ChemicalBook > CAS DataBase List > (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER

(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER

Product Name
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
CAS No.
160706-62-7
Chemical Name
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
Synonyms
D-1-CBZ-NIPECOTIC ACID;(R)-1-Benzyloxycarbonylnipecotic acid;(R)-1-CBZ-3-piperidinecarboxylic acid;(R)-1-CBZ-PIPERIDINE-3-CARBOXYLIC ACID;1-Cbz-(3R)-3-piperidinecarboxylic acid;(R)-1-CBZ-PIPERIDINE-1-CARBOXYLIC ACID;(R)-(+)-N-cbz-3-piperidinecarboxylic acid;3(R)-N-(Carbobenzyloxy)-3-carboxypiperidine;(R)-1-Cbz-piperidine-3-carboxylic acid - [P12343];(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
CBNumber
CB2433479
Molecular Formula
C14H17NO4
Formula Weight
263.29
MOL File
160706-62-7.mol
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(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Property

Boiling point:
443.9±45.0 °C(Predicted)
Density 
1.265
storage temp. 
2-8°C
pka
4.48±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B700285
Product name
(R)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylicAcid
Packaging
500mg
Price
$90
Updated
2021/12/16
Synthonix
Product number
P12343
Product name
(R)-1-Cbz-piperidine-3-carboxylicacid
Purity
95+%
Packaging
1g
Price
$40
Updated
2021/12/16
Matrix Scientific
Product number
074061
Product name
(R)-Piperidine-1,3-dicarboxylic acid1-benzyl ester
Purity
95+%
Packaging
1g
Price
$61
Updated
2021/12/16
AK Scientific
Product number
W3488
Product name
(R)-Piperidine-1,3-dicarboxylicacid1-benzylester
Packaging
1g
Price
$83
Updated
2021/12/16
Chem-Impex
Product number
17563
Product name
Z-D-nipecoticacid,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$28
Updated
2021/12/16
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(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Chemical Properties,Usage,Production

Synthesis

501-53-1

498-95-3

160706-62-7

GENERAL STEPS: (R)-Piperidine-3-carboxylic acid (XXVII) (5.0 g, 39 mmol) was dissolved in a solvent mixture of 50 mL of THF and 20 mL of water and cooled to 0 °C. Subsequently, sodium bicarbonate (6.5 g, 77.4 mmol) and benzyl chloroformate (8.0 g, 46.4 mmol) were added. The reaction mixture was stirred at 0 °C for 30 min and then continued to stir at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. The remaining aqueous phase was extracted with ether to remove unreacted benzyl chloroformate, then the pH was adjusted to 6 with 1 M HCl solution and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give 1-benzyl ester of (R)-piperidine-1,3-dicarboxylic acid (XXVIII) (3.7 g, 36% yield). Mass spectrum (MS): m/z = 263.9 (M + 1). 1H NMR (DMSO-d6) δ = 7.38 (5H, m), 5.12 (2H, s), 4.19-3.90 (2H, m), 3.02 (1H, m), 2.44 (1H, m), 2.05 (1H, m), 1.80-1.40 (3H, m).

References

[1] Patent: WO2009/47359, 2009, A1. Location in patent: Page/Page column 160
[2] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 771 - 783

(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Suppliers

China 74 Germany 2 India 2 Switzerland 2 United Kingdom 5 United States 18 Global 103
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View Lastest Price from (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER manufacturers

Career Henan Chemical Co
Product
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 160706-62-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

160706-62-7, (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTERRelated Search:

(S)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER (S)-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER,PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER Nipecotic acid 4-METHYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2S,3R-1-CBZ-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID Cbz-DL-3-Aminoisobutyric acid (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Cbz-R-3-Aminoisobutyric acid 2-METHYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 4-ISOPROPYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER

  • D-1-CBZ-NIPECOTIC ACID
  • (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
  • (R)-1-CBZ-PIPERIDINE-3-CARBOXYLIC ACID
  • (R)-1-[(BENZYLOXY)CARBONYL]PIPERIDINE-3-CARBOXYLIC ACID
  • (R)-1-Benzyloxycarbonylnipecotic acid
  • 3(R)-N-(Carbobenzyloxy)-3-carboxypiperidine
  • (R)-1-CBZ-PIPERIDINE-1-CARBOXYLIC ACID
  • 1-Cbz-(3R)-3-piperidinecarboxylic acid
  • 1,3-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester, (3R)-
  • (3R)-1-[(benzyloxy)carbonyl]piperidine-3-carboxylic acid
  • (R)-(+)-N-cbz-3-piperidinecarboxylic acid
  • (3R)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid
  • (R)-1-CBZ-3-piperidinecarboxylic acid
  • (R)-1-Cbz-piperidine-3-carboxylic acid - [P12343]
  • 160706-62-7