ChemicalBook > CAS DataBase List > Aminoacetaldehyde dimethyl acetal

Aminoacetaldehyde dimethyl acetal

Product Name
Aminoacetaldehyde dimethyl acetal
CAS No.
22483-09-6
Chemical Name
Aminoacetaldehyde dimethyl acetal
Synonyms
AMINOACETALDEHYDE DIMETHYL ACETAL;2,2-Dimethoxyethanamine;AMINOACETOLDEHYDE DIMETHYL ACETOL;2,2-Dimethyethanamine;Aminoacetaldehyde dimethyl acetal ,98%;AMINOACETALDEHYDE DIMETHYL ACETAL (OR) 2,2- DIMETHOXYETHYLAMINE (ADMA);anjiahuanchun;DIMETHYLAMINOACETAL;Dimethoxyethylamine;Ammoniated methanol
CBNumber
CB2394455
Molecular Formula
C4H11NO2
Formula Weight
105.14
MOL File
22483-09-6.mol
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Aminoacetaldehyde dimethyl acetal Property

Melting point:
-78°C
Boiling point:
135-139 °C/95 mmHg (lit.)
Density 
0.965 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.417(lit.)
Flash point:
128 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
soluble in Chloroform, Methanol
pka
6.95±0.10(Predicted)
form 
Liquid
color 
Clear colorless to pale yellow
Water Solubility 
miscible
BRN 
741868
InChIKey
QKWWDTYDYOFRJL-UHFFFAOYSA-N
CAS DataBase Reference
22483-09-6(CAS DataBase Reference)
NIST Chemistry Reference
Aminoacetaldehyde dimethyl acetal(22483-09-6)
EPA Substance Registry System
Ethanamine, 2,2-dimethoxy- (22483-09-6)
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Safety

Hazard Codes 
C,F,Xi
Risk Statements 
10-34-36/37/38
Safety Statements 
26-36/37/39-45-16-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
2
Hazard Note 
Flammable/Corrosive
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
121967
Product name
Aminoacetaldehyde dimethyl acetal
Purity
99%
Packaging
25ml
Price
$66.5
Updated
2025/07/31
Sigma-Aldrich
Product number
121967
Product name
Aminoacetaldehyde dimethyl acetal
Purity
99%
Packaging
100ml
Price
$167.2
Updated
2025/07/31
TCI Chemical
Product number
A0801
Product name
Aminoacetaldehyde Dimethyl Acetal
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
A0801
Product name
Aminoacetaldehyde Dimethyl Acetal
Purity
>98.0%(GC)(T)
Packaging
250mL
Price
$275
Updated
2025/07/31
Sigma-Aldrich
Product number
121967
Product name
Aminoacetaldehyde dimethyl acetal
Purity
99%
Packaging
500ml
Price
$683
Updated
2025/07/31
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Aminoacetaldehyde dimethyl acetal Chemical Properties,Usage,Production

Description

Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.

Chemical Properties

clear colorless to pale yellow liquid

Uses

Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.

General Description

Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.

Synthesis

1) to disposable in container, add the ammonia soln that monochloroacetaldehyde dimethyl acetal and concentration are 10～40%, stir;
2) by step 1) in reaction solution stir, this reaction solution is warming up to 100～150 ℃;
3) by step 2) in reaction solution distill, reclaim ammoniacal liquor, until steam without obvious cut;
4) in step 3) in reaction solution in to add concentration be 20%～50% aqueous sodium hydroxide solution, regulate pH to 12～14;
5) by step 4) in solution carry out rectifying, collect colourless and light yellow transparent liquid, be target product aminoacetaldehyde dimethyl acetal.

