Ethyl 4-chloroacetoacetate

Product Name: Ethyl 4-chloroacetoacetate
CAS No.: 638-07-3
Chemical Name: Ethyl 4-chloroacetoacetate
Synonyms: ETHYL 4-CHLORO-3-OXOBUTANOATE;Ethyl 4-chloro-3-oxobutyrate;oroacetoacetate;AKOS BBS-00004336;Ethyl 4-chloroacetoa;4-Chloro-acetoacetic;Amlodipine Impurity R;Amlodipine Impurity 66;Oxiracetam Impurity 15;Ethyl-4-chloracetoacetat
CBNumber: CB2424408
Molecular Formula: C6H9ClO3
Formula Weight: 164.59
MOL File: 638-07-3.mol

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Ethyl 4-chloroacetoacetate Property

Melting point:: -8 °C
Boiling point:: 115 °C/14 mmHg (lit.)
Density: 1.218 g/mL at 25 °C (lit.)
vapor pressure: 7hPa at 20℃
refractive index: n20/D 1.452(lit.)
Flash point:: 206 °F
storage temp.: 2-8°C
solubility: 47.0g/l
form: Liquid
pka: 9.56±0.46(Predicted)
color: Clear colorless to pale reddish-yellow
PH: 2.9 (10g/l, H2O, 20℃)
explosive limit: 1.8%(V)
Water Solubility: 47.5 g/L (20 ºC)
BRN: 1761275
InChIKey: OHLRLMWUFVDREV-UHFFFAOYSA-N
LogP: 0.68 at 25℃
CAS DataBase Reference: 638-07-3(CAS DataBase Reference)
NIST Chemistry Reference: Butanoic acid, 4-chloro-3-oxo-, ethyl ester(638-07-3)
EPA Substance Registry System: Ethyl 4-chloroacetoacetate (638-07-3)

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Safety

Hazard Codes: T,N,C
Risk Statements: 25-34-51/53-24/25-36
Safety Statements: 26-36-45-61-36/37/39-27
RIDADR: UN 2922 8/PG 2
WGK Germany: 3
RTECS: AK5110000
F: 8-10-19-21
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29183000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 180769
Product name: Ethyl 4-chloroacetoacetate
Purity: 95%
Packaging: 50g
Price: $57.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 180769
Product name: Ethyl 4-chloroacetoacetate
Purity: 95%
Packaging: 250g
Price: $117
Updated: 2024/03/01

TCI Chemical

Product number: C0911
Product name: Ethyl 4-Chloroacetoacetate
Purity: >95.0%(GC)
Packaging: 25g
Price: $19
Updated: 2024/03/01

TCI Chemical

Product number: C0911
Product name: Ethyl 4-Chloroacetoacetate
Purity: >95.0%(GC)
Packaging: 500g
Price: $160
Updated: 2024/03/01

Alfa Aesar

Product number: A15641
Product name: Ethyl 4-chloroacetoacetate, 97%
Packaging: 50g
Price: $32.65
Updated: 2024/03/01

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Ethyl 4-chloroacetoacetate Chemical Properties,Usage,Production

Chemical Properties

Ethyl 4-chloroacetoacetate is colorless to pale reddish-yellow clear liquid

Uses

Ethyl-4-chloracetoacetate (CAAEt) is used as intermediate for organic syntheses, e.g. ethyl 4-chloro-3-arylaminocrotonates, diethyl succinylsuccinate, 2-alkyl-4-hydroxy-6-chloromethylpyrimidines, 4- chloromethylcoumarines. Product Data Sheet

Uses

Ethyl 4-chloroacetoacetate is used as a precursor in the preparation of phosphorous ylides. It finds application in regular film coating, pharmaceutical coating and formulation.

Preparation

Preparative Methods of Ethyl 4-chloroacetoacetate: the industrial production of the esters is made exclusively by chlorination of diketene followed by reaction of the intermediate acid chloride with the corresponding alcohol.^[2]

Solubility in organics

Ethyl 4-Chloroacetoacetate is is soluble in most organic solvents. The ethyl ester (1a) is 12% enolized in the pure liquid, and highly enolized (60% in CCl4) in nonpolar solvents.^[1]

storage

Ethyl 4-chloroacetoacetate is lachrymators of moderate toxicity; uses in a fume hood.

