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CYTOCHALASIN J

Product Name
CYTOCHALASIN J
CAS No.
53760-20-6
Chemical Name
CYTOCHALASIN J
Synonyms
CYTOCHALASIN J;deacetylcytochalasin H;cytochalasin J from A phomopsis species;1H-Cycloundec[d]isoindol-1-one, 2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
CBNumber
CB2402529
Molecular Formula
C28H37NO4
Formula Weight
451.6
MOL File
53760-20-6.mol
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CYTOCHALASIN J Property

Melting point:
138°C (dec.)
Boiling point:
679.5±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
form 
white lyophilisate
pka
13.03±0.70(Predicted)
color 
White
Stability:
Light Sensitive
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-63-40
Safety Statements 
28-36/37-45-36/37/39-22
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
HA5306500
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18443
Product name
Cytochalasin J
Purity
≥95%
Packaging
1mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
18443
Product name
Cytochalasin J
Purity
≥95%
Packaging
5mg
Price
$401
Updated
2024/03/01
TRC
Product number
C998718
Product name
CytochalasinJ
Packaging
2.5mg
Price
$165
Updated
2021/12/16
Adipogen Life Sciences
Product number
BVT-0450-M001
Product name
CytochalasinJ
Purity
≥98%(NMR)
Packaging
1mg
Price
$95
Updated
2021/12/16
ApexBio Technology
Product number
C4390
Product name
CytochalasinJ
Packaging
1mg
Price
$117
Updated
2021/12/16
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CYTOCHALASIN J Chemical Properties,Usage,Production

Uses

Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.

Biological Activity

cytochalasin j can alter mitotic spindle microtubule organization and kinetochore structure.the cytochalasins are cell-permeable fungal metabolites inhibiting actin polymerization, which can alter diverse processes including cell movement, growth, phagocytosis, degranulation, and secretion.

in vitro

cytochalasin j was identified as a deacetylated analog of cytochalasin h that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure [1]. in a previous study, cytochalasin j treatment of prometaphase cells reduced the number of kmts and the size and organization of the kinetochore lamina. moreover, in approximately 30% of cells treated with cytochalasin j, the failure of a small number of chromosomes to attach to spindle fibers could be documented. these chromosomes showed a significant change in the organization of the kinetochore laminae. light microscopic analyses of cells treated with cytochalasin j revealed loss of chromosome congression, with chromsomes usually located at the periphery of the spindle. cells treated with 10 microg/ml cytochalasin j for 10 min and released into tissue culture medium showed a resumption of chromosome motion within a few minutes, both during congression and anaphase [2].

storage

+4°C

References

[1] walling, e. a.,krafft, g.a. and ware, b.r. actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. archives of biochemistry and biophysics 264(1), 321-332 (1988).
[2] wrench, g. a. and snyder, j.a. cytochalasin j treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in ptk1 cells. cell motility and the cytoskeleton 36(2), 112-124 (1997).

CYTOCHALASIN J Preparation Products And Raw materials

Raw materials

Preparation Products

53760-20-6, CYTOCHALASIN JRelated Search:


  • CYTOCHALASIN J
  • cytochalasin J from A phomopsis species
  • deacetylcytochalasin H
  • 1H-Cycloundec[d]isoindol-1-one, 2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
  • 53760-20-6
  • Other
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Biochemicals and Reagents
  • BioChemical