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Sodium tolmetin dihydrate

Product Name
Sodium tolmetin dihydrate
CAS No.
64490-92-2
Chemical Name
Sodium tolmetin dihydrate
Synonyms
Tolmene;McN 2559-21-98;TOLMELINSODIUM;tolmetinsodiumdihydrate;sodiumtolmetindihydrate;Tolmetin Sodium (500 mg);Tolmetin Sodium (1670502);Tormetine Sodium (Dihydrate);TolMetin sodiuM salt dehydrate;TOLMETIN SODIUM SALT DIHYDRATE
CBNumber
CB2352833
Molecular Formula
C15H14NO3.Na.2H2O
Formula Weight
315.3
MOL File
64490-92-2.mol
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Sodium tolmetin dihydrate Property

Melting point:
155-157 (dec.)
storage temp. 
-20°C Freezer
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Beige
Water Solubility 
Soluble in water
InChIKey
QQILXENAYPUNEA-UHFFFAOYSA-M
CAS DataBase Reference
64490-92-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-38
Safety Statements 
36
WGK Germany 
3
RTECS 
UX9280000
HS Code 
2933995500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1670502
Product name
Tolmetin sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$174.4
Updated
2024/03/01
Alfa Aesar
Product number
J62663
Product name
Tolmetin sodium salt dihydrate
Purity
98+%
Packaging
1g
Price
$43.65
Updated
2024/03/01
Alfa Aesar
Product number
J62663
Product name
Tolmetin sodium salt dihydrate
Purity
98+%
Packaging
5g
Price
$148.65
Updated
2024/03/01
Cayman Chemical
Product number
18195
Product name
Tolmetin (sodium salt hydrate)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18195
Product name
Tolmetin (sodium salt hydrate)
Purity
≥98%
Packaging
5g
Price
$116
Updated
2024/03/01
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Sodium tolmetin dihydrate Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

beta-adrenergic blocker

Uses

Anti-inflammatory.

Definition

ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.

Biological Activity

tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].

in vitro

tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].

in vivo

in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].

References

[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.
[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.
[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.
[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.

Sodium tolmetin dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium tolmetin dihydrate Suppliers

Zhangjiagang huamao Fine chemical Co.,Ltd.
Tel
0512-58327208; 13962221965
Fax
0512-58327206
Email
sales@huamao-chem.com
Country
China
ProdList
34
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
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Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
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Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
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60
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
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View Lastest Price from Sodium tolmetin dihydrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sodium tolmetin dihydrate 64490-92-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06
Hebei Weibang Biotechnology Co., Ltd
Product
Sodium tolmetin dihydrate 64490-92-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-05-24
Hebei Mojin Biotechnology Co., Ltd
Product
Sodium tolmetin dihydrate 64490-92-2
Price
US $500.00/g
Min. Order
100g
Purity
99%
Supply Ability
200ton
Release date
2023-07-25

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