2,4-Difluorophenol
- Product Name
- 2,4-Difluorophenol
- CAS No.
- 367-27-1
- Chemical Name
- 2,4-Difluorophenol
- Synonyms
- 4-Difluorophenol;2,4-DIFLUOROPHENOL;2,4-Difluorophenol>Phenol, 2,4-difluoro-;2,4-Difluorophenol 98%;2,4- twodifluoro phenol;2,4-Difluorophenol, 99+%;2,4-Difluorophenol, 98+%;2,4-Difluorophenol ISO 9001：2015 REACH;2,4-Difluorophenol 98%, 4-Difluorophenol 98%
- CBNumber
- CB2318257
- Molecular Formula
- C6H4F2O
- Formula Weight
- 130.09
- MOL File
- 367-27-1.mol
2,4-Difluorophenol Property
- Melting point:
- 22.4 °C (lit.)
- Boiling point:
- 52-53 °C/19 mmHg (lit.)
- Density
- 1.362 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.486(lit.)
- Flash point:
- 134 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.72±0.18(Predicted)
- form
- powder to lump to clear liquid
- color
- White or Colorless to Yellow
- Specific Gravity
- 1.362
- Water Solubility
- slightly soluble
- BRN
- 1934803
- InChIKey
- NVWVWEWVLBKPSM-UHFFFAOYSA-N
- CAS DataBase Reference
- 367-27-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,4-Difluorophenol(367-27-1)
Safety
- Hazard Codes
- Xn,Xi,C,F
- Risk Statements
- 20/21/22-37/38-41-34-11-36/37/38
- Safety Statements
- 26-36/37/39-45-16
- RIDADR
- 1992
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29081000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 233269
- Product name
- 2,4-Difluorophenol
- Purity
- 99%
- Packaging
- 5g
- Price
- $50.61
- Updated
- 2025/07/31
- Product number
- 233269
- Product name
- 2,4-Difluorophenol
- Purity
- 99%
- Packaging
- 25g
- Price
- $227.5
- Updated
- 2025/07/31
- Product number
- D1832
- Product name
- 2,4-Difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- D1832
- Product name
- 2,4-Difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- D446355
- Product name
- 2,4-Difluorophenol
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
2,4-Difluorophenol Chemical Properties,Usage,Production
Chemical Properties
clear yellow-green liquid after melting
Uses
2,4-Difluorophenol, is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is also used in the synthesis of new α-Phenoxyacetamide derivatives, acting as type III secretion system of Pseudomonas aeruginosa PAO1, a gram-negative bacteria.
Uses
2,4-Difluorophenol has been used:
- as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine
- in the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye
Synthesis
144025-03-6
367-27-1
General procedure for the synthesis of 2,4-difluorophenol from 2,4-difluorophenylboronic acid: arylboronic acid (1 mmol), 30% aqueous H2O2 solution (0.2 mL), ZnO nanocatalyst (5 mol%, sample ZnO-1), and 2 mL of water were stirred and mixed in a 50 mL round-bottomed flask at room temperature and under aerobic conditions. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over Na2SO4. The solvent was removed by rotary evaporator under reduced pressure. The crude product was purified by silica gel (100-200 mesh) column chromatography (hexane/ethyl acetate, 9:1) to afford the target product 2,4-difluorophenol. The product structure was confirmed by 1H NMR and 13C NMR.
References
[1] Applied Catalysis A: General, 2018, vol. 562, p. 58 - 66
[2] Tetrahedron Letters, 2015, vol. 56, # 14, p. 1780 - 1783
[3] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 633 - 634
2,4-Difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Difluorophenol Suppliers
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- Country
- Belgium
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- 6772
- Advantage
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View Lastest Price from 2,4-Difluorophenol manufacturers
- Product
- 2,4-Difluorophenol 367-27-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-28
- Product
- 2,4-Difluorophenol 367-27-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-18
- Product
- 2,4-Difluorophenol 367-27-1
- Price
- US $9.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-23