ChemicalBook > CAS DataBase List > Nefiracetam

Nefiracetam

Product Name
Nefiracetam
CAS No.
77191-36-7
Chemical Name
Nefiracetam
Synonyms
DMMPA;dmppa;dm9384;DZL-221;Translon;NEFIRACETAM;Nefiracetam>Nefiracetam powder;Nefiracetam (DM9384;Racetam Nefiracetam
CBNumber
CB2416333
Molecular Formula
C14H18N2O2
Formula Weight
246.3
MOL File
77191-36-7.mol
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Nefiracetam Property

Melting point:
151-155°C
Boiling point:
458.5±33.0 °C(Predicted)
Density 
1.187±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: >5mg/mL
pka
13.77±0.70(Predicted)
form 
solid
color 
white to off-white
Merck 
14,6439
InChI
InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChIKey
NGHTXZCKLWZPGK-UHFFFAOYSA-N
SMILES
N1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O
CAS DataBase Reference
77191-36-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
UX9655650
HS Code 
2933.79.1500
Toxicity
LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N2288
Product name
Nefiracetam
Purity
solid
Packaging
50mg
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
N2288
Product name
Nefiracetam
Purity
solid
Packaging
250mg
Price
$738
Updated
2024/03/01
TCI Chemical
Product number
N0996
Product name
Nefiracetam
Purity
>98.0%(N)
Packaging
200mg
Price
$125
Updated
2024/03/01
TCI Chemical
Product number
N0996
Product name
Nefiracetam
Purity
>98.0%(N)
Packaging
1g
Price
$497
Updated
2024/03/01
Tocris
Product number
2851
Product name
Nefiracetam
Purity
≥99%(HPLC)
Packaging
100
Price
$156
Updated
2021/12/16
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Nefiracetam Chemical Properties,Usage,Production

Uses

analgesic, antiinflammatory

Uses

Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.

Definition

ChEBI: Nefiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

Biological Activity

Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .

Mechanism of action

The mechanisms of nefiracetam seem to be linked back to two pathways. One of these pathways prolongs the opening of calcium channels (tied into PKA and a Gi/o protein), which enhances the signalling of a receptor independent of the synapse. The other pathway seems to be tied into PKC and CAMKII, which then augments signalling through cholinergic receptors (which then releases most excitatory neurotransmitters from the presynaptic level, like nicotine). The former pathway (calcium channels) appears critical for long-term potentiation, whereas the latter pathway (PKC/CAMKII) appears vital for neuronal signal enhancement. Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.

storage

Store at RT

Nefiracetam Preparation Products And Raw materials

Raw materials

Pyrrolidone 2,6-Dimethylaniline

Preparation Products

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Nefiracetam Suppliers

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View Lastest Price from Nefiracetam manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Nefiracetam 77191-36-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-03-01
hebei hongtan Biotechnology Co., Ltd
Product
Nefiracetam 77191-36-7
Price
US $80.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
500
Release date
2024-03-20
Jinan Jianfeng Chemical Co., Ltd
Product
Nefiracetam 77191-36-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20ton
Release date
2024-08-13

77191-36-7, NefiracetamRelated Search:

N,N-Dimethylacetamide Citalopram Gabapentin Pramiracetam Aniracetam Oxiracetam Nefiracetam N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Pyrrolidine Piracetam Pyrrocaine Lidocaine Pyrrole MONOETHYLGLYCINEXYLIDIDE 1-(2-aminoethyl)pyrrolidin-2-one N-(2-METHYLPHENYL)-2-(PROPYLAMINO)ACETAMIDE 1-[2-OXO-2-(4,4,6-TRIMETHYL-1-THIOXO-1,4-DIHYDRO-5H-[1,2]DITHIOLO[3,4-C]QUINOLIN-5-YL)ETHYL]PYRROLIDINE-2,5-DIONE

  • n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
  • NEFIRACETAM
  • 2-oxo-1-pyrrolidinylaceticacid,2,6-dimethylanilide
  • dm9384
  • dmppa
  • n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid
  • DM-9384, (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)
  • DMMPA
  • DZL-221
  • Translon
  • 2',6'-Dimethyl-2-(2-oxo-1-pyrrolidinyl)acetoanilide
  • N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
  • (2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)
  • NefiracetaM(Translon)
  • 1-PyrrolidineacetaMide,N-(2,6-diMethylphenyl)-2-oxo-
  • N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide
  • Nefiracetam powder
  • Nefiracetam/C14H18N2O2
  • Nefiracetam&gt
  • Nefiracetam USP/EP/BP
  • Nefiracetam (DM9384
  • Racetam Nefiracetam
  • TIANFU-CHEM_ Nefiracetam
  • Nai the west temple
  • Nefiracetam in methanol
  • Nefiracetam, 10 mM in DMSO
  • 77191-36-7
  • 77161-36-7
  • Pharmaceutical intermediate
  • TRANSLON
  • Nootropic
  • Smart drug
  • BDO
  • API