ChemicalBook > CAS DataBase List > CORTISTATIN-14

CORTISTATIN-14

Product Name: CORTISTATIN-14
CAS No.: 186901-48-4
Chemical Name: CORTISTATIN-14
Synonyms: CST-14;CST-14 (RAT);13)-disulfide;CORTISTATIN-14;CAS:186901-48-4;CORTISTATIN (RAT);CORTISTATIN (16-29);Cortistatin-14(mouse);Cortistatin14,Cortista;CORTISTATIN-14 USP/EP/BP
CBNumber: CB2363484
Molecular Formula: C81H114N20O18S2
Formula Weight: 1720.03
MOL File: 186901-48-4.mol

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CORTISTATIN-14 Property

Boiling point:: 2012.6±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: 1% acetic acid: 1mg/mL, clear, colorless
pka: 12.47±0.70(Predicted)
form: Solid
color: White to off-white
Sequence: {Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5808
Product name: Cortistatin 14
Purity: ≥97% (HPLC)
Packaging: 1vial
Price: $1590
Updated: 2025/07/31

Tocris

Product number: 3374
Product name: Cortistatin 14
Packaging: 1
Price: $249
Updated: 2021/12/16

Usbiological

Product number: 255031
Product name: Cortistatin 14
Packaging: 1mg
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0001160
Product name: CORTISTATIN 14, HUMAN, RAT
Purity: 95.00%
Packaging: 0.5MG
Price: $606.38
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0001160
Product name: CORTISTATIN 14, HUMAN, RAT
Purity: 95.00%
Packaging: 1MG
Price: $704.61
Updated: 2021/12/16

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CORTISTATIN-14 Chemical Properties,Usage,Production

Uses

Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).

Biological Activity

Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.', 'Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.

in vivo

Cortistatin-14 (10-250 μg/kg; injected in the footpad or intraperitoneal injection; six times a day) reduces acute neurogenic plasma protein leakage in the hind paw skin of rats caused by mustard oil, as well as carrageenan-induced paw edema in mice, mechanical hyperalgesia, the production of IL-1β and tumor necrosis factor-α, and mild heat injury-induced thermal hyperalgesia^[1].
Cortistatin-14 (10 μg; intravenous injection; single dose) plays a regulatory role in the pituitary secretion of male rats^[2].
Cortistatin-14 (1-10 nM, intracerebroventricular injection; single dose) has anticonvulsant and neuroprotective effects in rats by binding to somatostatin receptors, which leads to a reduction in the release of excitatory neurotransmitters^[3].

Animal Model:	Hydrochloride-induced rat^[3]
Dosage:	1 and 10 nM; single dose
Administration:	Intracerebroventricular injection (ICV)
Result:	Relieved epilepsy, inhibited neuronal loss, prevented the reduction of immune-active somatostatin and its receptors in the hippocampus, and reduced the release of 3H-D-aspartate under stimulation.

Animal Model:	Endotoxin-stimulated mice^[1]
Dosage:	10 μg/kg (i.p.); 100 μg/kg (i.p.); 250 μg/kg (i.pl.); six times a day
Administration:	Intraperitoneal injection (i.p.); i.pl.
Result:	Reduced the concentrations of TNF-α and IL-1β, reduced mustard oil-induced plasma protein extravasation in the dorsal skin, with an inhibition rate of nearly 80%, inhibited plantar thermal hyperalgesia in rats caused by mild thermal injury (51°C, 20 seconds).

Animal Model:	Wistar-Kyoto rat^[2]
Dosage:	10 μg; single dose
Administration:	Intravenous injection (i.v.)
Result:	Reduced growth hormone concentrations without affecting LH and FSH concentrations.

IC 50

SSTR1; SSTR2; SSTR3; SSTR4; SSTR5

CORTISTATIN-14 Preparation Products And Raw materials

Raw materials

Preparation Products

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CORTISTATIN-14 Suppliers

China 85 France 1 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 13 Global 106

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View Lastest Price from CORTISTATIN-14 manufacturers

Career Henan Chemical Co

Product: CORTISTATIN-14 186901-48-4
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

186901-48-4, CORTISTATIN-14Related Search:

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H-PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS-OH

CST-14

CST-14 (RAT)

CORTISTATIN (RAT)

CORTISTATIN-14

CORTISTATIN-14 (MOUSE, RAT)

CORTISTATIN (16-29)

(DES-ALA1,PRO2,SER12)-SOMATOSTATIN-14-LYS

PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS

CST-14, Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2-13]

Cortistatin 14, ≥97% (HPLC)

M.W. 1721.04 C81H113N19O19S2

PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS: PCKNFFWKTFSSCKDISULFIDE BRIDGE CYS2-CYS13

PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS(DISULFIDE BRIDGE:CYS2-CYS13)

Cortistatin-14 (Mouse, rat) (Des-Ala1,Pro2,Ser12)-SoMatostatin-14-Lys

Cortistatin14,Cortista

L-LysinaMide,L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-,cyclic (2&reg

13)-disulfide

Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]

Cortistatin 14, human, rat

2-L-Proline-14a-L-lysinamide-2-14-somatostatin (Petromyzon marinus)

L-Lysinamide, L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-, cyclic (2→13)-disulfide

Cortistatin-14(mouse)

CORTISTATIN-14 USP/EP/BP

CAS:186901-48-4

186901-48-4

C81H114N20O18S2

C81H113N19O19S2

Biochemicals and Reagents

BioChemical

Enzyme Inhibitors

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Enzymes, Inhibitors, and Substrates

Proteins

Peptide

Somatostatin receptor