2-Phenylacetamide
- Product Name
- 2-Phenylacetamide
- CAS No.
- 103-81-1
- Chemical Name
- 2-Phenylacetamide
- Synonyms
- Benzeneacetamide;PHENYLACETAMIDE;Phenylacetic acid amide;-Toluamide;α-Toluamide;Phenacetamide;ALPHA-TOLUAMIDE;2-Pheylacetamide;PHENYLETHANAMIDE;2-PHENYLACETAMIDE
- CBNumber
- CB2360953
- Molecular Formula
- C8H9NO
- Formula Weight
- 135.16
- MOL File
- 103-81-1.mol
2-Phenylacetamide Property
- Melting point:
- 156 °C
- Boiling point:
- 280-290 °C (dec.)
- Density
- 1.1031 (rough estimate)
- refractive index
- 1.5589 (estimate)
- storage temp.
- Refrigerator
- solubility
- Soluble in methanol.
- form
- Solid
- pka
- 16.21±0.40(Predicted)
- color
- Plates or leaflets
- Merck
- 14,7266
- InChI
- InChI=1S/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
- InChIKey
- LSBDFXRDZJMBSC-UHFFFAOYSA-N
- SMILES
- C1(CC(N)=O)=CC=CC=C1
- CAS DataBase Reference
- 103-81-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzeneacetamide(103-81-1)
- EPA Substance Registry System
- Benzeneacetamide (103-81-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 22-36
- Safety Statements
- 22-24/25-60-36-26
- RTECS
- AC7705000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29242990
- Toxicity
- LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- P0120
- Product name
- 2-Phenylacetamide
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- P0120
- Product name
- 2-Phenylacetamide
- Purity
- >98.0%(N)
- Packaging
- 500g
- Price
- $286
- Updated
- 2024/03/01
- Product number
- H60626
- Product name
- 2-Phenylacetamide, 99%
- Packaging
- 250mg
- Price
- $52.4
- Updated
- 2024/03/01
- Product number
- P335554
- Product name
- 2-Phenylacetamide
- Packaging
- 100g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- JK439749
- Product name
- 2-Phenylacetamide
- Purity
- 98%
- Packaging
- 100g
- Price
- $146
- Updated
- 2021/12/16
2-Phenylacetamide Chemical Properties,Usage,Production
Chemical Properties
2-Phenylacetamide, also known as alpha-toluamide or benzeneacetamide, belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. Pure crystals are plate shaped and colorless to white. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene.
Uses
In agriculture, 2-Phenylacetamid can be used in the production of many important intermediates of pesticides, such as carbamine. In the field of dyes: it can react with some monomers with color to produce some important raw materials for blue and purple dyes. In the field of fragrances, it can be used as an important raw material for the synthesis of certain spices and flavors. 2-Phenylacetamide can also be used in the synthesis of organometallic, organic peroxide, organic peroxide ester, and other compounds, and can be used as a crosslinking agent for polymers, a film forming agent for coatings, a plasticizer for plastics, etc.
Uses
2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.
Definition
ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid.
Preparation
Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide.
Synthesis Reference(s)
Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504
The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005
Organic Syntheses, Coll. Vol. 4, p. 760, 1963
Biological Activity
2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.
Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.]
2-Phenylacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Phenylacetamide manufacturers
- Product
- 2-Phenylacetamide 103-81-1
- Price
- US $10.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99.5
- Supply Ability
- 10 ton per month
- Release date
- 2024-04-18
- Product
- 2-Phenylacetamide 103-81-1
- Price
- US $10.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99.5
- Supply Ability
- 10 ton per month
- Release date
- 2024-04-18
- Product
- 2-Phenylacetamide 103-81-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2024-03-18