References

1. Rappoport, Z. The Chemistry of Enols; Wiley: New York, 1990; p 365.
2. Lonza AG; U.S. Patent 4 473 508, 1984 (CA 1985, 102, 5715).

Ethyl 4-chloroacetoacetate Preparation Products And Raw materials

Raw materials

Acetyl ketene Ethanol Chlorine METHANE

Preparation Products

4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE 4-CHLOROMETHYL-6-METHYL-CHROMEN-2-ONE 2-(6-METHOXY-1-BENZOFURAN-3-YL)ACETIC ACID

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View Lastest Price from Ethyl 4-chloroacetoacetate manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Ethyl 4-chloroacetoacetate 638-07-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-22

Qingdao RENAS Polymer Material Co., Ltd.

Product: 4-Chloroacetoacetic acid ethyl ester 638-07-3
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-08-26

airuikechemical co., ltd.

Product: Ethyl 4-Chloroacetoacetate 638-07-3
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

638-07-3, Ethyl 4-chloroacetoacetateRelated Search:

Ethyl acrylate Ethyl 4,4,4-trifluoroacetoacetate Ethyl acetoacetate Ethyl cyanoacetate Ethylparaben Ethanol Ethyl 2-methylacetoacetate Ethyl 4-bromoacetoacetate Ethyl chloroacetate ISOXADIFEN-ETHYL Trinexapac-ethyl Ethyl propiolate Ethyl acetate 2-Hexenoic acid, 4,5-dihydroxy-, (2E,4S,5R)- 2-Hexenoic acid, 4,5-dihydroxy- 1-Butanaminium, 4-methoxy-N,N,N-trimethyl-2,4-dioxo-, chloride (1:1) 4-CHLORO-3-ETHOXY-BUT-2-ENOIC ACID ETHYL ESTER Ethyl2-chloroacetoacetate,97%,ETHYL 2-CHLOROACETOACETATE,ETHYL ALPHA-CHLOROACETOACETATE,ETHYL 2-CHLOROACETOACETATE, WACKERQUALIT Y

AKOS BBS-00004336

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4-chloro-3-oxo-butanoicaciethylester

4-chloro-acetoaceticaciethylester

4-Chloroacetoacetic Acid Ethyl Ester Ethyl (Chloroacetyl)acetate (Chloroacetyl)acetic Acid Ethyl Ester Ethyl 4-Chloro-3-oxobutyrate 4-Chloro-3-oxobutyric Acid Ethyl Ester

Ethyl 4-chloroacetoa

Ethyl 4-chloroacetoacetate 95%

Ethyl 4-chloroacetoacetate, 99%+

4 - chlorine ethyl acetoacetate

Acetoacetic acid, 4-chloro-, ethyl ester

Ethyl4-chloroacetoacetate,97%

4-Chloro-acetoacetic

Ethyl-4-chloracetoacetat

4-chloro-3-oxo-butanoic acid ethyl ester

4-CHLOROACETOACETIC ACID ETHYL ESTER 95%

Ethyl 4-chloro-3-oxobutyrate

Ethyl (chloroacetyl)acetate

Ethyl g-chloroacetoacetate

Ethyl 4-chloroacetoacetate ,98%

(Chloroacetyl)acetic acid ethyl ester

3-Oxo-4-chlorobutanoic acid ethyl

3-Oxo-4-chlorobutanoic acid ethyl ester

4-Chloro-3-oxobutyric acid ethyl ester

Ethyl-4chloroacetaacetate

Ethyl 4-chloroacetoacetate 95%/99%

Ethyl 4-chloroacetoacetate, 98% 250GR

Ethyl 4-chloroacetoacetate, 98% 50GR

Ethyl-4-chIoroaoetoacetate

Oxiracetam Impurity 15

Amlodipine Impurity R

oroacetoacetate

Ethyl 4-Chloroacetoacetate &gt

Levocabastine Impurity 6

4-Chloroacetoacetate ethyl ester

4-Chloracetoacetic acid ethyl ester

4-Chloroacetyl Ethyl Acetate

638-07-3

ClCH2COCH2CO2C2H5

KETONE

Building Blocks

Carbonyl Compounds

C6 to C7

Esters

Organic Building Blocks

C6 to C7

Carbonyl Compounds

Esters

Aliphatics

Pharmaceutical Intermediates

Halogen compounds

1

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