-dioxol-2-one Suppliers

Americas 1 Canada 2 China 350 Czech Republic 1 Europe 3 Germany 4 India 22 Japan 7 Slovakia 1 South Korea 1 United Kingdom 11 United States 35 Global 438

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View Lastest Price from 4,5-Dimethyl-1,3-dioxol-2-one manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99.5%min GC
Supply Ability: 10000kg
Release date: 2021-11-19

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Olmesartan Medoxomil Impurity 37 37830-90-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-14

37830-90-3, 4,5-Dimethyl-1,3-dioxol-2-oneRelated Search:

Acetone oxime Dimethyl sulfide Dimethyl phthalate Dimethyl fumarate Dimethyl ether Selenium dioxide 1,4-Dioxane Methyl cyclopentenolone Dimethyl sulfoxide N,N-Dimethylformamide DIMETHYLGLYOXIME DISODIUM SALT 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ETHANE Olmesartan 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

4,5-DIMETHYL-1,3-DIOXOL-2-ONE

1,3-DIOXOL-2-ONE, 4,5-DIMETHYL-

DIMETHYLDIOXOLONE

4,5-DIMETHYL-1,3-DIOXOLENE-2-ONE (DMDO)

5-Dimethyl-1,3-dioxol-2-one

4,5-Dimethyl-1,3-dioxolen-3-one

4,5-Dimethyl-1,3-dioxolen-2-one

4,5-dimethyl-2-oxo-1,3-dioxolene

DMDO

DMDO (4,5-DIMETHYL-1,3-DIOXOL-2-ONE)

4,5-DIMETHYL-1,3-DIOXAL-2-ONE

4,5-DIMETHYL-1,3-DIOXOL-2-ONE (DMDO)

4,5-DIMETHYL-1,3-DIOXOL-2-ONE(OR DIMETHYLDIOXOLONE)

4,5-DIMETHYL-1,3-DIOXOL-2-ONE 99+%

4,5-Dimethyl-1,3-dioxocyclopenten-2-one

4,5-DIMETHYL-1,3-DIOXO-2-ONE

4,5-Dimethyl-1,3-dioxolen-2-one(DDO)

Carbonic acid 1,2-dimethylvinylene ester

Carbonic acid 2-butene-2,3-diyl ester

Dimethyl vinylene carbonate

Dimethylvinylene carbonate

4,5-dimethyl-1,3-dioxa-4-cyclopentene-2-one

4,5-Dimethyl-1,3-dio

4,5-Dimethyl-1,3-dioxol-2-one dimethyldioxolone ethyldiox

3-dioxol-2-one

diMethyl-2H-1,3-dioxol-2-one

4-5-Methyl-l,3-dioxocyclopenten-2–one

4,5-Dimethyl-1,3-dioxolen-3-one(DMDO)

4,5-dimethyl 1,3-2 oxygen heterocycle pentene-2-ketone

Olmesartan Impurity 54

AZATMint-A

Olmesartan Medoxomil Impurity 37

Olmesartan DMDO-CL Impurity Ⅱ

ORDIMETHYLDIOXOLONE

4,5-Dimethyl-1,3-dioxol-2-one&gt

Olmesartan DMDO-Cl Impurity Ⅴ

Olmesartan Dimethyl Impurity

4,5-Dimethyl-1,3-dioxol-2-one USP/EP/BP

4,5-dimethyl-l,3-dioxolene-2-one (DMDO)

4,5-Dimethyl-1,3-dioxole-2-one(DMDO)

4.5 Dimethyl 1.3 dioxane 2-one

4,5-Dimethy-1,3-dioxol-2-one(DMDO)

4,5-dimethyl-1,3-dioxolane-2-one

37830-90-3

Pharmaceutical Intermediates

Agricultural chemicals(bactericide)

Oxygen cyclic compounds

Fluorobenzene