C8 CERAMIDE
- Product Name
- C8 CERAMIDE
- CAS No.
- 74713-59-0
- Chemical Name
- C8 CERAMIDE
- Synonyms
- C8 CERAMIDE;CERAMIDE C8;08:0 CERAMIDE;N-Octanoyl-D-erythr;N-OCTANOYLSPHINGOSINE;C8-D-ERYTHRO-CERAMIDE;C8 CERAMINE, D-ERYTHRO;N-Octanoyl-D-erythro-sp;C8 Ceramide (d18:1/8:0);N-OCTANOYL-D-SPHINGOSINE
- CBNumber
- CB2432038
- Molecular Formula
- C26H51NO3
- Formula Weight
- 425.69
- MOL File
- 74713-59-0.mol
C8 CERAMIDE Property
- Melting point:
- 68-70°C
- Boiling point:
- 541.37°C (rough estimate)
- Density
- 0.9974 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- −20°C
- solubility
- DMSO or ethanol: soluble
- form
- waxy solid
- color
- White
- Stability:
- Temperature Sensitive
- InChIKey
- APDLCSPGWPLYEQ-WRBRXSDHSA-N
- SMILES
- C(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)(=O)CCCCCCC
- CAS DataBase Reference
- 74713-59-0(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29225000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 62540
- Product name
- C-8 Ceramide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $20
- Updated
- 2024/03/01
- Product number
- 62540
- Product name
- C-8 Ceramide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $69
- Updated
- 2024/03/01
- Product number
- 62540
- Product name
- C-8 Ceramide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- 62540
- Product name
- C-8 Ceramide
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $219
- Updated
- 2024/03/01
- Product number
- C265513
- Product name
- C-8Ceramide
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
C8 CERAMIDE Chemical Properties,Usage,Production
Description
C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4
Chemical Properties
Off White Powder
Uses
A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis
Uses
C-8 Ceramide is a ceramide analog.
Definition
ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid.
in vivo
C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice[3].
| Animal Model: | C57BL/6 mice, with lymphocytic choriomeningitis virus infected[3] |
| Dosage: | 0.1 mg/kg |
| Administration: | Intranasal administration |
| Result: | Increased the CD8+ T cell response to influenza in the lungs. |
IC 50
PKC; apoptosis; autophagy
References
[1] S MATHIAS R N K K A Dressler. Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88 22: 10009-10013. DOI:10.1073/pnas.88.22.10009
[2] W D JARVIS. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 1: 73-77. DOI:10.1073/pnas.91.1.73
[3] BRAD L UPHAM . Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis[J]. Cancer letters, 2003, 191 1: Pages 27-34. DOI:10.1016/s0304-3835(02)00620-1
[4] KAZUYUKI NAKAJIMA. Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro[J]. Journal of Neurochemistry, 2002, 80 4: 697-705. DOI:10.1046/j.0022-3042.2001.00752.x
C8 CERAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
C8 CERAMIDE Suppliers
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View Lastest Price from C8 CERAMIDE manufacturers
- Product
- C8 CERAMIDE 74713-59-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-20