2,6-Dichlorophenylacetic acid

ChemicalBook > CAS DataBase List > 2,6-Dichlorophenylacetic acid

2,6-Dichlorophenylacetic acid

Product Name: 2,6-Dichlorophenylacetic acid
CAS No.: 6575-24-2
Chemical Name: 2,6-Dichlorophenylacetic acid
Synonyms: 2-(2,6-DICHLOROPHENYL)ACETIC ACID;TIMTEC-BB SBB003503;RARECHEM AL BO 0115;2,6-Dichlorophenyla;Guanfacine Impurity;Guanfacine Impurity 1;2,6-Dichlorphenylessigsure;6-Dichlorophenylacetic acid;2,6-DICHLOROPHENYLACETIC ACID;2,6-DICHLORO BENZENEACETIC ACID
CBNumber: CB2481995
Molecular Formula: C8H6Cl2O2
Formula Weight: 205.04
MOL File: 6575-24-2.mol

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2,6-Dichlorophenylacetic acid Property

Melting point:: 158-161 °C (lit.)
Boiling point:: 294.45°C (rough estimate)
Density: 1.3806 (rough estimate)
refractive index: 1.5490 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.80±0.10(Predicted)
color: White to Off-White
BRN: 1952744
InChI: InChI=1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12)
InChIKey: SFAILOOQFZNOAU-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=C(Cl)C=CC=C1Cl
CAS DataBase Reference: 6575-24-2(CAS DataBase Reference)
NIST Chemistry Reference: 2,6-Dichlorophenylacetic acid(6575-24-2)
EPA Substance Registry System: Benzeneacetic acid, 2,6-dichloro- (6575-24-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-26/37/39-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29163900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 259241
Product name: 2,6-Dichlorophenylacetic acid
Purity: 97%
Packaging: 25g
Price: $39.2
Updated: 2023/06/20

Sigma-Aldrich

Product number: 259241
Product name: 2,6-Dichlorophenylacetic acid
Purity: 97%
Packaging: 100g
Price: $149
Updated: 2023/06/20

TCI Chemical

Product number: D1897
Product name: 2,6-Dichlorophenylacetic Acid
Purity: >96.0%(T)
Packaging: 25g
Price: $133
Updated: 2024/03/01

Alfa Aesar

Product number: B21354
Product name: 2,6-Dichlorophenylacetic acid, 98%
Packaging: 5g
Price: $22.65
Updated: 2024/03/01

Alfa Aesar

Product number: B21354
Product name: 2,6-Dichlorophenylacetic acid, 98%
Packaging: 25g
Price: $59.65
Updated: 2024/03/01

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2,6-Dichlorophenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells.

Preparation

The preparation of the 2, 6-dichlorophenylacetic acid:
the method comprises the following steps: 2, 6-dichlorotoluene is used as a raw material, and is catalyzed by a complex catalyst formed by transition metal and a ligand (wherein, a transition metal catalyst precursor is preferably palladium chloride, an oxidant is preferably TBP (tert-butyl peroxy ether), and a ligand is preferably Xantphos (4, 5-bis (diphenylphosphino) -9, 9-dimethyl xanthene)) in the presence of an alcohol and a catalyst and an oxidant to obtain 2, 6-dichlorophenylacetic acid, and the ethyl 2, 6-dichlorophenylacetate is prepared by hydrolysis and acidification, wherein the total yield is 68.4%. See patent document US2013303798, the reaction procedure is described as synthetic route 1.

In the above synthetic route 1, the preparation process of the intermediate ethyl 2, 6-dichlorophenylacetate requires the use of carbon monoxide for high-temperature and high-pressure reaction, and has poor operation safety, high equipment requirement, high cost, and is not favorable for cost reduction and green production of 2, 6-dichlorophenylacetic acid.

Purification Methods

Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]

2,6-Dichlorophenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-Dichlorophenylacetic acid manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2,6-Dichlorophenylacetic acid 6575-24-2
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-15

Wuhan Boye Science And Technology Development Co., Ltd.

Product: 2,6-Dichlorophenylacetic acid 6575-24-2
Price: US $614.40/Kg/Drum
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10tons
Release date: 2021-03-23

Hebei Guanlang Biotechnology Co., Ltd.

Product: 2,6-Dichlorophenylacetic acid 6575-24-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-10-25

6575-24-2, 2,6-Dichlorophenylacetic acidRelated Search:

4-Methoxyphenylacetic acid 4-Hydroxyphenylacetic acid 2-Hydroxyphenylacetic acid 2,6-DICHLOROPHENYLACETIC ACID METHYL ESTER 2,6-DICHLOROPHENYLACETAMIDE Benzeneacetamide, N-(aminoiminomethyl)-2-chloro- GUANFACINE HCL Guanidine hydrochloride 2,6-Dichlorophenylacetic acid nitrile 2,4-DICHLOROPHENYLACETIC ACID METHYL ESTER,2,4-DICHLOROPHENYLACETIC ACID METHYL ESTER STANDARD Phenylacetic acid 2,4-Dichlorophenylacetic acid 3,4-DICHLOROPHENYLACETIC ACID,3,4-Dichlorophenylacetic acid ,99% Testosterone phenylacetate 2,3-DICHLOROPHENYLACETIC ACID,2,3-DICHLOROPHENYLACETIC ACID 99% METHYL 2,3-DICHLOROPHENYLACETATE 3,4-DICHLOROPHENYLACETIC ACID METHYL ESTER CHLOROBENZILATE

2-(2,6-DICHLOROPHENYL)ACETIC ACID

2,6-DICHLORO BENZENEACETIC ACID

2,6-DICHLOROPHENYLACETIC ACID

RARECHEM AL BO 0115

TIMTEC-BB SBB003503

2,6-Dichlorphenylessigsure

Guanfacine Impurity 1

Benzeneacetic acid, 2,6-dichloro-

2,6-Dichlorophenyl acetic acid 98%

2,6-Dichlorophenylacetic acid, 98+%

Acetic acid, (2,6-dichlorophenyl)-

2,6-Dichlorophenylacetic acid,99%

6-Dichlorophenylacetic acid

2,6-two chlorophenyl acetic acid

2,6-Dichlorophenyla

2,6-DichlorophenylaceticAcid&gt

Guanfacine Carboxylic Acid Impurity

Guanfacine hydrochloride impurity B(2,6-Dichlorophenylacetic acid)

Guanfacine Hydrochloride Impurity 3

Guanfacine Impurity

6575-24-2

C8H6Cl2O2

C8H6O2Cl2

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Carbonyl Compounds

Carboxylic Acids

Aromatic Phenylacetic Acids and Derivatives

Phenylacetic acid

Acids and Derivatives