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PHENAMIL

Product Name
PHENAMIL
CAS No.
2038-35-9
Chemical Name
PHENAMIL
Synonyms
PHENAMIL;phenylamil;phenamil methanesulfonate salt;Phenamil methanesulfonate (free base);3,5-diamino-N-[amino(anilino)methylene]-6-chloro-pyrazinamide;3,5-DIAMINO-6-CHLORO-N-[IMINO(PHENYLAMINO)METHYL]-PYRAZINECAR-BOXAMIDE;3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine-2-carboxamide;3,5-diamino-N-[amino(anilino)methylidene]-6-chloropyrazine-2-carboxamide;2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-;3,5-bis(azanyl)-N-[azanyl-(phenylamino)methylidene]-6-chloro-pyrazine-2-carboxamide
CBNumber
CB2384179
Molecular Formula
C12H12ClN7O
Formula Weight
305.72
MOL File
2038-35-9.mol
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PHENAMIL Property

Melting point:
>181°C (dec.)
Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >15 mg/mL
form 
solid
pka
8.10±0.46(Predicted)
color 
yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
3379
Product name
Phenamil
Purity
≥99%(HPLC)
Packaging
50
Price
$353
Updated
2021/12/16
Usbiological
Product number
145690
Product name
Phenamil
Packaging
10mg
Price
$325
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008629
Product name
PHENAMIL
Purity
95.00%
Packaging
5MG
Price
$254.1
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008629
Product name
PHENAMIL
Purity
95.00%
Packaging
25MG
Price
$863.48
Updated
2021/12/16
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PHENAMIL Chemical Properties,Usage,Production

Uses

Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte

Definition

ChEBI: Phenylamil is a member of pyrazines and a member of guanidines.

Enzyme inhibitor

This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility.

PHENAMIL Preparation Products And Raw materials

Raw materials

Preparation Products

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PHENAMIL Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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info@efebio.com
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Jinan Yaoyan Pharmaceutical Co., Ltd.
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jnyaoyan@163.com
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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0519-85524369
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3477467573@qq.com
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TargetMol Chemicals Inc.
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2038-35-9, PHENAMILRelated Search:


  • PHENAMIL
  • 3,5-DIAMINO-6-CHLORO-N-[IMINO(PHENYLAMINO)METHYL]-PYRAZINECAR-BOXAMIDE
  • 3,5-diamino-6-chloro-n-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
  • phenamil methanesulfonate salt
  • phenylamil
  • 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine-2-carboxamide
  • 3,5-bis(azanyl)-N-[azanyl-(phenylamino)methylidene]-6-chloro-pyrazine-2-carboxamide
  • 3,5-diamino-N-[amino(anilino)methylene]-6-chloro-pyrazinamide
  • 3,5-diamino-N-[amino(anilino)methylidene]-6-chloropyrazine-2-carboxamide
  • Phenamil methanesulfonate (free base)
  • 2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-
  • 2038-35-9
  • C12H12ClN7OCH3SO3H
  • C12H12ClN7O
  • Irreversible inhibitor of amiloride-sensitive Na+ channels; derivative of amiloride.
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Amiloride and Derivatives
  • Monovalent Ion Channels
  • Ion Channels
  • Sodium Channel Modulators
  • Voltage-gated Ion Channels