ChemicalBook > CAS DataBase List > Olprinone

Olprinone

Product Name
Olprinone
CAS No.
106730-54-5
Chemical Name
Olprinone
Synonyms
LOPRINONE;OLPRINONE;Olprinone [inn];Olprinone USP/EP/BP;Olprinone(Loprinone);3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester;1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile;1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-;1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
CBNumber
CB2438515
Molecular Formula
C14H10N4O
Formula Weight
250.26
MOL File
106730-54-5.mol
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Olprinone Property

Melting point:
>300°
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO
form 
Powder
pka
6.59±0.10(Predicted)
color 
White to off-white
CAS DataBase Reference
106730-54-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
3950AH
Product name
Olprinone
Packaging
100mg
Price
$157
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003677
Product name
OLPRINONE
Purity
95.00%
Packaging
10MG
Price
$263.55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003677
Product name
OLPRINONE
Purity
95.00%
Packaging
100MG
Price
$1030.84
Updated
2021/12/16
Ambeed
Product number
A168914
Product name
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Purity
98+%
Packaging
5mg
Price
$62
Updated
2021/12/16
Ambeed
Product number
A168914
Product name
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Purity
98+%
Packaging
10mg
Price
$80
Updated
2021/12/16
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Olprinone Chemical Properties,Usage,Production

Description

Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.

Uses

Olprinone is used in the treatment of acute myocardial insufficiency.

Definition

ChEBI: Olprinone is a member of bipyridines.

Side effects

1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.

Synthesis

4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.

Olprinone Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 2-Cyanoacetamide

Preparation Products

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View Lastest Price from Olprinone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Olprinone 106730-54-5
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09
Career Henan Chemical Co
Product
Olprinone 106730-54-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-01

106730-54-5, OlprinoneRelated Search:

Tribenuron methyl Azamethiphos Methyl salicylate METSULFURON METHYL 2-Chloro-5-chloromethylpyridine 4-Methylpyridine Thiophanate-methyl Methyl acetate 1-Methylimidazole 2,6-Lutidine Kresoxim-methyl Pirimiphos-methyl 2,4,6-Collidine Methyl Olprinone Hydrochloride 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Methyl bromide Parathion-methyl

  • 1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile
  • 5-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-yl)-6-methyl-2-oxo-1h-pyridine-3-carbonitrile
  • OLPRINONE
  • 5-(Imidazo[1,2-a]pyridine-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • Olprinone [inn]
  • 3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester
  • 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
  • 3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
  • LOPRINONE
  • Olprinone(Loprinone)
  • 1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile
  • Olprinone USP/EP/BP
  • 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • 106730-54-5
  • API