MIBEFRADIL DIHYDROCHLORIDE

Product Name: MIBEFRADIL DIHYDROCHLORIDE
CAS No.: 116644-53-2
Chemical Name: MIBEFRADIL DIHYDROCHLORIDE
Synonyms: C07222;RO 40-5967;MIBEFRADIL DIHYDROCHLORIDE;(1S,2S)-2-[2-[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate;[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate;(1S,2S)-2-[2[[3-(2-BENZIMIDAZOLYLPROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-ISOPROPYL-2-NAPHTHYL METHOXYACETATE DIHYDROCHLORIDE;Methoxyacetic acid [[(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropylnaphthalen]-2-yl] ester;Acetic acid, methoxy-, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester;Acetic acid, Methoxy-, 2-[2-[[3-(1H-benziMidazol-2-yl)propyl]MethylaMino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-Methylethyl)-2-naphthalenylester, (1S-cis)-;(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylmethoxyacetoacetatedihydrochloride
CBNumber: CB2399511
Molecular Formula: C29H38FN3O3
Formula Weight: 495.63
MOL File: 116644-53-2.mol

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MIBEFRADIL DIHYDROCHLORIDE Property

Melting point:: 125 - 130°C
Boiling point:: 647.6±55.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 11.93±0.10(Predicted)
form: Solid
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 2198
Product name: Mibefradildihydrochloride
Purity: ≥97%(HPLC)
Packaging: 10
Price: $225
Updated: 2021/12/16

Tocris

Product number: 2198
Product name: Mibefradildihydrochloride
Purity: ≥97%(HPLC)
Packaging: 50
Price: $942
Updated: 2021/12/16

Usbiological

Product number: 255814
Product name: Mibefradil dihydrochloride
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ApexBio Technology

Product number: A3604
Product name: Mibefradil
Packaging: 50mg
Price: $621
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM65086
Product name: Mibefradil hydrochloride
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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MIBEFRADIL DIHYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Posicor,Roche Pharmaceuticals,USA

Uses

Mibefradil dihydrochloride is selectively blocks Ca2+?entry into cells by inhibiting T-type Ca2+?channels.

Uses

Vasodilator.

Definition

ChEBI: Mibefradil is a member of tetralins.

