ChemicalBook > CAS DataBase List > 4'-CHLORO-3-METHOXYCINNAMANILIDE

4'-CHLORO-3-METHOXYCINNAMANILIDE

Product Name
4'-CHLORO-3-METHOXYCINNAMANILIDE
CAS No.
472981-92-3
Chemical Name
4'-CHLORO-3-METHOXYCINNAMANILIDE
Synonyms
SB 366791;SB366791, >98%;SB 366791;SB366791;SB-366791, 10 mM in DMSO;SB-366791, TRPV1 antagonist;4'-CHLORO-3-METHOXYCINNAMANILIDE;N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE;4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791);3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide;(E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE
CBNumber
CB2449409
Molecular Formula
C16H14ClNO2
Formula Weight
287.74
MOL File
472981-92-3.mol
More
Less

4'-CHLORO-3-METHOXYCINNAMANILIDE Property

Melting point:
165-167℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 13 mg/mL, soluble
form 
solid
color 
off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2924.29.7790
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S0441
Product name
SB-366791
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$212
Updated
2025/07/31
Sigma-Aldrich
Product number
S0441
Product name
SB-366791
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$837
Updated
2025/07/31
TCI Chemical
Product number
B5762
Product name
SB-366791
Packaging
25MG
Price
$132
Updated
2025/07/31
TCI Chemical
Product number
B5762
Product name
SB-366791
Packaging
100MG
Price
$362
Updated
2025/07/31
Cayman Chemical
Product number
11019
Product name
SB-366791
Purity
≥98%
Packaging
5mg
Price
$60
Updated
2024/03/01
More
Less

4'-CHLORO-3-METHOXYCINNAMANILIDE Chemical Properties,Usage,Production

Description

SB-366791 (472981-92-3) is a potent (IC50 = 0.7 μM) and selective TRPV1 blocker.1,2 Selective for TRPV1 in a panel of 47 different binding assays.

Uses

N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1.

Uses

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:

  • to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
  • to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
  • to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)

Definition

ChEBI: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.

Biological Activity

Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .

Biochem/physiol Actions

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.

storage

Store at RT

References

[1] M.J. GUNTHORPE . Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist[J]. Neuropharmacology, 2004, 46 1: Pages 133-149. DOI:10.1016/s0028-3908(03)00305-8
[2] ANGELIKA VARGA . Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat[J]. Neuroscience Letters, 2005, 385 2: Pages 137-142. DOI:10.1016/j.neulet.2005.05.015

4'-CHLORO-3-METHOXYCINNAMANILIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4'-CHLORO-3-METHOXYCINNAMANILIDE Suppliers

Americas 1 China 109 Europe 1 Germany 1 India 3 Japan 1 Switzerland 3 United Kingdom 3 United States 15 Global 137
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29759
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
Advantage
55
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
836
Advantage
55
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9750
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
021-58958618
Email
sales@uhnshanghai.com
Country
China
ProdList
1984
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3277
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1991
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Amel Pharmatech Corporation
Tel
027-888-4366503
Fax
888-502-1736
Email
sales@amelpharmatech.com
Country
China
ProdList
5000
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
Jingmo (Xiamen) Biotechnology Co., Ltd
Tel
13621943973; 13621943973
Email
sales@jamxmpharmatech.com
Country
China
ProdList
1168
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9778
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel
+86-021-61551413 +8618813727289
Email
contact@trustwe.com
Country
China
ProdList
5743
Advantage
58
Cangzhou Pintuo Biotechnology Co., Ltd.
Tel
15231732623
Email
1979763395@qq.com
Country
China
ProdList
187
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4494
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4810
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
Advantage
58
Nantong Feiyu Biological Technology CO.,LTD
Tel
0513-68819626; 15152877458
Fax
0513-68669626
Email
feiyubio@163.com
Country
China
ProdList
4817
Advantage
58
More
Less

View Lastest Price from 4'-CHLORO-3-METHOXYCINNAMANILIDE manufacturers

Career Henan Chemica Co
Product
4'-CHLORO-3-METHOXYCINNAMANILIDE 472981-92-3
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-10-28

472981-92-3, 4'-CHLORO-3-METHOXYCINNAMANILIDERelated Search:

5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE SB1317 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline SB-705498 SB 203580 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Ispinesib SB 431542 SB 202190 SB 415286 SB 242084 (hydrochloride) MMP-2/MMP-9 INHIBITOR IV Sb-742457 SB216763 SB 225002 Pracinostat

  • N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE
  • SB 366791
  • 4'-CHLORO-3-METHOXYCINNAMANILIDE
  • 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
  • (E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE
  • 2-Propenamide,3-(4-chlorophenyl)-N-(3-methoxyphenyl)-
  • SB 366791;SB366791
  • SB366791, >98%
  • 4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791)
  • 3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide
  • SB-366791, TRPV1 antagonist
  • SB-366791, 10 mM in DMSO
  • 472981-92-3
  • C16H14NO2Cl
  • Vanilloid/TRPV channel
  • API