Purification Methods

Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]

Aminoacetaldehyde dimethyl acetal Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate 6-Bromoisoquinoline ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate 6-(bromomethyl)isoquinoline 6-Methylisoquinoline 2-MERCAPTOIMIDAZOLE 8-METHYL-ISOQUINOLINE
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View Lastest Price from Aminoacetaldehyde dimethyl acetal manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
Aminoacetaldehyde dimethyl acetal 22483-09-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-09-04
Jinan Finer Chemical Co., Ltd
Product
2,2-Dimethoxyethylamine 22483-09-6
Price
US $0.00/KG
Min. Order
1KG
Purity
≥99%
Supply Ability
1000mt/year
Release date
2023-05-18
Asia Chem I and E (Jiangsu) Co Ltd
Product
Aminoacetaldehyde dimethyl acetal 22483-09-6
Price
US $39.10/Kg/Drum
Min. Order
200Kg/Drum
Purity
99.00%HPLC
Supply Ability
10tons/month
Release date
2021-11-09

22483-09-6, Aminoacetaldehyde dimethyl acetalRelated Search:

ETHANE 1,2-Dimethoxyethane Acetylacetaldehyde dimethyl acetal 4-Chlorobutanal dimethyl acetal Methylglyoxal 1,1-dimethyl acetal 2-METHOXYETHYLAMINE Bromoacetaldehyde diethyl acetal Bromoacetaldehyde dimethyl acetal Dimethyldimethoxysilane Dimethyl fumarate Dimethyl carbonate Dimethyl sulfoxide Chloroacetaldehyde diethyl acetal Chloroacetaldehyde dimethyl acetal Dacthal Triethylamine Dimethoxymethane Acetal

  • AMINOACETOLDEHYDE DIMETHYL ACETOL
  • 2,2-Dimetoxyethyl Amine
  • 2,2-Dimethoxyethylamin
  • Glycinal dimethyl acetal
  • Aminoacetaldehyd Dimethy Acetal
  • Aminoacetaldehyde dimethyl ace
  • anjiahuanchun
  • Aminoacetaldehyde dimethyl acetal ,98%
  • Aminoacetaldehyde dimethyl acetal,99%
  • Aminoacetaldehyde di
  • AMino acetaldehyde diMethyll acetal
  • AMinoacetaldehyde diMethyl acetal, 99% 100GR
  • AMinoacetaldehyde diMethyl acetal, 99% 25GR
  • AMINOACETALDEHYDE DIMETHYL ACETAL FOR SY
  • 2,2-Dimethoxyethylamine, 2-Amino-1,1-dimethoxyethane
  • AMinoacetaltwo Methanol
  • AMinoacetaldehyde DiMethyl Acetal, 97+%
  • AMino acetaldehyde condensation of Methanol
  • 2,2-Dimethyethanamine
  • 2,2-dimethoxy-ethanamin
  • 2,2-Dimethoxyethanamine
  • Acetaldehyde, amino-, dimethyl acetal
  • Ethanamine, 2,2-dimethoxy-
  • DIMETHYLAMINOACETAL
  • 2-AMINOACETALDEHYDE DIMETHYLACETAL
  • 1-AMINO-2,2-DIMETHOXYETHANE
  • 2,2-DIMETHOXYETHYLAMINE
  • AMINOACETALDEHYDE DIMETHYL ACETAL
  • 2-Methoxy-N-[2-methoxyethyl]-1-ethaneamine
  • 2-Aminoacetaldehyde dimethylacetal 98%
  • 2,2-DIMETHYLETHANAMINE
  • β,β-diethoxy-N,N-dimethylethylamine
  • Aminoacetaldehyde Dimethyl Acetal &gt
  • Dimethoxyethylamine
  • 2,2-Dimethoxyethylamine ISO 9001：2015 REACH
  • AMINOACETALDEHYDE DIMETHYL ACETAL (OR) 2,2- DIMETHOXYETHYLAMINE (ADMA)
  • 2,2-DIMETHOXY ETHYLAMINE(ADMA)
  • 2'2-Dimethoxyethylamine
  • Ammoniated methanol
  • 22483-09-6
  • 22483-09-06
  • 22483-09-5
  • 22483-09-4
  • 22843-09-6
  • H2NCH2CHOCH32
  • CH32NCH2CHOC2H52
  • NH2CH2CHOCH32
  • Aldehydes
  • Acetals/Ketals/Ortho Esters
  • Organic Building Blocks
  • Oxygen Compounds
  • Carbonyl Compounds
  • C1 to C6
  • Building Blocks
  • Pharmaceutical Intermediates
  • 1
  • 22483-09-6