CORTISTATIN-14
- Product Name
- CORTISTATIN-14
- CAS No.
- 186901-48-4
- Chemical Name
- CORTISTATIN-14
- Synonyms
- CST-14;CST-14 (RAT);13)-disulfide;CORTISTATIN-14;CAS:186901-48-4;CORTISTATIN (RAT);CORTISTATIN (16-29);Cortistatin-14(mouse);Cortistatin14,Cortista;CORTISTATIN-14 USP/EP/BP
- CBNumber
- CB2363484
- Molecular Formula
- C81H114N20O18S2
- Formula Weight
- 1720.03
- MOL File
- 186901-48-4.mol
CORTISTATIN-14 Property
- Boiling point:
- 2012.6±65.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- 1% acetic acid: 1mg/mL, clear, colorless
- pka
- 12.47±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- {Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C5808
- Product name
- Cortistatin 14
- Purity
- ≥97% (HPLC)
- Packaging
- 1vial
- Price
- $1590
- Updated
- 2025/07/31
- Product number
- 3374
- Product name
- Cortistatin 14
- Packaging
- 1
- Price
- $249
- Updated
- 2021/12/16
- Product number
- 255031
- Product name
- Cortistatin 14
- Packaging
- 1mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- PEP0001160
- Product name
- CORTISTATIN 14, HUMAN, RAT
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $606.38
- Updated
- 2021/12/16
- Product number
- PEP0001160
- Product name
- CORTISTATIN 14, HUMAN, RAT
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $704.61
- Updated
- 2021/12/16
CORTISTATIN-14 Chemical Properties,Usage,Production
Uses
Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).
Biological Activity
Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.', 'Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.
in vivo
Cortistatin-14 (10-250 μg/kg; injected in the footpad or intraperitoneal injection; six times a day) reduces acute neurogenic plasma protein leakage in the hind paw skin of rats caused by mustard oil, as well as carrageenan-induced paw edema in mice, mechanical hyperalgesia, the production of IL-1β and tumor necrosis factor-α, and mild heat injury-induced thermal hyperalgesia[1].
Cortistatin-14 (10 μg; intravenous injection; single dose) plays a regulatory role in the pituitary secretion of male rats[2].
Cortistatin-14 (1-10 nM, intracerebroventricular injection; single dose) has anticonvulsant and neuroprotective effects in rats by binding to somatostatin receptors, which leads to a reduction in the release of excitatory neurotransmitters[3].
| Animal Model: | Hydrochloride-induced rat[3] |
| Dosage: | 1 and 10 nM; single dose |
| Administration: | Intracerebroventricular injection (ICV) |
| Result: | Relieved epilepsy, inhibited neuronal loss, prevented the reduction of immune-active somatostatin and its receptors in the hippocampus, and reduced the release of 3H-D-aspartate under stimulation. |
| Animal Model: | Endotoxin-stimulated mice[1] |
| Dosage: | 10 μg/kg (i.p.); 100 μg/kg (i.p.); 250 μg/kg (i.pl.); six times a day |
| Administration: | Intraperitoneal injection (i.p.); i.pl. |
| Result: | Reduced the concentrations of TNF-α and IL-1β, reduced mustard oil-induced plasma protein extravasation in the dorsal skin, with an inhibition rate of nearly 80%, inhibited plantar thermal hyperalgesia in rats caused by mild thermal injury (51°C, 20 seconds). |
| Animal Model: | Wistar-Kyoto rat[2] |
| Dosage: | 10 μg; single dose |
| Administration: | Intravenous injection (i.v.) |
| Result: | Reduced growth hormone concentrations without affecting LH and FSH concentrations. |
IC 50
SSTR1; SSTR2; SSTR3; SSTR4; SSTR5
CORTISTATIN-14 Preparation Products And Raw materials
Raw materials
Preparation Products
CORTISTATIN-14 Suppliers
- Tel
- --
- Fax
- --
- neo@neomps.com
- Country
- France
- ProdList
- 2083
- Advantage
- 71
View Lastest Price from CORTISTATIN-14 manufacturers
- Product
- CORTISTATIN-14 186901-48-4
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24