Gabapentin-lactam
- Product Name
- Gabapentin-lactam
- CAS No.
- 64744-50-9
- Chemical Name
- Gabapentin-lactam
- Synonyms
- Gabapentin Related Compound A;3,3-PENTAMETHYLENE-4-BUTYROLACTAM;forgabapentine;Gabapentin RC A;Gabapentin-lactam;Gabapentin Lactum;Gabapentin USP RC A;Gabapentin EP Impurity A;Gabapentin impurity A CRS;3-AZASPIRO[4.5]DECAN-2-ONE
- CBNumber
- CB2415644
- Molecular Formula
- C9H15NO
- Formula Weight
- 153.22
- MOL File
- 64744-50-9.mol
Gabapentin-lactam Property
- Melting point:
- 84-89 °C(lit.)
- Boiling point:
- 181 °C / 13mmHg
- Density
- 1.05±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 40 mg/ml)
- pka
- 16.39±0.20(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChIKey
- JAWPQJDOQPSNIQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 64744-50-9(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- CM0120000
- HazardClass
- IRRITANT
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 553743
- Product name
- 4,4-Pentamethylene-2-pyrrolidinone
- Purity
- 96%
- Packaging
- 25g
- Price
- $209
- Updated
- 2024/03/01
- Product number
- 1287325
- Product name
- Gabapentin Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1380
- Updated
- 2024/03/01
- Product number
- P1695
- Product name
- 4,4-Pentamethylene-2-pyrrolidone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $39
- Updated
- 2024/03/01
- Product number
- P1695
- Product name
- 4,4-Pentamethylene-2-pyrrolidone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $114
- Updated
- 2024/03/01
- Product number
- Y0001281
- Product name
- Gabapentin impurity A
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001281
- Price
- $153
- Updated
- 2024/03/01
Gabapentin-lactam Chemical Properties,Usage,Production
Description
Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4
Chemical Properties
Gabapentin-lactam is White Solid
Uses
Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses
Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels
Definition
ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
References
1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845
Gabapentin-lactam Preparation Products And Raw materials
Raw materials
Preparation Products
Gabapentin-lactam Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from Gabapentin-lactam manufacturers
- Product
- Gabapentin-lactam 64744-50-9
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-17
- Product
- Gabapentin-lactam 64744-50-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Gabapentin-lactam 64744-50-9
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2019-12-20