Description References
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Thiamine nitrate

Description References
Product Name
Thiamine nitrate
CAS No.
532-43-4
Chemical Name
Thiamine nitrate
Synonyms
THIAMINE MONONITRATE;Vitamin B1 Mono;Thiamin Mononitrate;ThiaMine Monohydrate;VITAMIN B1 NITRATE;vitamin Bl mononitrate;VITAMIN B1 MONONITRATE;D03277;Vitanon;mnitrate
CBNumber
CB2472353
Molecular Formula
C12H17N5O4S
Formula Weight
327.36
MOL File
532-43-4.mol
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Thiamine nitrate Property

Melting point:
374-392 °C
storage temp. 
2-8°C
solubility 
Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol.
form 
solid
pka
4.8(at 25℃)
color 
White to Off-White
Odor
wh. cryst. or cryst. powd., sl. char. odor
Merck 
14,9295
BRN 
3857790
Stability:
Stable. Incompatible with strong oxidizing agents.
InChI
InChI=1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1
InChIKey
UIERGBJEBXXIGO-UHFFFAOYSA-N
SMILES
[N+]1(CC2=CN=C(C)N=C2N)C(C)=C(SC=1)CCO.[N+]([O-])([O-])=O
CAS DataBase Reference
532-43-4(CAS DataBase Reference)
EPA Substance Registry System
Thiamine nitrate (532-43-4)
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Safety

Safety Statements 
22-24/25
WGK Germany 
1
RTECS 
XI7400000
TSCA 
Yes
HS Code 
29362200
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1337
Product name
Thiamine Nitrate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$94.3
Updated
2024/03/01
Sigma-Aldrich
Product number
BP414
Product name
Thiamine mononitrate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$269
Updated
2024/03/01
TCI Chemical
Product number
T0182
Product name
Thiamine Nitrate
Purity
>98.0%(HPLC)(E)
Packaging
25g
Price
$83
Updated
2024/03/01
TCI Chemical
Product number
T0182
Product name
Thiamine Nitrate
Purity
>98.0%(HPLC)(E)
Packaging
100g
Price
$173
Updated
2024/03/01
Alfa Aesar
Product number
J60014
Product name
Thiamine nitrate
Packaging
10g
Price
$44.1
Updated
2024/03/01
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Thiamine nitrate Chemical Properties,Usage,Production

Description

Thiamine nitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. It occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations.
Thiamine nitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour.

References

[1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995
[2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008
[3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369

Description

Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).

Chemical Properties

White or almost white, crystalline powder or small, colourless crystals.

Uses

Thiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function.

Uses

Vitamin B1.

benefits

Some of the critical uses and benefits of Vitamin B1 Mononitrate(Thiamine nitrate) include:
Supports Energy production: Thiamine nitrate is involved in converting food into energy, particularly in the metabolism of carbohydrates.
Helps Nervous system: Thiamine nitrate is essential for proper nervous system function and is involved in transmitting nerve impulses.
Improves Cardiovascular health: Thiamine nitrate is important for maintaining healthy heart function, and may help to reduce the risk of heart disease.
Supports Appetite regulation: Vitamin B1 mononitrate is involved in regulating appetite and may help to reduce the risk of overeating and weight gain.
Improves Eye health: Thiamine nitrate is involved in maintaining healthy eye function, and may help to reduce the risk of certain eye disorders.

General Description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour.

Safety Profile

Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES.

Thiamine nitrate Preparation Products And Raw materials

Raw materials

Acetamidine hydrochloride Ammonium hydroxide (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Quinoline Pyramat 3-Methoxypropionitrile N-ACETYL-D-GALACTOSAMINE(GALACTOSE-13C6, 99%) Thiamine hydrochloride

Preparation Products

Thiamine hydrochloride
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View Lastest Price from Thiamine nitrate manufacturers

Sinoway Industrial co., ltd.
Product
vitamin B1 mono 532-43-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-08-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Thiamine nitrate 532-43-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%-101%; BP/USP
Supply Ability
1000KGS
Release date
2024-07-22
Hebei Yanxi Chemical Co., Ltd.
Product
Thiamine nitrate 532-43-4
Price
US $50.00-7.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-14

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