ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE
- Product Name
- ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE
- CAS No.
- 100491-29-0
- Chemical Name
- ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE
- Synonyms
- ETHYL 1-(2;RRR-α-Tocopherolum;Tosufloxacin Impurity;Tosufloxacin Impurity 2;3-B] PYRIDINE-3-CARBOXYLATE;Ethyl 7-chloro-1-(2,4-difluorophenyl);4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2;-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate;ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYR...;ethyl1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxohydropyridino
- CBNumber
- CB2461449
- Molecular Formula
- C17H10ClF3N2O3
- Formula Weight
- 382.72
- MOL File
- 100491-29-0.mol
ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE Property
- Melting point:
- 212-215 °C
- Boiling point:
- 502.5±50.0 °C(Predicted)
- Density
- 1.4752 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
- form
- Solid
- pka
- -3.23±0.70(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E1180
- Product name
- Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- E1180
- Product name
- Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- C366350
- Product name
- 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicAcidEthylEster
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C366350
- Product name
- 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicAcidEthylEster
- Packaging
- 10g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- C366350
- Product name
- 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicAcidEthylEster
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
almost white powder
Uses
An intermediate of Trovafloxacin (T893000) and analogs.
Synthesis
105152-47-4
100491-29-0
(1) 250 mg of phosphoryl chloride was slowly added dropwise to 4 mL of N,N-dimethylformamide followed by 200 mg of 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-methoxynicotinoyl]ethyl acetate under cooling conditions in an ice bath and stirred for 10 min keeping the same temperature. Next, ethyl acetate was added to the reaction mixture. The reaction system was warmed up to 50-60°C for 3.5 hours. Upon completion of the reaction, the mixture was poured into 50 mL of ice water and extracted by adding 20 mL of chloroform, the organic layer was separated, washed with 20 mL of water and subsequently dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure, 5 mL of ether was added to the residue, and the crystals were collected by filtration to afford 150 mg (72.2% yield) of ethyl 7-chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-diazanaphthalene-3-carboxylate, melting point 217-220 °C. The solvent was concentrated under reduced pressure. Crystals with melting points of 219-221°C were obtained by recrystallization from acetone-methanol solvent mixture (1:1, v/v). Elemental analysis (C17H10N2O3ClF3) Calculated values (%): C, 53.35; H, 2.63; N, 7.32. Measured values (%): C, 53.61; H, 2.47; N, 6.96.
References
[1] Patent: US4704459, 1987, A
ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE Suppliers
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- 03-36680489
- Fax
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- Country
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View Lastest Price from ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE manufacturers
- Product
- ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE 100491-29-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- As your request
- Release date
- 2025-11-03
- Product
- Tosufloxacin Impurity 100491-29-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 100000
- Release date
- 2025-03-12
- Product
- ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE 100491-29-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13