2-Chloro-3-fluoro-5-methylpyridine
- Product Name
- 2-Chloro-3-fluoro-5-methylpyridine
- CAS No.
- 34552-15-3
- Chemical Name
- 2-Chloro-3-fluoro-5-methylpyridine
- Synonyms
- 6-Chloro-5-fluoro-3-picoline;2-CHLORO-3-FLUORO-5-PICOLINE;2-CHLORO-3-FLUORO-5-METHYLPYRIDINE;Pyridine, 2-chloro-3-fluoro-5-methyl-;2-Chloro-3-fluoro-5-methylpyridine,95%;2-Chloro-3-fluoro-5-methylpyridine ISO 9001：2015 REACH;2-Chloro-3-fluoro-5-picoline 2-Chloro-3-fluoro-5-methylpyridine
- CBNumber
- CB9666188
- Molecular Formula
- C6H5ClFN
- Formula Weight
- 145.56
- MOL File
- 34552-15-3.mol
2-Chloro-3-fluoro-5-methylpyridine Property
- Melting point:
- 29-30 °C
- Boiling point:
- 92°C/25mmHg(lit.)
- Density
- 1.264±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- pka
- 0.35±0.10(Predicted)
- form
- Solid
- color
- White
- CAS DataBase Reference
- 34552-15-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3275
- Product name
- 2-Chloro-3-fluoro-5-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- C3275
- Product name
- 2-Chloro-3-fluoro-5-methylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $160
- Updated
- 2025/07/31
- Product number
- C585028
- Product name
- 2-Chloro-3-fluoro-5-methylpyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C585028
- Product name
- 2-Chloro-3-fluoro-5-methylpyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 024736
- Product name
- 2-Chloro-3-fluoro-5-methylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
2-Chloro-3-fluoro-5-methylpyridine Chemical Properties,Usage,Production
Synthesis
99268-30-1
34552-15-3
Example 11 Preparation of 2-chloro-3-fluoro-5-methylpyridine: 1.92 g of 2-fluoro-4-chloro-4-formylpentanenitrile (CAS: 99268-30-1) was placed in a 50 mL Carius tube and 10 mL of acetonitrile was added as a solvent. Dry HCl gas was passed into the reaction system for 10 seconds. Subsequently, the reaction mixture was heated at 180°C for 20 min. After completion of the reaction, the acetonitrile solvent was evaporated under reduced pressure. The residue was dissolved in 5 mL of dichloromethane and purified by silica gel column chromatography (230-400 mesh, 4 cm × 20 cm). The first fraction containing the target product 2-chloro-3-fluoro-5-methylpyridine was collected. The solvent was removed under vacuum to give 700 mg of product in 44% yield. The product was characterized by the following data: 1H NMR (acetone-d6) δ 2.35 (s, 3H, -CH3), 7.50 (dd, 1H, pyr-H4), 8.07 (wide s, 1H, pyr-H6); IR (NaCl, neat) 1450 cm-1, 1408 cm-1, 1215 cm-1, 1085 cm-1, 880 cm -1, 720 cm-1, 711 cm-1; CIMS (CM4) MH+ m/e 146 (100%), MH++2 m/e 148 (35%).
References
[1] Journal of Organic Chemistry, 1985, vol. 50, # 25, p. 5115 - 5119
[2] Patent: US4562009, 1985, A
2-Chloro-3-fluoro-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-fluoro-5-methylpyridine manufacturers
- Product
- 2-Chloro-3-fluoro-5-methylpyridine 34552-15-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Chloro-3-fluoro-5-methylpyridine 34552-15-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Chloro-3-fluoro-5-methylpyridine 34552-15-3
- Price
- US $10.00/KG
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-14