Olprinone

Product Name: Olprinone
CAS No.: 106730-54-5
Chemical Name: Olprinone
Synonyms: LOPRINONE;OLPRINONE;Olprinone [inn];Olprinone USP/EP/BP;Olprinone(Loprinone);3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester;1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile;1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-;1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
CBNumber: CB2438515
Molecular Formula: C14H10N4O
Formula Weight: 250.26
MOL File: 106730-54-5.mol

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Olprinone Property

Melting point:: >300°
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO
form: Powder
pka: 6.59±0.10(Predicted)
color: White to off-white
CAS DataBase Reference: 106730-54-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3950AH
Product name: Olprinone
Packaging: 100mg
Price: $157
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003677
Product name: OLPRINONE
Purity: 95.00%
Packaging: 10MG
Price: $263.55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003677
Product name: OLPRINONE
Purity: 95.00%
Packaging: 100MG
Price: $1030.84
Updated: 2021/12/16

Ambeed

Product number: A168914
Product name: 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Purity: 98+%
Packaging: 5mg
Price: $62
Updated: 2021/12/16

Ambeed

Product number: A168914
Product name: 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Purity: 98+%
Packaging: 10mg
Price: $80
Updated: 2021/12/16

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Olprinone Chemical Properties,Usage,Production

Description

Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.

Uses

Olprinone is used in the treatment of acute myocardial insufficiency.

Definition

ChEBI: Olprinone is a member of bipyridines.

Side effects

1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.

Synthesis

4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.

Olprinone Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 2-Cyanoacetamide

Preparation Products

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Olprinone Suppliers

China 111 Europe 2 Germany 1 India 1 The Netherlands 1 United Kingdom 3 United States 13 Global 132

Jinan Sanyuan Chemical Co. LTD

Tel: 13335164090
Fax: 0531-58585914
Email: 1660423085@qq.com
Country: China
ProdList: 411
Advantage: 58

Shandong Fuchuang Pharmaceutical Technology Co. , Ltd.

Tel: 0531-88792816 18615587029
Email: fcpharm2006@126.com
Country: China
ProdList: 136
Advantage: 58

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd

Tel: 18901358086
Fax: 86-010-61252196
Email: pharma_reese@126.com
Country: China
ProdList: 56
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3203
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

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View Lastest Price from Olprinone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Olprinone 106730-54-5
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

Career Henan Chemical Co

Product: Olprinone 106730-54-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

106730-54-5, OlprinoneRelated Search:

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1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile

5-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-yl)-6-methyl-2-oxo-1h-pyridine-3-carbonitrile

OLPRINONE

5-(Imidazo[1,2-a]pyridine-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Olprinone [inn]

3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile

3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-

LOPRINONE

Olprinone(Loprinone)

1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile

Olprinone USP/EP/BP

5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

106730-54-5

API