Glucagon Receptor Antagonist I
- Product Name
- Glucagon Receptor Antagonist I
- CAS No.
- 438618-32-7
- Chemical Name
- Glucagon Receptor Antagonist I
- Synonyms
- hGCGR Antagonist;Glucagon Receptor Antagonist I;Glucagon receptor antagonist-7;Glucagon receptor antagonists-7;Butanamide, N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-2-ethyl-;N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide
- CBNumber
- CB23136786
- Molecular Formula
- C20H30N2OS
- Formula Weight
- 346.53
- MOL File
- 438618-32-7.mol
Glucagon Receptor Antagonist I Property
- Boiling point:
- 517.8±50.0 °C(Predicted)
- Density
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- White crystalline solid.
- pka
- 13.46±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- 21223
- Product name
- Glucagon Receptor Antagonist I
- Purity
- ≥99%
- Packaging
- 500μg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 21223
- Product name
- Glucagon Receptor Antagonist I
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- 21223
- Product name
- Glucagon Receptor Antagonist I
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $476
- Updated
- 2024/03/01
- Product number
- 8227CC
- Product name
- GlucagonReceptorAntagonistI
- Packaging
- 5mg
- Price
- $583
- Updated
- 2021/12/16
- Product number
- 8227CC
- Product name
- GlucagonReceptorAntagonistI
- Packaging
- 1mg
- Price
- $233
- Updated
- 2021/12/16
Glucagon Receptor Antagonist I Chemical Properties,Usage,Production
Description
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
Uses
Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels[1].
References
[1] Qureshi SA, et al., A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73. DOI:10.2337/diabetes.53.12.3267
Glucagon Receptor Antagonist I Preparation Products And Raw materials
Raw materials
Preparation Products
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