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4-Bromo-3,5-dimethylisoxazole

Product Name
4-Bromo-3,5-dimethylisoxazole
CAS No.
10558-25-5
Chemical Name
4-Bromo-3,5-dimethylisoxazole
Synonyms
SKL268;BUTTPARK 33\06-98;TIMTEC-BB SBB003784;4-Bromo-dimethylisoxazole;4-Bromo-3,5-dimethylisoxa...;4-BROMO-3,5-DIMETHYLISOXAZOLE;Isoxazole, 4-broMo-3,5-diMethyl-;4-Bromo-3,5-dimethylisoxazole >4-BROMO-3,5-DIMETHYLISOXAZOLE 97%;4-Bromo-3,5-dimethylisoxazole,97%
CBNumber
CB2339447
Molecular Formula
C5H6BrNO
Formula Weight
176.01
MOL File
10558-25-5.mol
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4-Bromo-3,5-dimethylisoxazole Property

Boiling point:
176 °C(lit.)
Density 
1.478 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.486(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
pka
-2.35±0.28(Predicted)
form 
clear liquid
color 
Colorless to Light orange to Yellow
Sensitive 
Light Sensitive
BRN 
108522
InChI
InChI=1S/C5H6BrNO/c1-3-5(6)4(2)8-7-3/h1-2H3
InChIKey
GYHZPSUAMYIFQD-UHFFFAOYSA-N
SMILES
O1C(C)=C(Br)C(C)=N1
CAS DataBase Reference
10558-25-5(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
Hazard Note 
Keep Cold/Light Sensitive
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
544299
Product name
4-Bromo-3,5-dimethylisoxazole
Purity
95%
Packaging
1g
Price
$21.9
Updated
2023/06/20
Sigma-Aldrich
Product number
544299
Product name
4-Bromo-3,5-dimethylisoxazole
Purity
95%
Packaging
5g
Price
$63.4
Updated
2023/06/20
TCI Chemical
Product number
B3519
Product name
4-Bromo-3,5-dimethylisoxazole
Purity
>98.0%(GC)
Packaging
1g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
B3519
Product name
4-Bromo-3,5-dimethylisoxazole
Purity
>98.0%(GC)
Packaging
5g
Price
$79
Updated
2024/03/01
TRC
Product number
B691648
Product name
4-Bromo-3,5-dimethylisoxazole
Packaging
1g
Price
$75
Updated
2021/12/16
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4-Bromo-3,5-dimethylisoxazole Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

4-Bromo-3,5-dimethylisoxazole may be used in the preparation of (tert-butyldimethylsilyl)-(3,5-dimethylisoxazol-4-yl)phenylamine and 3,3′,5,5′-tetramethyl-4,4′-diisoxazole.[21}

General Description

4-Bromo-3,5-dimethylisoxazole is also known as 3,5-dimethyl-4-bromoisoxazole.

Synthesis

300-87-8

10558-25-5

The general procedure for the synthesis of 4-bromo-3,5-dimethylisoxazole from 3,5-dimethylisoxazole is as follows: 1. Preparation of intermediate 105 (4-bromo-3,5-dimethyl-1,2-oxazole): DMF (53 mL) was added to a 250 mL round-bottomed flask fitted with a magnetic stirrer. 2. 3,5-dimethyl-1,2-oxazole (5.3 g, 54.57 mmol) and N-iodosuccinimide (11.659 g, 65.49 mmol) were sequentially added to the stirred DMF. 3. After completion of the addition, the reaction mixture was heated to 75°C and maintained for 3 hours. 4. Upon completion of the reaction, the mixture was diluted with ethyl acetate (100 mL). 5. The organic layer was washed sequentially with saturated NaHCO3 solution (100 mL), sodium thiosulfate solution (100 mL), water (200 mL) and brine (100 mL). 6. The organic layer was dried over anhydrous Na2SO4 and then concentrated under reduced pressure to remove the solvent to afford the target product 4-bromo-3,5-dimethyl-1,2-oxazole (6.1 g, 63.4% yield).

References

[1] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 148; 149
[2] Rend. Ist. lomb., 1936, vol. 69, p. 587,600

4-Bromo-3,5-dimethylisoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3,5-dimethylisoxazole Suppliers

Americas 1 Belgium 4 China 157 Czech Republic 1 Europe 1 France 1 Germany 4 India 23 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 16 United States 40 Global 253
Alfa Aesar, Thermo Fisher Scientific
Tel
--
Fax
--
Email
es@alfa.com
Country
Germany
ProdList
5123
Advantage
58
CHEMOS GmbH & Co. KG
Tel
--
Fax
--
Email
chemos@chemos.de
Country
Germany
ProdList
6727
Advantage
58
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 4-Bromo-3,5-dimethylisoxazole manufacturers

Career Henan Chemical Co
Product
4-Bromo-3,5-dimethylisoxazole 10558-25-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-05-24

10558-25-5, 4-Bromo-3,5-dimethylisoxazoleRelated Search:

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  • SKL268
  • 10558-25-5
  • 105558-25-5
  • C5H6BrNO
  • C5H5BrNO
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