Proglumide

ChemicalBook > CAS DataBase List > Proglumide

Product Name: Proglumide
CAS No.: 6620-60-6
Chemical Name: Proglumide
Synonyms: ProM;kxm;xyde;242dl;cr242;milid;nulsa;w5219;milide;Promid
CBNumber: CB2479493
Molecular Formula: C18H26N2O4
Formula Weight: 334.41
MOL File: 6620-60-6.mol

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Proglumide Property

Melting point:: 148-150°C
Boiling point:: 471.21°C (rough estimate)
Density: 1.1944 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.51±0.10(Predicted)
color: Crystals
CAS DataBase Reference: 6620-60-6(CAS DataBase Reference)
EPA Substance Registry System: Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)

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Safety

Toxicity: LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P755955
Product name: Proglumide
Packaging: 2g
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-8029
Product name: Proglumide
Purity: 99.74%
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP166197
Product name: Proglumide
Packaging: 100mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: H786
Product name: Proglumide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-8029
Product name: Proglumide
Purity: 99.74%
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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Proglumide Chemical Properties,Usage,Production

Description

Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.

Chemical Properties

White Solid

Uses

Anticholinergic.

Definition

ChEBI: Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as a drug metabolite, a xenobiotic metabolite, a cholinergic antagonist, an anti-ulcer drug, a cholecystokinin antagonist, a gastrointestinal drug, a delta-opioid receptor agonist and an opioid analgesic. It contains a (R)-proglumide and a (S)-proglumide.

brand name

Nulsa (Wallace).

Side effects

An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.
Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.

Safety Profile

Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.

Proglumide Preparation Products And Raw materials

Raw materials

Dipropylamine Benzoyl chloride

Preparation Products

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View Lastest Price from Proglumide manufacturers

Sinoway Industrial co., ltd.

Product: Proglumide 6620-60-6
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-05-11

Shanghai Aosiris new Material Technology Co., LTD

Product: Proglumide 6620-60-6
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-04-16

Liaoning Pharmaceutical Innovation Co., Ltd

Product: Proglumide 6620-60-6
Price: US $150.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-03-06

6620-60-6, ProglumideRelated Search:

Carbenoxolone Cimetidine Atropine Cisapride PROGLUMETACIN MALEATE Proglumide DEXLOXIGLUMIDE LOXIGLUMIDE LORGLUMIDE AMIGLUMIDE PROGLUMIDE SODIUM SALT SELECTIVE CHOLECY STOK,PROGLUMIDE SODIUM,PROGLUMIDE, SODIUM SALT Proglumide CP2000 Tomoglumide (+-)-4-((3,4-Difluorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5 -oxopentanoic acid 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(2 -((4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl)oxy)ethoxy)-2-ox oethyl ester, (+-)- L-Proglumide D-Proglumide (+-)-4-((3,4-Dimethylbenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5 -oxopentanoic acid

PROGLUMIDE

(+/-)-4-benzamido-n,n-dipropylglutaramic acid

LABOTEST-BB LT00772215

N(2)-benzoyl-N,N-dipropyl-alpha-glutamine

4-(BenzoylaMino)-5-(dipropylaMino)-5-oxo-pentanoic Acid

ProM

4-BenzaMido-5-(dipropylaMino)-5-oxopentanoic acid

N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine

(+-)-pentanoicaci

242dl

binoside

cr242

dl-4-benzamido-n,n-dipropylglutaramicacid

gastrotopic

kxm

midelid

milid

milide

n-dipropyl-4-benzamido-dl-glutaramicaci

nulsa

promide(parasympatholytic)

ulcutin

w5219

xyde

xylamide

xylamide(gastroprotectiveagent)

4-benzamido-N,N-dipropyl-DL-glutaramic acid

PROGLUMIDE SELECTIVE CHOLECYSTOK

DL-Proglumide

Glutaramic acid, 4-benzamido-N,N-dipropyl-, DL- (8CI)

Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (9CI)

Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)-

PROGUMIDE

Promid

Xylamide(gastroprotectite agent)

D01818

Nulsa (tn)

Proglumide (jp15/usan/inn)

(4R)-4-benzamido-5-(dipropylamino)-5-oxopentanoic acid

Proglumide USP/EP/BP

99% Proglumide

Factory Supply Bulk Price 99% Proglumide CAS?6620-60-6?with High Quality in Stock

proglumide(6620-60-6)

NSC 9416

NSC9416

NSC-9416

Diethylaminosulfur trifluoride 38078-09-0

6620-60-6

620-60-6

NULSA

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals