2,6-Difluorophenol
- Product Name
- 2,6-Difluorophenol
- CAS No.
- 28177-48-2
- Chemical Name
- 2,6-Difluorophenol
- Synonyms
- 2,6-Difluorphenol;2,6-DIFLUOROPHENOL;Phenol, 2,6-difluoro-;2,6-Difluorophenol>2,6-Difluorophenol98%;2,6-Difluorophenol 98%;2,6-Difluorophenol, 95%;2,6-DIFLUOROPHENOL: 96.5%;2,6-Difluorophenol ISO 9001：2015 REACH;2,6-Difluorophenol, 98%, for synthesis
- CBNumber
- CB2319067
- Molecular Formula
- C6H4F2O
- Formula Weight
- 130.09
- MOL File
- 28177-48-2.mol
2,6-Difluorophenol Property
- Melting point:
- 38-41 °C (lit.)
- Boiling point:
- 59-61 °C/17 mmHg (lit.)
- Density
- 1,27 g/cm3
- Flash point:
- 138 °F
- storage temp.
- 2-8°C
- solubility
- ethanol: soluble50mg/mL, clear, colorless to light yellow
- form
- Crystalline Low Melting Solid
- pka
- 7.45±0.10(Predicted)
- color
- Colorless
- Water Solubility
- Slightly soluble in water. Soluble in ethanol.
- BRN
- 2043613
- InChI
- InChI=1S/C6H4F2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H
- InChIKey
- CKKOVFGIBXCEIJ-UHFFFAOYSA-N
- SMILES
- C1(O)=C(F)C=CC=C1F
- CAS DataBase Reference
- 28177-48-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,6-Difluorophenol(28177-48-2)
Safety
- Hazard Codes
- F,Xi,Xn
- Risk Statements
- 11-36/37/38-20/21/22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
- F
- 10
- Hazard Note
- Irritant
- HazardClass
- 4.1
- PackingGroup
- II
- HS Code
- 29081000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 264466
- Product name
- 2,6-Difluorophenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $61.84
- Updated
- 2025/07/31
- Product number
- D2015
- Product name
- 2,6-Difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- D2015
- Product name
- 2,6-Difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $253
- Updated
- 2025/07/31
- Product number
- D445630
- Product name
- 2,6-Difluorophenol
- Packaging
- 25g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 005564
- Product name
- 2,6-Difluorophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $74
- Updated
- 2021/12/16
2,6-Difluorophenol Chemical Properties,Usage,Production
Chemical Properties
colorless crystalline low melting solid
Uses
2,6-Difluorophenol undergoes oxidative polymerization in the presence of the Fe-N,N?-bis(salicylidene)ethylenediamine (salen) complex (catalyst) and hydrogen peroxide (oxidizing agent) to give poly(2,6-difluoro-1,4-phenylene oxide). It is also used as pharmaceutical intermediates.
Synthesis
437-82-1
28177-48-2
General procedure for the synthesis of 2,6-difluorophenol from 2,6-difluoroanisole: 2,6-difluoroanisole (4.00 mL, 33.9 mmol) was dissolved in acetonitrile (50 mL), and trimethylchlorosilane (8.80 mL, 102 mmol) and sodium iodide (15.0 g, 100 mmol) were added sequentially. The reaction mixture was heated to 100 °C for 5 hours. After completion of the reaction, it was cooled to room temperature and the solvent was removed by evaporation under reduced pressure. Water (40 mL) was added to the residue and extracted with dichloromethane (30 mL x 3). The organic phases were combined and washed sequentially with water (40 mL) and saturated brine (40 mL), and then dried over anhydrous sodium sulfate. After filtration, the solvent was removed by evaporation under reduced pressure to obtain the crude product. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v = 6/1) to afford the yellow oily product 2,6-difluorophenol (2.2 g, 50% yield).
References
[1] Patent: CN105384687, 2016, A. Location in patent: Paragraph 0479; 0480; 0481; 0482
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
2,6-Difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Difluorophenol Suppliers
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View Lastest Price from 2,6-Difluorophenol manufacturers
- Product
- 2,6-Difluorophenol 28177-48-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-26
- Product
- 2, 6-Difluorophenol 28177-48-2
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-13
- Product
- 2,6-Difluorophenol; Difluorophenol 28177-48-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10mt
- Release date
- 2020-03-25