Manufacturing Process

To the solution of 5.35 g (28 mmol) [3-(1H-benzimidazol-2- yl)propyl]methylamine in 12.5 mL toluene was added by syringe 12.5 mL (11.42 g, 114 mmol) isopropenyl acetate. The reaction mixture was heated to reflux temperature, and stirred at that temperature for 1.75 hours, with reaction completion monitored by thin-layer chromatography (silica gel, eluting with 70% ethyl acetate/30% methanol). The product, N-[3-(1Hbenzimidazol-2-yl)propyl]-N-methylacetamide, was obtained in quantitative yield.
Under a dry nitrogen atmosphere, a 2.5 molar solution of butyl lithium in hexane, 8.4 mL (21 mmol) was added by syringe to 20 mL pentane. The solution was cooled to 0°C and 2.75 mL (2.13 g, 21 mmol) diisopropylamine was added by syringe over six min. The solution was warmed to 25°C and stirred for three hours, then volatiles were removed in vacuo. THF, 20 mL, was added via syringe to the residue, and the resulting yellow solution cooled to 0°C. A solution of 2.42 g (10.5 mmol) N-[3-(1H-benzimidazol-2-yl)propyl]- N-methylacetamide in 10 mL THF was added by syringe over 9 min. The yellow solution was stirred for 15 min, then cooled to -78°C. (S)-6-Fluoro-1- isopropyl-3,4-dihydro-1H-naphthalen-2-one, 2.166 g, 87.2% pure (97.6:2.4 S:R), in 2 mL toluene was added by syringe over 12 min, and a further 2 mL toluene was used to complete the transfer. After stirring for two hours, the viscous yellow mixture was added to 50 mL water at less than 10°C. The suspension that formed was extracted with diethyl ether; and the extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to afford 3.74 g of impure (1S,2S)-N-[3-(1H-benzimidazol-2-yl)propyl]- 2-(6-fluoro-2-hydroxy-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-
methylacetamide as a yellow foam. The foam was recrystallized from toluene, yield of a colorless solid 2.69 g, melting point 132-138°C. This material may be recrystallized a second time from toluene to remove residual (S)-6-fluoro- 1-isopropyl-3,4-dihydro-1H-naphthalen-2-one if necessary.
(1S,2S)-N-[3-(1H-Benzimidazol-2-yl)propyl]-2-(6-fluoro-2-hydroxy-1- isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylacetamidemay be synthesized by another method:
To the mixture 22.7 g (0.54 mol) dry lithium chloride and 100 mL THF at - 15°C was added 160 mL 2 molar lithium diisopropylamide (0.32 mol) in heptane/THF/ethylbenzene was added. Then a solution of 36.6 g (0.16 mol) N-[3-(1H-benzimidazol-2-yl)-propyl]-N-methylacetamide in 140 mL toluene was added, the solution was stirred for 2 hours, and a further 155 mL toluene was added. (S)-6-Fluoro-1-isopropyl-3,4-dihydro-1H-naphthalen-2-one (29.9 g, 0.15 mol), in 15 mL toluene was added. After stirring at -10°C for 4 hours, the resulting solution was added to 200 mL ice water. The pH of the resulting mixture was adjusted to 7-8 by addition of a 71 g concentrated hydrochloric acid. The organic layer washed with water, then the solvents removed under reduced pressure to give 96 g of (1S,2S)-N-[3-(1H-benzimidazol-2-yl)propyl]- 2-(6-fluoro-2-hydroxy-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl)-Nmethylacetamide as a brown oil. The product was crystallysed from toluene, yield 45.3 g.
(1S,2S)-N-[3-(1H-Benzimidazol-2-yl)propyl]-2-(6-fluoro-2-hydroxy-1- isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylacetamide,20.22 g (45.7 mmol), dissolved in 200 mL toluene at 40°C, was added by cannula over 40 min at 0°C to a suspension of sodium bis(2-methoxyethoxy)aluminum hydride in toluene, 40 mL (41.44 g suspension, 26.94 g sodium bis(2- methoxyethoxy)aluminum hydride, 133 mmol). The mixture was stirred at 0°C for 15 min, then at 35-40°C for 3 hours. The mixture was cooled to 25°C then added carefully to 70 g sodium hydroxide in 140 g ice. The resulting suspension was warmed to 25°C over 30 min, and the phases were separated. The aqueous phase was extracted with toluene; and the organic phase was washed twice with 10% aqueous sodium hydroxide, once with water, then once with saturated brine. The toluene phase was dried and concentrated in vacuo to afford 20.61 g of (1S,2S)-2-[2-{[3-(1H-benzimidazol-2- yl)propyl]methylmethylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4- tetrahydronaphthalen-2-ol as a colorless foam.
To the mixture of 41.0 g (1S,2S)-2-[2-{[3-(1H-benzimidazol-2- yl)propyl]methylmethylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4- tetrahydronaphthalen-2-ol, 240 mL water, and 240 mL toluene were added 22.4 g potassium hydroxide, and the mixture heated to 45-50°C for one hour. The resulting two-phase mixture was separated. To the organic phase was added 39.4 g (4.0 eq.) potassium carbonate sesquihydrate; then a solution of 21.0 g (17.7 mL, 3.25 eq.) methoxyacetyl chloride in 33 mL toluene was added over two hours at 25-30°C, and the resulting mixture stirred for an additional 30 min. Water, 200 mL, was added to quench the reaction. The organic phase, containing mibefradil as the free base was added an ethanol. To the stirred mixture of mibefradil and ethanol was added at 20°C a solution of 4.4 g of hydrogen chloride in 44.6 mL (35.0 g) ethanol. The mixture was heated to 50°C and 1.0 mL water was added, followed by a solution of 3.4 mL water in 332 mL methyl tert-butyl ether over one hour. The mixture was stirred for 3 hours. Mibefradil dihydrochloride crystals was seeded. A solution of 0.6 mL water in 65 mL methyl tert-butyl ether was added over one hour, and the mixture aged for a further 1.5 hours. The mixture was then cooled, and the resulting slurry of mibefradil dihydrochloride was filtered; yield 95%.

brand name

Posicor (Hoffmann-LaRoche).

Therapeutic Function

Coronary vasodilator

Biological Activity

Ca 2+ channel blocker with moderate selectivity for T-type Ca 2+ channels displaying IC 50 values of 2.7 μ M and 18.6 μ M for T-type and L-type channels respectively. Antihypertensive agent.

MIBEFRADIL DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MIBEFRADIL DIHYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Mibefradil 116644-53-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Mibefradil 116644-53-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

116644-53-2, MIBEFRADIL DIHYDROCHLORIDERelated Search:

CLONIDINE Mecamylamine hydrochloride Methyldopa Loperamide Carbenoxolone disodium Miglitol Amlodipine Lercanidipine Itraconazole Diltiazem MIBEFRADIL DIMETHYL PHENYL ETHYL CARBINYL ACETATE BETA PHENYL ETHYL METHYL ETHYL CARBINYL ACETATE Dimethylbenzylcarbinyl acetate 6-FLUORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-OL MIBEFRADIL DIHYDROCHLORIDE 3-(1H-IMIDAZOL-2-YL)PROPAN-1-AMINE 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL

C07222

(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylmethoxyacetoacetatedihydrochloride

Acetic acid, Methoxy-, 2-[2-[[3-(1H-benziMidazol-2-yl)propyl]MethylaMino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-Methylethyl)-2-naphthalenylester, (1S-cis)-

(1S,2S)-2-[2-[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate

(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL METHOXYACETOACETATE DIHYDROCHLORIDE

(1S,2S)-2-[2[[3-(2-BENZIMIDAZOLYLPROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-ISOPROPYL-2-NAPHTHYL METHOXYACETATE DIHYDROCHLORIDE

RO 40-5967

MIBEFRADIL DIHYDROCHLORIDE

Methoxyacetic acid [[(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropylnaphthalen]-2-yl] ester

[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate

Acetic acid, methoxy-, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester

116644-53-2

C29H38FN3O3