ChemicalBook > CAS DataBase List > Eprinomectin

Eprinomectin

Product Name
Eprinomectin
CAS No.
123997-26-2
Chemical Name
Eprinomectin
Synonyms
Emamectin B1 Benzoate;eprinex;Eprinomectin (Mixture of B1a and B1b);MK 397;EPRINOMECTIN;Eprinomection;EprinomectinB1;Acetaminobamectin;Acetaminoabamectin;acetamido abamectin
CBNumber
CB2316329
Molecular Formula
C50H75NO14
Formula Weight
914.1288
MOL File
123997-26-2.mol
More
Less

Eprinomectin Property

Melting point:
163-166°C
Density 
1.23
Flash point:
2 °C
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form 
Solid
color 
White to off-white
Stability:
Hygroscopic
More
Less

Safety

Hazard Codes 
F,Xn,N,T
Risk Statements 
11-20/21/22-36-62-50/53-25-63
Safety Statements 
26-36/37-16-61-60-45
RIDADR 
UN 2811
WGK Germany 
3
HS Code 
2941906000
Toxicity
LD50 orally in mice: 24 mg/kg (Jones)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32526
Product name
Eprinomectin
Purity
PESTANAL
Packaging
100mg
Price
$238
Updated
2024/03/01
Sigma-Aldrich
Product number
1237752
Product name
Eprinomectin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$678
Updated
2024/03/01
Cayman Chemical
Product number
28182
Product name
Eprinomectin
Packaging
50mg
Price
$66
Updated
2023/06/20
Cayman Chemical
Product number
28182
Product name
Eprinomectin
Packaging
100mg
Price
$118
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR1766
Product name
Eprinomectin
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$180
Updated
2024/03/01
More
Less

Eprinomectin Chemical Properties,Usage,Production

Description

Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%).Eprinomectin was developed as a topical endectocide for all categories of cattle including lactating dairy cattle, and the process by which eprinomectin was selected for further development has been described (90). Briefly, several hundred avermectin/ milbemycin analogues were screened in a sheep model for efficacy against a range of endoparasites and in lactating dairy cows for a low milk:plasma partitioning ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin, by comparison, partitions equally between milk and plasma.

Description

Eprinomectin is an avermectin with anthelmintic and insecticidal activities. It is comprised of eprinomectin B1a and eprinomectin B1b . Eprinomectin (≥0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg. Formulations containing eprinomectin have been used in the treatment and control of a variety of endo- and ectoparasites in cattle.

Chemical Properties

Crystalline Solid

Uses

A mixture of semi-synthetic Avermectins; containing 90% or more of component B1a and 10% or less of component B1b. Antiparasitic

Uses

Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect.

Uses

A mixture of Eprinomectin B1a and B1b showing anti-anthelintic activity

brand name

Eprinex [Veterinary](Merial).

Veterinary Drugs and Treatments

In cattle, eprinomectin is indicated for a variety gastrointestinal roundworms including adult and L4 stages of Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei and colubriformis, Cooperia oncophora/punctata/surnabada, Nematodirus helvetianus, Oesophagostomum radiatum, Bunostomum phlebotomum, and Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn flies (for 7 days after treatment), and lungworms (Dictyocaulus vivaparus—for 21 days after treatment).
Topical eprinomectin may be useful for the topical treatment of ear mites (Psoroptes cuniculi) in rabbits. One small study (6 subjects) showed partial response when rabbits were dosed at 5 mg/kg topically, twice at 14 day intervals. (Ulutas, Voyvoda et al. 2005)

Toxicity evaluation

Acute oral LD50 for rats: 55mg/kg

Eprinomectin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Eprinomectin Suppliers

Canada 1 China 213 Europe 2 Germany 2 India 4 Japan 2 Switzerland 1 United Kingdom 5 United States 22 Global 252
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Tecoland Corporation
Tel
--
Fax
--
Email
info@tecoland.com
Country
United States
ProdList
275
Advantage
50
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
More
Less

View Lastest Price from Eprinomectin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Eprinomectin 123997-26-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
100kg
Release date
2021-10-21
Henan Suikang Pharmaceutical Co.,Ltd.
Product
EPRINOMECTIN 123997-26-2
Price
US $0.00/kg
Min. Order
1kg
Purity
95.0%
Supply Ability
1tons
Release date
2024-04-26
Hebei Yanxi Chemical Co., Ltd.
Product
Eprinomectin 123997-26-2
Price
US $0.00/kg
Min. Order
1kg
Purity
CP2015
Supply Ability
20tons
Release date
2023-09-20

123997-26-2, EprinomectinRelated Search:

Abamectin Ipriflavone Emamectin Nystatin Ectoine Brexpiprazole Etonogestrel EPROSARTAN Erythromycin Estolate Etodolac Eplerenone Avermectin A1a, 4-(acetylamino)-5-O-demethyl-25-de(1-methylpropyl)-4-deoxy-25-(1-methylethyl)-, (4R)- Ferric acetylacetonate TERT-BUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE 2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE

  • EPRINOMECTIN
  • (4''R)-4''-(ACETYLAMINO)-4''-DEOXY-AVERMECTIN B1
  • Emamectin B1 Benzoate
  • EPRINOMECTIN VETRANAL
  • EprinomectinB1
  • Avermectin B1, 4-(acetylamino)-4-deoxy-, (4R)-
  • (4''r)-4''-(acetylamino)-4''-deoxy-avermectin b1solution
  • eprinex
  • eprinomectin (mixure of eprinomectin b1a and b1b minor component)
  • eprinomectin solution
  • MK 397
  • Acetaminoabamectin
  • Eprinomectin, 100 ng/ in Acetonitril , Vetranal
  • Eprinomection
  • Eprinomectin (300 mg) (COLD SHIPMENT REQUIRED)
  • MK-397, 4''R-epiacetylaMino-4''-deoxyaverMectin B1
  • EprinoMectin-d3 (Mixture of B1a and B1b)
  • Eprinomectin@100 μg/mL in Acetonitrile
  • Eprinomectin (Mixture of B1a and B1b)
  • acetamido abamectin
  • Eprinomectin (COLD SHIPMENT REQUIRED) (1237752)
  • Phenyl Acetate Impurity 12
  • Acetaminobamectin
  • CA13187000 Eprinomectin
  • Eprinomectin 100 μg/ml Acetonitrile
  • Eprinomectin in Acetonitrile
  • 123997-26-2
  • C50H75NO14C49H73NO14
  • C50H75NO14
  • C49H72NO14R
  • C49H73NO14C50H75NO14
  • Chiral Reagents
  • Heterocycles