ChemicalBook > CAS DataBase List > 2-Amino-4-methoxypyridine

2-Amino-4-methoxypyridine

Product Name
2-Amino-4-methoxypyridine
CAS No.
10201-73-7
Chemical Name
2-Amino-4-methoxypyridine
Synonyms
4-METHOXYPYRIDIN-2-AMINE;4-METHOXY-PYRIDIN-2-YLAMINE;KML-35;CML-032;4-Methoxypyridin-2-amin;4-Methoxy-2-pyridinamine;2-PyridinaMine,4-Methoxy;4-Methoxy-2-aMinopyridine;2-AMINO-4-METHOXYPYRIDINE;2-AMINO-4-METHOXYLPYRIDINE
CBNumber
CB2379186
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
10201-73-7.mol
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2-Amino-4-methoxypyridine Property

Melting point:
120-121°C
Boiling point:
258.6±20.0 °C(Predicted)
Density 
1.139±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO, Methanol
pka
7.79±0.11(Predicted)
form 
Solid
color 
Pale yellow
Water Solubility 
Soluble in Dimethyl sulfoxide, methanol. Slightly soluble in water.
Sensitive 
Air Sensitive
λmax
280nm(CHCl3)(lit.)
InChI
InChI=1S/C6H8N2O/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
InChIKey
QPHBCOSULYSASF-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC(OC)=C1
CAS DataBase Reference
10201-73-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HazardClass 
6.1
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
796956
Product name
4-Methoxypyridin-2-ylamine
Purity
95%
Packaging
1g
Price
$13.8
Updated
2022/05/15
TCI Chemical
Product number
A2690
Product name
2-Amino-4-methoxypyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$47
Updated
2025/07/31
TCI Chemical
Product number
A2690
Product name
2-Amino-4-methoxypyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$138
Updated
2025/07/31
TRC
Product number
A611995
Product name
2-Amino-4-methoxypyridine
Packaging
10g
Price
$210
Updated
2021/12/16
Usbiological
Product number
002332
Product name
2-Amino-4-methoxypyridine
Packaging
5g
Price
$460
Updated
2021/12/16
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2-Amino-4-methoxypyridine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

2-Amino-4-methoxypyridine is a highly selective inducible nitric oxide synthase inhibitors.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

19798-80-2

124-41-4

10201-73-7

General procedure for the synthesis of 2-amino-4-methoxypyridine from 2-amino-4-chloropyridine and sodium methanol: 4-chloropyridin-2-amine (10 g, 78.1 mmol) was dissolved in sodium methanol solution (50 mL, 1 M) in a sealed reaction tube. The reaction mixture was heated at 145 °C for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using 10% dichloromethane solution in methanol as eluent to give 7.7 g (79% yield) of 2-amino-4-methoxypyridine as an off-white solid. Mass spectrometry analysis (ESI): m/z = 125.04 [M + H]+, 281.75 [M/2 + H]+. LCMS retention time: tR = 0.17 min.

References

[1] Patent: WO2015/106292, 2015, A1. Location in patent: Paragraph 00592; 00603; 00604
[2] Journal of Organometallic Chemistry, 1996, vol. 523, # 2, p. 145 - 151
[3] Australian Journal of Chemistry, 1982, vol. 35, # 9, p. 1841 - 1849
[4] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2025 - 2034
[5] Patent: WO2012/151137, 2012, A1. Location in patent: Page/Page column 50-51

2-Amino-4-methoxypyridine Preparation Products And Raw materials

Raw materials

Sodium 2-Amino-4-chloropyridine Methanol

Preparation Products

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2-Amino-4-methoxypyridine Suppliers

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View Lastest Price from 2-Amino-4-methoxypyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-4-methoxypyridine 10201-73-7
Price
US $10.00-8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
R&D Scientific Inc.
Product
2-Amino-4-methoxy pyridine 10201-73-7
Price
US $980.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-03-27
Hebei Fengqiang Trading Co., LTD
Product
2-Amino-4-methoxypyridine 10201-73-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2023-06-13

10201-73-7, 2-Amino-4-methoxypyridineRelated Search:

4-Dimethylaminopyridine 6-Aminocaproic acid Glycine ALTRENOGEST 3-Amino-4-methylpyridine 3-Aminopyridine N-Ethylmethylamine Triethanolamine 2-Aminopyridine Triethylamine 4-Methoxypyridine 2,6-Diaminopyridine Bis(2-ethylhexyl)amine Dibenzylamine 4-Methylpyridin-2-amine 2-Aminophenol Tris(hydroxymethyl)aminomethane 4-Aminopyridine

  • 2-AMINO-4-METHOXYPYRIDINE
  • 4-METHOXYPYRIDIN-2-AMINE
  • 4-METHOXY-PYRIDIN-2-YLAMINE
  • 4-Methoxy-Pyridine-2-ylamine
  • 2-AMINO-4-METHOXYLPYRIDINE
  • 4-METHOXY-PYRIDIN-2-YLAMINE, 98.5%
  • 4-Methoxy-2-aMinopyridine
  • 4-(Methyloxy)-2-pyridinaMine
  • 2-PyridinaMine,4-Methoxy
  • 2-AMino-4-Methoxypyridine, 97+%
  • 4-Methoxy-2-pyridinamine
  • CML-032
  • 4-Methoxypyridin-2-amin
  • 4-Methoxypyridin-2-ylamine 95%
  • 2-Amino-4-methoxypyridine &gt
  • 2-Amino-4-methoxypyridine ISO 9001：2015 REACH
  • KML-35
  • N,N'-thiocarbonyldiimidazole
  • 10201-73-7
  • 10201-73-1
  • Heterocycle-Pyridine series
  • Pyridine
  • pharmacetical
  • Amines
  • Pyridines
  • Amines and Anilines
  • Heterocycles
  • intermediate