Gabapentin-lactam

Product Name: Gabapentin-lactam
CAS No.: 64744-50-9
Chemical Name: Gabapentin-lactam
Synonyms: Gabapentin Related Compound A;3,3-PENTAMETHYLENE-4-BUTYROLACTAM;forgabapentine;Gabapentin RC A;Gabapentin-lactam;Gabapentin Lactum;Gabapentin USP RC A;Gabapentin EP Impurity A;Gabapentin impurity A CRS;3-AZASPIRO[4.5]DECAN-2-ONE
CBNumber: CB2415644
Molecular Formula: C9H15NO
Formula Weight: 153.22
MOL File: 64744-50-9.mol

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Gabapentin-lactam Property

Melting point:: 84-89 °C(lit.)
Boiling point:: 181 °C / 13mmHg
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 40 mg/ml)
pka: 16.39±0.20(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey: JAWPQJDOQPSNIQ-UHFFFAOYSA-N
CAS DataBase Reference: 64744-50-9(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: CM0120000
HazardClass: IRRITANT
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 553743
Product name: 4,4-Pentamethylene-2-pyrrolidinone
Purity: 96%
Packaging: 25g
Price: $209
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1287325
Product name: Gabapentin Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $1380
Updated: 2024/03/01

TCI Chemical

Product number: P1695
Product name: 4,4-Pentamethylene-2-pyrrolidone
Purity: >98.0%(GC)
Packaging: 5g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: P1695
Product name: 4,4-Pentamethylene-2-pyrrolidone
Purity: >98.0%(GC)
Packaging: 25g
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001281
Product name: Gabapentin impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001281
Price: $153
Updated: 2024/03/01

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Gabapentin-lactam Chemical Properties,Usage,Production

Description

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4

Chemical Properties

Gabapentin-lactam is White Solid

Uses

Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels

Definition

ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

References

1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845

Gabapentin-lactam Preparation Products And Raw materials

Raw materials

Preparation Products

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Gabapentin-lactam Suppliers

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View Lastest Price from Gabapentin-lactam manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: Gabapentin-lactam 64744-50-9
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gabapentin-lactam 64744-50-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Gabapentin-lactam 64744-50-9
Price: US $1.00/KG
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2019-12-20

64744-50-9, Gabapentin-lactamRelated Search:

Gabapentin 1,2-PENTADIENE Cyclopentene Dipentene Dicyclopentadiene 1,3-Cyclopentadiene METHYLCYCLOPENTADIENE DIMER TRANS-1,3-PENTADIENE 2,2-DI-N-PROPYLACETAMIDE Decane Gabapentin Related Compound E 1-Cyanocyclohexaneacetic acid Cyclopentane Glutarimide 3,3-Pentamethylene glutarimide 2-Pyrrolidinone 3,3-DIETHYLPYRROLIDINE 4,4-dimethyl-2-pyrrolidinone

2-AZA-SPIRO[4.5]DECAN-3-ONE

Gabapentin-lactam

3-AZASPIRO[4.5]DECAN-2-ONE

4,4-PENTAMETHYLENE-2-PYRROLIDINONE

3,3'-PENTAMETHYLENE-4-BUTYROLACTAM

3,3-PENTAMETHYLENE-4-BUTYROLACTAM

beta,beta-pentamethylen-gamma-butyrolactam

3,3-Pentamethylene glutarimide (CDI) or 2-Azaspiro{4,5} decan-3-one

3,3-PENTAMETHYLENE-4-BUTYROLACTAM(CDI) 98.0+%

3,3-Pentamethylene-4-butyrolactame2-Azaspiro[4.5]decan-3-one

forgabapentine

3-Azaspiro-[4,5]decan-3-one

Gabapentin Related Compound A

3,3-Pentamethylene-4-butyrolac

4,4-pentamethylene-2-pyrrolidone

3,3-Pentenylene-4-butyrolactam

3,3-Pentamethylene glutarimide (CDI)

3,3-Pentamethylene-4-butyrolactam(Gabalactam)(CDI)

3,3-Pentamethylene- 4- Butyrolactam DI

1-(Aminomethyl)cyclohexane-1-acetic acid-lactam

Gabapentin USP RC A

Pentamethylene pyrrolidinone

Gabapentin Related Compound A (50 mg) (3,3-pentamethylene-5-butyrolactam)

Gabapentin Related CoMpound A, USP

Gabapentin Impurit Ⅰ:2-Azaspiro-[4,5]decan-3-one( Gabapentin EP Impurity A)

2-(1-oxo-3,4,5,6,7,7a-hexahydro-2H-isoindol-3a-yl)acetic acid

Gabapentin impurity A

Gabapentin Related Compound A (50 mg) (2-Azaspiro[4.5]decan-3-one)

Gabapentin EP Impurity A

4,4-Pentamethylene-2-pyrrolidinone 96%

2-PYRROLIDONE,4,4-PENTAMETHYLENE

Gabapentin impurity A (EP)

3,3-Pentamethylene-5-butyrolactam

Gabapentin Impurity 1(Gabapentin EP Impurity A)

beta,beta-Pentamethylen-gamma-butyrolactam [German]

Gabapentin impurity A CRS

4,4-Pentamethylene-2-pyrrolidone&gt

3, 3-cyclopentane-4-butanolactam

Gabapentin RC A

Gabapentin EP Impurity A/ Gabapentin Related Compound A (Gabapentin Lactam)

Gabapentin impurity A (Y0001281)

Gabapentin Related Compound AQ: What is Gabapentin Related Compound A Q: What is the CAS Number of Gabapentin Related Compound A Q: What is the storage condition of Gabapentin Related Compound A Q: What are the applications of Gabapentin Related Compound A

Gabapentin Impurit Ⅰ:2-Azaspiro-[4,5]decan-3-one( Gabapentin EP Impurity A)

Gabapentin Related Compound A (2-Azaspiro[4.5]decan-3-one) (1287325)

2-Azaspiro[4.5]decan-3-one (3,3-Pentamethylene-4-butyrolactam)

Gabapentin USP Related Compound A

2-Azaspiro[4.5]decan-3-one (6CI, 9CI, ACI)

Gabapentin Lactum

Gabapentin EP Impurity A Gabapentin USP Related Compound A

64744-50-9

4744-50-9

Building Blocks

Heterocyclic Building Blocks

Pyrrolidines

Building Blocks

C4 to C10

Chemical Synthesis

Heterocyclic Building Blocks