ChemicalBook > CAS DataBase List > 2,4-Difluorophenol

2,4-Difluorophenol

Product Name
2,4-Difluorophenol
CAS No.
367-27-1
Chemical Name
2,4-Difluorophenol
Synonyms
4-Difluorophenol;2,4-DIFLUOROPHENOL;2,4-Difluorophenol>Phenol, 2,4-difluoro-;2,4-Difluorophenol 98%;2,4- twodifluoro phenol;2,4-Difluorophenol, 99+%;2,4-Difluorophenol, 98+%;2,4-Difluorophenol ISO 9001：2015 REACH;2,4-Difluorophenol 98%, 4-Difluorophenol 98%
CBNumber
CB2318257
Molecular Formula
C6H4F2O
Formula Weight
130.09
MOL File
367-27-1.mol
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2,4-Difluorophenol Property

Melting point:
22.4 °C (lit.)
Boiling point:
52-53 °C/19 mmHg (lit.)
Density 
1.362 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.486(lit.)
Flash point:
134 °F
storage temp. 
Inert atmosphere,Room Temperature
pka
8.72±0.18(Predicted)
form 
powder to lump to clear liquid
color 
White or Colorless to Yellow
Specific Gravity
1.362
Water Solubility 
slightly soluble
BRN 
1934803
InChIKey
NVWVWEWVLBKPSM-UHFFFAOYSA-N
CAS DataBase Reference
367-27-1(CAS DataBase Reference)
NIST Chemistry Reference
2,4-Difluorophenol(367-27-1)
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Safety

Hazard Codes 
Xn,Xi,C,F
Risk Statements 
20/21/22-37/38-41-34-11-36/37/38
Safety Statements 
26-36/37/39-45-16
RIDADR 
1992
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
3
PackingGroup 
III
HS Code 
29081000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233269
Product name
2,4-Difluorophenol
Purity
99%
Packaging
5g
Price
$50.61
Updated
2025/07/31
Sigma-Aldrich
Product number
233269
Product name
2,4-Difluorophenol
Purity
99%
Packaging
25g
Price
$227.5
Updated
2025/07/31
TCI Chemical
Product number
D1832
Product name
2,4-Difluorophenol
Purity
>98.0%(GC)
Packaging
5g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
D1832
Product name
2,4-Difluorophenol
Purity
>98.0%(GC)
Packaging
25g
Price
$111
Updated
2025/07/31
TRC
Product number
D446355
Product name
2,4-Difluorophenol
Packaging
10g
Price
$120
Updated
2021/12/16
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2,4-Difluorophenol Chemical Properties,Usage,Production

Chemical Properties

clear yellow-green liquid after melting

Uses

2,4-Difluorophenol, is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is also used in the synthesis of new α-Phenoxyacetamide derivatives, acting as type III secretion system of Pseudomonas aeruginosa PAO1, a gram-negative bacteria.

Uses

2,4-Difluorophenol has been used:

  • as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine
  • in the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye

Synthesis

144025-03-6

367-27-1

General procedure for the synthesis of 2,4-difluorophenol from 2,4-difluorophenylboronic acid: arylboronic acid (1 mmol), 30% aqueous H2O2 solution (0.2 mL), ZnO nanocatalyst (5 mol%, sample ZnO-1), and 2 mL of water were stirred and mixed in a 50 mL round-bottomed flask at room temperature and under aerobic conditions. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over Na2SO4. The solvent was removed by rotary evaporator under reduced pressure. The crude product was purified by silica gel (100-200 mesh) column chromatography (hexane/ethyl acetate, 9:1) to afford the target product 2,4-difluorophenol. The product structure was confirmed by 1H NMR and 13C NMR.

References

[1] Applied Catalysis A: General, 2018, vol. 562, p. 58 - 66
[2] Tetrahedron Letters, 2015, vol. 56, # 14, p. 1780 - 1783
[3] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 633 - 634

2,4-Difluorophenol Preparation Products And Raw materials

Raw materials

2,4-Dichloronitrobenzene

Preparation Products

3-(2,4-difluorophenoxy)propanoic acid
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2,4-Difluorophenol Suppliers

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View Lastest Price from 2,4-Difluorophenol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,4-Difluorophenol 367-27-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-28
Shaanxi Dideu Medichem Co. Ltd
Product
2,4-Difluorophenol 367-27-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-06-18
Henan Fengda Chemical Co., Ltd
Product
2,4-Difluorophenol 367-27-1
Price
US $9.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-23

367-27-1, 2,4-DifluorophenolRelated Search:

4-Fluorophenol 2,6-Dimethylphenol Xylenol 2,5-DINITROPHENOL 3,4-DIFLUOROPHENOL 2,3-Difluorophenol,98+%,2,3-DIFLUOROPHENOL 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Pentafluorophenol PENTAFLUOROPHENYL ACRYLATE FMOC-ASP(OTBU)-OPFP 2,4,6-Trifluorophenol PENTAFLUOROPHENOXYACETIC ACID PENTAFLUOROPHENYL METHACRYLATE 2,3,4-TRIFLUOROPHENOL 9-FLUORENYLMETHYL PENTAFLUOROPHENYL CARBONATE 2,3,4,5,6-PENTAFLUOROANISOLE 2,3,4-Trifluoroanisole FMOC-GLY-OPFP

  • 2,4-Difluorophenol 98%
  • 4-Difluorophenol
  • 2,4- twodifluoro phenol
  • 2,4-Difluorophenol 98%, 4-Difluorophenol 98%
  • 2,4-DIFLUOROPHENOL
  • Phenol, 2,4-difluoro-
  • 2,4-Difluorophenol, 98+%
  • 2,4-Difluorophenol, 99+%
  • 2,4-Difluorophenol&gt
  • 2,4-Difluorophenol ISO 9001：2015 REACH
  • 367-27-1
  • C6H4OF2
  • C6H4F2O
  • Oxygen Compounds
  • Phenols
  • Organic Building Blocks
  • Building Blocks
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
  • Fluoro-Aromatics
  • Aromatic Phenols
  • Fluorobenzene
  • Phenol&Thiophenol&Mercaptan
  • Fluorophenols
  • Heterocyclic Acids,Quinolines