CYTOCHALASIN J
- Product Name
- CYTOCHALASIN J
- CAS No.
- 53760-20-6
- Chemical Name
- CYTOCHALASIN J
- Synonyms
- CYTOCHALASIN J;deacetylcytochalasin H;cytochalasin J from A phomopsis species;1H-Cycloundec[d]isoindol-1-one, 2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
- CBNumber
- CB2402529
- Molecular Formula
- C28H37NO4
- Formula Weight
- 451.6
- MOL File
- 53760-20-6.mol
CYTOCHALASIN J Property
- Melting point:
- 138°C (dec.)
- Boiling point:
- 679.5±55.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
- form
- white lyophilisate
- pka
- 13.03±0.70(Predicted)
- color
- White
- Stability:
- Light Sensitive
Safety
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-63-40
- Safety Statements
- 28-36/37-45-36/37/39-22
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- HA5306500
- F
- 10
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 18443
- Product name
- Cytochalasin J
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 18443
- Product name
- Cytochalasin J
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $401
- Updated
- 2024/03/01
- Product number
- C998718
- Product name
- CytochalasinJ
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- BVT-0450-M001
- Product name
- CytochalasinJ
- Purity
- ≥98%(NMR)
- Packaging
- 1mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- C4390
- Product name
- CytochalasinJ
- Packaging
- 1mg
- Price
- $117
- Updated
- 2021/12/16
CYTOCHALASIN J Chemical Properties,Usage,Production
Uses
Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.
Biological Activity
cytochalasin j can alter mitotic spindle microtubule organization and kinetochore structure.the cytochalasins are cell-permeable fungal metabolites inhibiting actin polymerization, which can alter diverse processes including cell movement, growth, phagocytosis, degranulation, and secretion.
in vitro
cytochalasin j was identified as a deacetylated analog of cytochalasin h that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure [1]. in a previous study, cytochalasin j treatment of prometaphase cells reduced the number of kmts and the size and organization of the kinetochore lamina. moreover, in approximately 30% of cells treated with cytochalasin j, the failure of a small number of chromosomes to attach to spindle fibers could be documented. these chromosomes showed a significant change in the organization of the kinetochore laminae. light microscopic analyses of cells treated with cytochalasin j revealed loss of chromosome congression, with chromsomes usually located at the periphery of the spindle. cells treated with 10 microg/ml cytochalasin j for 10 min and released into tissue culture medium showed a resumption of chromosome motion within a few minutes, both during congression and anaphase [2].
storage
+4°C
References
[1] walling, e. a.,krafft, g.a. and ware, b.r. actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. archives of biochemistry and biophysics 264(1), 321-332 (1988).
[2] wrench, g. a. and snyder, j.a. cytochalasin j treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in ptk1 cells. cell motility and the cytoskeleton 36(2), 112-124 (1997).
CYTOCHALASIN J Preparation Products And Raw materials
Raw materials
Preparation Products
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