Description
ChemicalBook > CAS DataBase List > D-(-)-Salicin

D-(-)-Salicin

Description
Product Name
D-(-)-Salicin
CAS No.
138-52-3
Chemical Name
D-(-)-Salicin
Synonyms
SALICIN;D-SALICIN;SALICOSIDE;WHITE WILLOW;Salicine;Salicylin;SALICIN(RG);SALICIN(SH);Salicin >Salicin CRS
CBNumber
CB2349192
Molecular Formula
C13H18O7
Formula Weight
286.28
MOL File
138-52-3.mol
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D-(-)-Salicin Property

Melting point:
196-202 °C
alpha 
-61.5 º (c=5, water)
Boiling point:
388.65°C (rough estimate)
Density 
1.4340
refractive index 
-62 ° (C=3, H2O)
storage temp. 
2-8°C
solubility 
36g/l
form 
Fine Crystalline Powder
pka
12.80±0.70(Predicted)
color 
White
Water Solubility 
36 g/L (15 ºC), 250 g/L (60 ºC)
Merck 
14,8324
BRN 
89593
Stability:
Stable, but light sensitive. Incompatible with strong oxidizing agents.
InChIKey
NGFMICBWJRZIBI-MICYEWLZSA-N
LogP
-1.232 (est)
CAS DataBase Reference
138-52-3(CAS DataBase Reference)
NIST Chemistry Reference
Salicin(138-52-3)
EPA Substance Registry System
.beta.-D-Glucopyranoside, 2-(hydroxymethyl)phenyl (138-52-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37-37-24/25-36
WGK Germany 
3
RTECS 
LZ5901700
3-10
TSCA 
Yes
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S0625
Product name
D-(?)-Salicin
Purity
≥99% (GC)
Packaging
5g
Price
$57.1
Updated
2024/03/01
Sigma-Aldrich
Product number
79588
Product name
D-(?)-Salicin
Purity
analytical standard
Packaging
100mg
Price
$230
Updated
2024/03/01
TCI Chemical
Product number
S0003
Product name
Salicin
Purity
>98.0%(HPLC)
Packaging
5g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
S0003
Product name
Salicin
Purity
>98.0%(HPLC)
Packaging
25g
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
A16524
Product name
D-(-)-Salicin, 99%
Packaging
5g
Price
$40.2
Updated
2024/03/01
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D-(-)-Salicin Chemical Properties,Usage,Production

Description

D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models.

Chemical Properties

white crystals or powder

Uses

analgesic, antipyretic

Uses

H1 antihistamine (nonsedating)

Uses

Standard substrate in evaluating enzyme Preparations contg b-glucosidase: Weidenhagen, Z. Ver. Zucker-Ind. 79, 591 (1929).

Uses

D-(-)-Salicin has been used:

  • to study its in vitro anticoagulant and antiplatelet activities
  • as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant
  • as a tastant in taste threshold assay
  • as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei

Definition

ChEBI: An aryl beta-D-glucoside that is the beta-D-glucoside of the phenolic hydroxy group of salicyl alcohol.

General Description

Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid. It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.

Biochem/physiol Actions

D-(?)-Salicin exerts anti-rheumatism and anti-inflammatory activities. It inhibits lipopolysaccharide (LPS) induced inflammation in in vitro and in vivo studies. It regulates different signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). It also regulates cytokines concentration such as tumor necrosis factor-alpha(TNF-α), interleukin-1β, interleukin-6, and interleukin-10.

Purification Methods

Crystallise D(-)-salicin from EtOAc, EtOH or water and sublime it at 190-195o/12mm. [Armour et al. J Chem Soc 412 1961, IR: Pearl & Darling J Org Chem 24 731 1959, Beilstein 17 III/IV 2986, 17/7 V 113.]

D-(-)-Salicin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-(-)-Salicin manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
D-(-)-Salicin 138-52-3
Price
US $0.00/KG
Min. Order
1KG
Purity
15%-98% HPLC
Supply Ability
1000KG
Release date
2022-09-20
PNP Biotech Co. Ltd
Product
Salicin 138-52-3
Price
US $0.00/kg
Min. Order
25kg
Purity
15%
Supply Ability
Inquiry
Release date
2022-09-16
PNP Biotech Co. Ltd
Product
White Willow Bark Extract 138-52-3
Price
US $0.00/kg
Min. Order
25kg
Purity
15%
Supply Ability
Inquiry
Release date
2022-09-16

138-52-3, D-(-)-SalicinRelated Search:


  • D-(-)-SALICIN
  • D-SALICIN
  • 2-(HYDROXYMETHYL)PHENYL-BETA-D-GLUCOPYRANOSIDE
  • 2-(HYDROXYMETHYL)PHENYL-BETA-D-GLUCOPYYRANOSIDE
  • 2-(HYDROXYMETHYL)PHENYL-BETA-D-GLUCOSIDE
  • 2-(Hydroxymethyl)phenyl hexopyranoside
  • SALICYLALDEHYDE-B-D-GLUCOSIDE
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  • SALICYL ALCOHOL GLUCOSIDE
  • SALICOSIDE
  • SALICIN
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  • SALIGENIN-B-D-GLYCOPYRANOSIDE
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  • Saligenin-beta-D-glucopyranoside
  • saligeninbeta-d-glucopyranoside
  • β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl
  • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
  • SALICIN(AHP)
  • SALICIN(RG)
  • Saligenin-β-D-glucopyranoside
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  • White Willow Bark P.E or Salicin
  • D-Salicin, natural
  • (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-(hydroxymethyl)-phenoxy)tetrahydro-2H-pyran-3,4,5-trio
  • Salicin from Plant Extract≥ 98% (HPLC)
  • Salicin/Salix alba extract
  • SALICIN(SH)
  • saligenin-β-glucopyranoside
  • saligenin glucoside
  • SALICIN ((2-HYDROXYMETHYL-PHENYL)-SS-D-GLUCOPYRANOSIDE)
  • D-(-)-SALICIN WITH HPLC
  • D-(-)-SALICIN hplc
  • Salix alba L.
  • 2-(Hydroxymethyl)phenyl-β-D-glucopyranoside, D(-)-Salicin
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  • o-(Hydroxymethyl)phenyl b-D-glucopyranoside
  • D-()-Salicin ,98%
  • 2-(Hydroxymethyl)phe
  • D(-)-Salicin, 99+% 25GR
  • (2R,3S,4S,5R,6S)-2-(HydroxyMethyl)-6-(2-(hydroxyMethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol
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  • Salicoside, Salicine
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