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Proglumide

Product Name
Proglumide
CAS No.
6620-60-6
Chemical Name
Proglumide
Synonyms
ProM;kxm;xyde;242dl;cr242;milid;nulsa;w5219;milide;Promid
CBNumber
CB2479493
Molecular Formula
C18H26N2O4
Formula Weight
334.41
MOL File
6620-60-6.mol
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Proglumide Property

Melting point:
148-150°C
Boiling point:
471.21°C (rough estimate)
Density 
1.1944 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.51±0.10(Predicted)
color 
Crystals
CAS DataBase Reference
6620-60-6(CAS DataBase Reference)
EPA Substance Registry System
Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)
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Safety

Toxicity
LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P755955
Product name
Proglumide
Packaging
2g
Price
$155
Updated
2021/12/16
ChemScene
Product number
CS-8029
Product name
Proglumide
Purity
99.74%
Packaging
100mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
BP166197
Product name
Proglumide
Packaging
100mg
Price
$50
Updated
2021/12/16
AK Scientific
Product number
H786
Product name
Proglumide
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-8029
Product name
Proglumide
Purity
99.74%
Packaging
50mg
Price
$60
Updated
2021/12/16
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Proglumide Chemical Properties,Usage,Production

Description

Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.

Chemical Properties

White Solid

Uses

Anticholinergic.

Definition

ChEBI: Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as a drug metabolite, a xenobiotic metabolite, a cholinergic antagonist, an anti-ulcer drug, a cholecystokinin antagonist, a gastrointestinal drug, a delta-opioid receptor agonist and an opioid analgesic. It contains a (R)-proglumide and a (S)-proglumide.

brand name

Nulsa (Wallace).

Side effects

An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.
Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.

Safety Profile

Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.

Proglumide Preparation Products And Raw materials

Raw materials

Preparation Products

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Proglumide Suppliers

Changzhou Yabang Pharmaceutical Co., LTD.
Tel
0519-86388158
Fax
0086-519-86388160
Email
xujian@yabangpharma.com
Country
China
ProdList
80
Advantage
51
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
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View Lastest Price from Proglumide manufacturers

Sinoway Industrial co., ltd.
Product
Proglumide 6620-60-6
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
0.99
Supply Ability
20 tons
Release date
2023-05-11
Baoji Guokang Bio-Technology Co., Ltd.
Product
Proglumide 6620-60-6
Price
US $121.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000T
Release date
2021-06-04
Hebei Weibang Biotechnology Co., Ltd
Product
Proglumide 6620-60-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-09-30

6620-60-6, ProglumideRelated Search:


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  • 99% Proglumide
  • Factory Supply Bulk Price 99% Proglumide CAS?6620-60-6?with High Quality in Stock
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