ChemicalBook > CAS DataBase List > 4-Bromo-3,5-dimethylisoxazole

4-Bromo-3,5-dimethylisoxazole

Product Name: 4-Bromo-3,5-dimethylisoxazole
CAS No.: 10558-25-5
Chemical Name: 4-Bromo-3,5-dimethylisoxazole
Synonyms: SKL268;BUTTPARK 33\06-98;TIMTEC-BB SBB003784;4-Bromo-dimethylisoxazole;4-Bromo-3,5-dimethylisoxa...;4-BROMO-3,5-DIMETHYLISOXAZOLE;Isoxazole, 4-broMo-3,5-diMethyl-;4-Bromo-3,5-dimethylisoxazole >4-BROMO-3,5-DIMETHYLISOXAZOLE 97%;4-Bromo-3,5-dimethylisoxazole,97%
CBNumber: CB2339447
Molecular Formula: C5H6BrNO
Formula Weight: 176.01
MOL File: 10558-25-5.mol

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4-Bromo-3,5-dimethylisoxazole Property

Boiling point:: 176 °C(lit.)
Density: 1.478 g/mL at 25 °C(lit.)
refractive index: n20/D 1.486(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
pka: -2.35±0.28(Predicted)
form: clear liquid
color: Colorless to Light orange to Yellow
Sensitive: Light Sensitive
BRN: 108522
InChI: InChI=1S/C5H6BrNO/c1-3-5(6)4(2)8-7-3/h1-2H3
InChIKey: GYHZPSUAMYIFQD-UHFFFAOYSA-N
SMILES: O1C(C)=C(Br)C(C)=N1
CAS DataBase Reference: 10558-25-5(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
Hazard Note: Keep Cold/Light Sensitive
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 544299
Product name: 4-Bromo-3,5-dimethylisoxazole
Purity: 95%
Packaging: 1g
Price: $21.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 544299
Product name: 4-Bromo-3,5-dimethylisoxazole
Purity: 95%
Packaging: 5g
Price: $63.4
Updated: 2023/06/20

TCI Chemical

Product number: B3519
Product name: 4-Bromo-3,5-dimethylisoxazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $20
Updated: 2024/03/01

TCI Chemical

Product number: B3519
Product name: 4-Bromo-3,5-dimethylisoxazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $79
Updated: 2024/03/01

TRC

Product number: B691648
Product name: 4-Bromo-3,5-dimethylisoxazole
Packaging: 1g
Price: $75
Updated: 2021/12/16

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4-Bromo-3,5-dimethylisoxazole Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

4-Bromo-3,5-dimethylisoxazole may be used in the preparation of (tert-butyldimethylsilyl)-(3,5-dimethylisoxazol-4-yl)phenylamine and 3,3′,5,5′-tetramethyl-4,4′-diisoxazole.[21}

General Description

4-Bromo-3,5-dimethylisoxazole is also known as 3,5-dimethyl-4-bromoisoxazole.

Synthesis

300-87-8

10558-25-5

The general procedure for the synthesis of 4-bromo-3,5-dimethylisoxazole from 3,5-dimethylisoxazole is as follows: 1. Preparation of intermediate 105 (4-bromo-3,5-dimethyl-1,2-oxazole): DMF (53 mL) was added to a 250 mL round-bottomed flask fitted with a magnetic stirrer. 2. 3,5-dimethyl-1,2-oxazole (5.3 g, 54.57 mmol) and N-iodosuccinimide (11.659 g, 65.49 mmol) were sequentially added to the stirred DMF. 3. After completion of the addition, the reaction mixture was heated to 75°C and maintained for 3 hours. 4. Upon completion of the reaction, the mixture was diluted with ethyl acetate (100 mL). 5. The organic layer was washed sequentially with saturated NaHCO3 solution (100 mL), sodium thiosulfate solution (100 mL), water (200 mL) and brine (100 mL). 6. The organic layer was dried over anhydrous Na2SO4 and then concentrated under reduced pressure to remove the solvent to afford the target product 4-bromo-3,5-dimethyl-1,2-oxazole (6.1 g, 63.4% yield).

References

[1] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 148; 149
[2] Rend. Ist. lomb., 1936, vol. 69, p. 587,600

4-Bromo-3,5-dimethylisoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-3,5-dimethylisoxazole manufacturers

Career Henan Chemical Co

Product: 4-Bromo-3,5-dimethylisoxazole 10558-25-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

10558-25-5, 4-Bromo-3,5-dimethylisoxazoleRelated Search:

Isoxazole ISOXAFLUTOLE Sulfisoxazole Chlorobromoisocyanurate Sulfamethoxazole 3,5-Dimethylisoxazole 2-Bromopropane Sulfadoxine Bromine 4-BROMO-3,5-DIPHENYLISOXAZOLE 3-BROMO-4,5-DIMETHYLISOXAZOLE 4-Bromo-3,5-dimethylisoxazole bromo-Dragonfly 4-BROMO-5-(4-BROMOPHENYL)-3-PHENYLISOXAZOLE 4-BROMO-5-(4-METHOXYPHENYL)-3-PHENYLISOXAZOLE SPECS AQ-776/42801685 4-BROMO-5-(4-FLUOROPHENYL)-3-PHENYLISOXAZOLE 4-BROMO-3-METHYLISOXAZOLE-5-CARBOXYLIC ACID

BUTTPARK 33\06-98

4-BROMO-3,5-DIMETHYLISOXAZOLE

4-BROMO-3,5-DIMETHYLISOXAZOLE 97%

Isoxazole, 4-broMo-3,5-diMethyl-

4-Bromo-3,5-dimethylisoxazole, tech.

4-Bromo-3,5-dimethylisoxazole,97%

4-Bromo-3,5-dimethylisoxa...

TIMTEC-BB SBB003784

4-Bromo-dimethylisoxazole

4-Bromo-3,5-dimethylisoxazole &gt

SKL268

10558-25-5

105558-25-5

C5H6BrNO

C5H5BrNO

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