ChemicalBook > CAS DataBase List > Gabapentin-lactam

Gabapentin-lactam

Product Name
Gabapentin-lactam
CAS No.
64744-50-9
Chemical Name
Gabapentin-lactam
Synonyms
Gabapentin Related Compound A;3,3-PENTAMETHYLENE-4-BUTYROLACTAM;forgabapentine;Gabapentin RC A;Gabapentin-lactam;Gabapentin Lactum;Gabapentin USP RC A;Gabapentin EP Impurity A;Gabapentin impurity A CRS;3-AZASPIRO[4.5]DECAN-2-ONE
CBNumber
CB2415644
Molecular Formula
C9H15NO
Formula Weight
153.22
MOL File
64744-50-9.mol
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Gabapentin-lactam Property

Melting point:
84-89 °C(lit.)
Boiling point:
181 °C / 13mmHg
Density 
1.05±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 40 mg/ml)
pka
16.39±0.20(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey
JAWPQJDOQPSNIQ-UHFFFAOYSA-N
CAS DataBase Reference
64744-50-9(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
CM0120000
HazardClass 
IRRITANT
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
553743
Product name
4,4-Pentamethylene-2-pyrrolidinone
Purity
96%
Packaging
25g
Price
$209
Updated
2024/03/01
Sigma-Aldrich
Product number
1287325
Product name
Gabapentin Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
P1695
Product name
4,4-Pentamethylene-2-pyrrolidone
Purity
>98.0%(GC)
Packaging
5g
Price
$39
Updated
2024/03/01
TCI Chemical
Product number
P1695
Product name
4,4-Pentamethylene-2-pyrrolidone
Purity
>98.0%(GC)
Packaging
25g
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001281
Product name
Gabapentin impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001281
Price
$153
Updated
2024/03/01
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Gabapentin-lactam Chemical Properties,Usage,Production

Description

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4

Chemical Properties

Gabapentin-lactam is White Solid

Uses

Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels

Definition

ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

References

1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845

Gabapentin-lactam Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Gabapentin-lactam manufacturers

Hebei Duling International Trade Co. LTD
Product
Trimethyl phosphonoacetate 64744-50-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000
Release date
2023-01-07
Hebei Zhanyao Biotechnology Co. Ltd
Product
Gabapentin-lactam 64744-50-9
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
Gabapentin-lactam 64744-50-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

64744-50-9, Gabapentin-lactamRelated Search:

Gabapentin 1,2-PENTADIENE Cyclopentene Dipentene Dicyclopentadiene 1,3-Cyclopentadiene METHYLCYCLOPENTADIENE DIMER TRANS-1,3-PENTADIENE 2,2-DI-N-PROPYLACETAMIDE Decane Gabapentin Related Compound E 1-Cyanocyclohexaneacetic acid Cyclopentane Glutarimide 3,3-Pentamethylene glutarimide 2-Pyrrolidinone 3,3-DIETHYLPYRROLIDINE 4,4-dimethyl-2-pyrrolidinone

  • 2-AZA-SPIRO[4.5]DECAN-3-ONE
  • Gabapentin-lactam
  • 3-AZASPIRO[4.5]DECAN-2-ONE
  • 4,4-PENTAMETHYLENE-2-PYRROLIDINONE
  • 3,3'-PENTAMETHYLENE-4-BUTYROLACTAM
  • 3,3-PENTAMETHYLENE-4-BUTYROLACTAM
  • beta,beta-pentamethylen-gamma-butyrolactam
  • 3,3-Pentamethylene glutarimide (CDI) or 2-Azaspiro{4,5} decan-3-one
  • 3,3-PENTAMETHYLENE-4-BUTYROLACTAM(CDI) 98.0+%
  • 3,3-Pentamethylene-4-butyrolactame2-Azaspiro[4.5]decan-3-one
  • forgabapentine
  • 3-Azaspiro-[4,5]decan-3-one
  • Gabapentin Related Compound A
  • 3,3-Pentamethylene-4-butyrolac
  • 4,4-pentamethylene-2-pyrrolidone
  • 3,3-Pentenylene-4-butyrolactam
  • 3,3-Pentamethylene glutarimide (CDI)
  • 3,3-Pentamethylene-4-butyrolactam(Gabalactam)(CDI)
  • 3,3-Pentamethylene- 4- Butyrolactam DI
  • 1-(Aminomethyl)cyclohexane-1-acetic acid-lactam
  • Gabapentin USP RC A
  • Pentamethylene pyrrolidinone
  • Gabapentin Related Compound A (50 mg) (3,3-pentamethylene-5-butyrolactam)
  • Gabapentin Related CoMpound A, USP
  • Gabapentin Impurit Ⅰ:2-Azaspiro-[4,5]decan-3-one( Gabapentin EP Impurity A)
  • 2-(1-oxo-3,4,5,6,7,7a-hexahydro-2H-isoindol-3a-yl)acetic acid
  • Gabapentin impurity A
  • Gabapentin Related Compound A (50 mg) (2-Azaspiro[4.5]decan-3-one)
  • Gabapentin EP Impurity A
  • 4,4-Pentamethylene-2-pyrrolidinone 96%
  • 2-PYRROLIDONE,4,4-PENTAMETHYLENE
  • Gabapentin impurity A (EP)
  • 3,3-Pentamethylene-5-butyrolactam
  • Gabapentin Impurity 1(Gabapentin EP Impurity A)
  • beta,beta-Pentamethylen-gamma-butyrolactam [German]
  • Gabapentin impurity A CRS
  • 4,4-Pentamethylene-2-pyrrolidone&gt
  • 3, 3-cyclopentane-4-butanolactam
  • Gabapentin RC A
  • Gabapentin EP Impurity A/ Gabapentin Related Compound A (Gabapentin Lactam)
  • Gabapentin impurity A (Y0001281)
  • Gabapentin Related Compound AQ: What is Gabapentin Related Compound A Q: What is the CAS Number of Gabapentin Related Compound A Q: What is the storage condition of Gabapentin Related Compound A Q: What are the applications of Gabapentin Related Compound A
  • Gabapentin Impurit Ⅰ:2-Azaspiro-[4,5]decan-3-one( Gabapentin EP Impurity A)
  • Gabapentin Related Compound A (2-Azaspiro[4.5]decan-3-one) (1287325)
  • 2-Azaspiro[4.5]decan-3-one (3,3-Pentamethylene-4-butyrolactam)
  • Gabapentin USP Related Compound A
  • 2-Azaspiro[4.5]decan-3-one (6CI, 9CI, ACI)
  • Gabapentin EP Impurity A Gabapentin USP Related Compound A
  • Gabapentin Lactum
  • 64744-50-9
  • 4744-50-9
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrrolidines
  • Building Blocks
  • C4 to C10
  • Chemical Synthesis
  • Heterocyclic Building Blocks